Ask about this productRelated genes to: CD86 antibody
- Gene:
- CD86 NIH gene
- Name:
- CD86 molecule
- Previous symbol:
- CD28LG2
- Synonyms:
- B7.2, B7-2
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-07
- Date modifiied:
- 2016-10-05
Related products to: CD86 antibody
Related articles to: CD86 antibody
- This research aimed to find the optimal sterilization process for ovarian decellularized extracellular matrix (OV-dECM). OV-dECM was prepared. Four different sterilization processes, such as ultraviolet ray, 1 mg/L CuCl + 0.5% HO, 70% ethanol, and 0.1% peracetic acid (PAA), were evaluated. The sterilization efficiency and the and biocompatibility were assessed. Hematoxylin and eosin, 4',6-diamidino-2-phenylindole staining, and DNA quantitation indicated the successful production of OV-dECM. 0.1% PAA and 70% ethanol achieved better sterilization. The sterilized OV-dECM in the 70% ethanol and 0.1% PAA groups could integrate with human umbilical cord mesenchymal stem cell (between them: 7 days: = 0.187; 10 days: = 0.293; both > 0.05) and keep the cell viability (CCK-8, cell counting kit-8) and cell morphology (F-actin staining). The sterilized OV-dECM in both 70% ethanol and 0.1% PAA groups had good CD31 (a neovascularization maker) fusion indexes (between them: = 0.288; > 0.05), while α-smooth muscle actin (another neovascularization maker) in the 0.1% PAA group was higher than that in the 70% ethanol group (between them: = 0.012; < 0.05). The assessment of CD68, CD86, and CD206 (macrophage phenotype makers) demonstrated that the 0.1% PAA group had better chance to promote the M1-M2 transformation of macrophage than 70% ethanol after the implantation of OV-dECM in mice. In conclusion, 0.1% PAA is the optimal sterilization process for OV-dECM with better sterilization capacity and biocompatibility. - Source: PubMed
Publication date: 2026/05/09
Long MeyLignTouch AnitaYang YouLi XiaohongXiao Zhun - Renal carcinoma remains a highly lethal malignancy, and tumor vaccine efficacy is frequently hampered by a profoundly immunosuppressive tumor microenvironment. V-domain Ig suppressor of T-cell activation (VISTA), an inhibitory immune checkpoint enriched in myeloid cells and regulatory T cells (Tregs), represents a critical barrier to effective antitumor immunity. Targeting VISTA may therefore provide a promising strategy to overcome immune suppression and enhance tumor vaccine efficacy. - Source: PubMed
Publication date: 2026/05/08
Wang JiaweiWang ZhenzhenZhao WantingChen HaominLu BowenShao YingxiangZheng YanyanLiu ShanshanWang MengFang LinLi HuizhongNeeli PraveenTian HuiWang GangChai Dafei - Prostate-specific membrane antigen (PSMA)-based vaccination represents a promising immunotherapeutic strategy for prostate cancer; however, its efficacy remains constrained by tumor-induced immune evasion and insufficient activation of antigen-presenting cells. Galectin-9 (LGALS9), an immunoregulatory lectin that contributes to immune suppression, is therefore an attractive target for overcoming tumor-induced immune tolerance. - Source: PubMed
Publication date: 2026/05/08
Lu BowenLiu NingZhao WantingChen HaominShao YingxiangLu HaosenLiu ShanshanYang JieZheng YanyanDing JiageChai DafeiMao Lijun - Frequent frictions and overexpressed reactive oxygen-nitrogen species are two prominent barriers to friction-prone diabetic wound healing. Current commercial dressings fail to adaptively replenish the interfacial lubrication and restore immune homeostasis. By mimicking the lubrication and antioxidation properties of cartilage, we develop an engineered polyzwitterionic dressing by upcycling kitchen waste (eggshell membrane, ESM). With the sequential chemical modification of ergothioneine (EGT) and active-ester-contained zwitterionic copolymer, the resulting EP-ESM dressing replenishes interfacial lubrication (μ = 0.0204) by thickening the hydrated fluid film and thinning the tissue fluid. We quantify the mathematical correlation between time-controlled lubrication and responsive EGT release, confirming the improved efficiency of lubrication replenishment and the inherent lubricity of EP-ESM dressing. In addition, it demonstrates enhanced anti-oxidation performance by synergistic proton-transfer and electron-transfer mechanisms, thereby preserving mitochondrial energy metabolism. EP-ESM also exhibit an immunoregulatory property (2.77-fold increment in CD206 and 68.04% reduction in CD86), as analyzed using RNA-sequencing and qPCR. Consequently, in the full-thickness wound at the dorsal neck of diabetic rats, EP-ESM dressing shows a superior spatiotemporal healing performance compared with pristine ESM and commercial Tegaderm dressings, as evidenced by the increased wound closure rate, more collagen deposition and mature, and rapid angiogenesis. This study offers a promising regenerative strategy that integrates immunoregulation with dynamic lubrication replenishment for chronic wound repair and other tribological diseases. - Source: PubMed
Publication date: 2026/04/20
Yu PengLi YanyanLiu YanpengMa ZhengxinJiang YifeiLu BingyangSun QiangqiangWang Dehui - Melatonin (MT) can regulate the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), but its effect on the osteogenic differentiation of BMSCs under high glucose (HG) conditions is unclear. Therefore, in this study, the effect of MT on the osteogenic differentiation of BMSCs under HG conditions was investigated. - Source: PubMed
Publication date: 2026/05/07
Zhang JimeiZhu LingZhou JianpingYu QunyingYang GuangyuanLuo ChaoliMeng JianguoMao KewangLiu JingMou DonggangYang Xuming