Ask about this productRelated genes to: CD95 antibody
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 antibody
Related articles to: CD95 antibody
- Analysis of runs of homozygosity (ROH) in commercial breed genomes is important for accurately assessing the population inbreeding status and exploring homozygous regions related to economic traits formed by selection pressure. The Danish Large White (LW) pig is a commercially important breed renowned for its superior growth efficiency and reproductive performance. In the present study, we identified ROH segments of Danish LW pigs based on 43 individual whole-genome resequencing data. We then calculated the inbreeding coefficient and screened candidate genes with important economic traits from the ROH islands. A total of 9446 ROH segments were identified in the LW pig population. Each LW pig carried 219.67 ROH. Most ROH were , and the average genomic inbreeding coefficient ( ) in LW pigs was 0.24. However, the proportion of ROH ( ) in LW pigs has reached 10 %, indicating selection pressure or inbreeding in recent times. Candidate genes related to reproductive traits (, , , , , , and ), and growth and development traits (, , , , , , , , , , and ) were identified in the genomic ROH islands of LW pigs. In conclusion, the present study provides further assessment of genetic diversity and inbreeding in the Danish LW pig population. In addition, our results provide useful insights into the functions of ROH on a hereditary basis and the role that ROH play in controlling the excellent characteristics of Danish LW pigs. - Source: PubMed
Publication date: 2026/01/12
Ding WeiminWu XudongBu YuZhang WeiWang YuanlangDing YueyunZheng XianruiZhang XiaodongYin Zongjun - Fatty acids (FAs) are essential for cellular growth and homeostasis; however, their excessive accumulation induces lipotoxicity. To prevent FA-induced damage, eukaryotic cells sequester surplus FAs within cytosolic lipid droplets (LDs), dynamic organelles central to lipid storage, metabolism, and signaling. Emerging evidence indicates that LDs suppress ferroptosis, an iron-dependent programmed cell death, by channeling polyunsaturated fatty acids (PUFAs) away from membrane phospholipids, thereby limiting lipid peroxidation. Nonetheless, the molecular mechanisms linking LD biogenesis to ferroptosis susceptibility remain poorly defined. In a recent study published in The FEBS Journal, Kump et al., provided mechanistic insights into how triacylglycerol (TGs) biosynthesis and LD assembly regulate ferroptosis in cancer cells as a function of PUFA availability. Here, we discuss and contextualize their principal findings. - Source: PubMed
Publication date: 2026/04/24
Hanano AbdulsamieYousfan Amal - Ovarian cancer (OC) depends on lipids as fuel for metastasis and growth. We previously showed that cisplatin resistant (Pt-R) OC cells uptake higher amounts of fatty acids (FAs) compared to sensitive (Pt-S) cells, a process which facilitates cancer cell survival under cisplatin-induced oxidative stress. - Source: PubMed
Publication date: 2026/04/21
Isac Ana MariaValdivia AndresZha DidiWang YinuHernandez VanessaZhao GuangyuanDessai Chinmayee Vallabh PrabhuKim UjinJosyula Annapurna SaiQiang WenanOrsulic SandraCheng Ji-XinMatei Daniela - The risk-benefit profile of mitoxantrone (MTO) in clinical settings is substantially limited by dose-limiting toxicities and a constrained therapeutic index. Human serum albumin (HSA) is an attractive carrier for chemotherapeutics, but its weak affinity for MTO hampers formulation stability and efficacy. To address this challenge, we developed an HSA-binding moiety engineering strategy by conjugating fatty alcohols (FAs, C, C, C) to MTO through disulfide linkages, thereby introducing a high-affinity "molecular anchor" for HSA while ensuring tumor-selective drug release. These conjugates were formulated with HSA at varying mass ratios to optimize the nanoparticle assembly. Structure-activity analysis revealed that elongating FA chains significantly improved albumin affinity, nanoparticle stability, and therapeutic efficacy. The lead candidate, MTO-C, exhibited optimal performance, forming stable HSA nanoparticles with enhanced pharmacokinetics, tumor accumulation, and antitumor potency. At an MTO-equivalent dose of 5 mg/kg, MTO-C@HSA nanoparticles achieved robust tumor suppression with minimal off-target toxicity. This study introduces a versatile approach to enhance the therapeutic outcome of MTO and offers a broadly applicable platform for chemotherapeutics facing similar clinical challenges. - Source: PubMed
Publication date: 2026/04/16
Dai YuebinLi LingxiaoSun NanZhang JingxuanHuang YunlongHuang MinglongFang HongkaiXing JialinSun BingjunSun Jin - Lipids constitute the majority of brain dry weight and play essential structural and signaling roles. During early life, their supply depends largely on breast milk, yet how milk composition aligns with brain fatty acids (FA) across species has not been systematically explored. We analyzed 837 milk samples from seven mammalian species and 194 brain samples from five species using LC-MS. We identified 81 FA in milk and 33 in brain, with 31 shared across both tissues. FA composition in milk and brain was strongly correlated, particularly in humans and macaques, with the strongest associations observed in the prefrontal cortex and during the first four weeks postpartum. Humans were uniquely enriched in very- and ultra-long-chain unsaturated FAs (≥24 carbons) in both milk and brain, suggesting a role in species-specific neurodevelopment. Infant formula clustered closer to bovids than to human milk, underscoring compositional differences of potential nutritional relevance. These findings reveal conserved and human-specific features of milk and brain FAs, highlight the importance of early milk supply for neurodevelopment, and provide evolutionary and translational insights into infant nutrition. - Source: PubMed
Publication date: 2026/04/22
Mitina AleksandraWang YunmeiMair WaltraudVanyushkina AnnaAnikanov NickolayEfimova OlgaGuo SongMazin PavelKhaitovich Philipp