Ask about this productRelated genes to: ICAM2 antibody
- Gene:
- ICAM2 NIH gene
- Name:
- intercellular adhesion molecule 2
- Previous symbol:
- -
- Synonyms:
- CD102
- Chromosome:
- 17q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-06
- Date modifiied:
- 2015-08-28
Related products to: ICAM2 antibody
Related articles to: ICAM2 antibody
- Simian immunodeficiency viruses (SIVs) have crossed from apes to humans at least four times, but only one event gave rise to the AIDS pandemic. The host barriers that pandemic HIV-1 group M () strains overcame to spread efficiently in humans remain poorly understood. To identify such barriers, we performed CRISPR-Cas9 screens driven by the replication efficiency of SIVcpz, the chimpanzee precursor of HIV-1. Guide RNA libraries targeting more than 500 human genes encoding potential antiviral factors were inserted into the replication-competent SIVcpz MB897 molecular clone, which is phylogenetically closely related to HIV-1 group M strains. Propagation in Cas9-expressing human SupT1 T cells significantly enriched for sgRNAs targeting and . These hits only partially overlapped with those identified in analogous HIV-1-based screens, indicating virus-specific restriction profiles. Functional analyses confirmed that IFITM2 (interferon-induced transmembrane protein 2), PCED1B (PC-esterase domain-containing protein 1B), MEFV (Mediterranean fever protein, pyrin/TRIM20), and AXIN1 (Axis inhibition protein 1) restrict replication of the analyzed SIVcpz strains but not HIV-1 group M strains in primary human CD4 T cells. These findings reveal previously unrecognized host factors that limit SIVcpz replication in human cells and highlight barriers that at least some HIV-1 group M strains overcame during adaptation for pandemic spread. - Source: PubMed
Publication date: 2026/05/07
Xie QinyaWang QingxingNoettger SabrinaGosálbez GuillermoBetzler Annika CVolcic MetaKmiec DorotaKrebs StefanGraf AlexanderGülensoy DilaWeidinger GilbertSparrer Konstantin M JKirchhoff Frank - As a representative next-generation probiotic, () produces a variety of functional proteins that play critical roles in the prevention and treatment of multiple diseases, including metabolic disorders, inflammatory diseases, neurological disorders, and cancer. This review summarizes the disease-associated proteins of reported to date, including the outer membrane proteins Amuc_1100 and Amuc_1098, as well as the secreted proteins P9 (Amuc_1631), P5, Amuc_1409, Amuc_1434, and Amuc_2109. These proteins exert their biological effects by activating multiple signaling pathways, such as Toll-like receptor 2 (TLR2), ICAM-2, and Wnt/β-catenin, thereby regulating physiological processes including glucagon-like peptide-1 (GLP-1) secretion, serotonin biosynthesis, lipid metabolism, and intestinal stem cell proliferation. This review provides a theoretical foundation and future perspectives for in-depth research investigation and clinical application of disease-related proteins. - Source: PubMed
Publication date: 2026/04/02
Han YanpingLu JuaneBu XueyingHu LiyingNiu ChangchengQiao JianjunWu HaoCaiyin Qinggele - Tumor-associated macrophages are key players in cancer progression, but their heterogeneity is not fully understood. This study aims to investigate the role of a specific macrophage subpopulation marked by LY6E in esophageal squamous cell carcinoma (ESCC). - Source: PubMed
Publication date: 2026/04/29
Chen KunNi JianjiaoLi YidaGu SijiaLi YeYang XiGoswami ShyamalLuo QiyuZhang YaleiQian LingHu YudiZhou RunyeWang YatingLiu JingjingCai XiuyuZhang ChunrongAfridi SaifullahChen YiWang PengZhu Zhengfei - We examined gene expression profiles in abdominal aortic aneurysm (AAA) lesions . normal aortas by cDNA microarray and real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). - Source: PubMed
Lu SongLi Li PingWhite John VZhang XiaoyingNwaneshiudu IfeyinwaNwaneshiudu AdaobiNtaoula NectariaGaughan JohnMonos Dimitri SLin Wan-LuSolomides Charalambos COleszak Emilia LPlatsoucas Chris D - Meningococcal Serogroup A conjugate vaccine, as compared to the polysaccharide vaccine, has been clinically proven to induce superior protective immune responses against serogroup A infection in infants and young children. Studies examining the immune pathways/biomarkers responsible for the superiority of conjugate over plain polysaccharide vaccines are greatly required. This study reports the comparative whole blood transcriptomic profiles of the late-stage immune responses induced by meningococcal polysaccharide and conjugate vaccine in a murine model. Unique peripheral gene transcripts were induced by the Men A PS-tetanus toxoid (Men A PS-TT) vaccine compared to the Men A PS-alum (Men A PS-ALPO4) vaccine. Conjugate vaccine reported significant expression for Actb, Cd1d1, Klra8, Klrd1, Tnf, and H2-Q10 genes. Whereas plain polysaccharide vaccine reported key changes for Itga2b, H2-Ab-1, Cd8b1, and Icam2 genes. Annotation studies reported markers related to cytokine and chemokine activation, T and B cell activation, NKT-cell mediated cytotoxicity, antigen processing and presentation, and complement activation were differentially expressed in the conjugate vaccine as compared to the polysaccharide vaccine. The study reports late-stage immune markers that could be potential biomarkers for a better understanding of pathways responsible for immunity to T cell-dependent and independent antigens. - Source: PubMed
Publication date: 2026/04/04
Patel KrunalGautam ManishGairola Sunil