Ask about this productRelated genes to: CD70 antibody
- Gene:
- CD70 NIH gene
- Name:
- CD70 molecule
- Previous symbol:
- CD27LG, TNFSF7
- Synonyms:
- CD27L
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2016-10-05
Related products to: CD70 antibody
Related articles to: CD70 antibody
- Not available. - Source: PubMed
Publication date: 2026/10/01
Garciaz Sylvain - Not available. - Source: PubMed
Publication date: 2026/10/01
Lyu TianxinZhang Yanli - CD70 deficiency, mostly recognized by immune dysregulation, hemophagocytic lymphohistiocytosis, lymphoproliferation, and malignancy, was recently associated with severe and accelerated diabetes in mice. Such a causal relationship is not previously reported in humans. The aim of this study is to describe the first case of CD70 deficiency manifesting with severe onset type 1 diabetes mellitus (T1DM). Changes to glycemic control following hematopoietic stem cell transplantation and accompanying autoimmunity are defined. Immunophenotype analysis, next-generation-primary immunodeficiency panel analysis, and Sanger sequencing were conducted. Then, segregation analysis and functional studies were carried out for validation of the homozygous missense variant in . Following confirmation of CD70 deficiency, hematopoietic stem cell transplantation (HSCT) was carried out. A comprehensive review of clinical history, alongside biochemical and immunologic investigations, was carried out to identify the natural history as well as immune and endocrine phenotypes. Presentation of severe-onset T1DM with severe diabetic ketoacidosis, multiorgan dysfunction, and unexplained findings during follow-up (recurrent diabetic ketoacidosis episodes, unexplained recurring skin lesions, and celiac disease) prompted an evaluation for underlying etiology, and CD70 deficiency was diagnosed. Timely HSCT was curative for CD70 deficiency. Following HSCT, glycemic control was improved (median HbA1c: 8.1% [7.6-8.6] vs 6.5% [5.8-7.0]), total daily insulin dose was reduced from 0.85 to 0.62 U/kg/d, and recurrent episodes of diabetic ketoacidosis ceased. It was concluded that, a homozygous missense variant in CD70, causing CD70 deficiency, may be associated with severe onset T1DM, confirming the significance of intact CD27/CD70 co-stimulation in the prevention of pancreatic -cell autoimmunity. The CD27/CD70 pathway represents a potential target for immunotherapy trials in T1DM. - Source: PubMed
Publication date: 2026/06/22
Unsal YagmurSancak ErtugrulÇelik Ertaş N BernaLangley David BBildik Hacer NeslihanAkarsu AysegülOskay Halacli SevilKaraoglan Dogus VuralliEsenboga SalihaOrhan DiclehanKuskonmaz BarisOkur F VisalGönç E NazlıCagdas DenizOzon Zeynep Alev - Tumor Necrosis Factor Superfamily (TNFSF) comprises 20 members of membrane/soluble signaling proteins regulating cell survival, cell proliferation/differentiation, and innate/adaptive immunity. Targeting signaling of TNFSF members is used clinically to treat several autoimmune and oncological diseases, and bone loss. They and their cognate receptors are in clinical trials as targets for treatment of autoimmune, inflammatory, oncological and other diseases. Recently, some representatives of S100 family of pleiotropic calcium-binding proteins were shown to interact with TNFSF members TNF and TRAIL, thereby suppressing their activity. In this work, we explored selectivity of interactions between soluble forms of 13 TNFSF members and 21 non-fused S100 proteins using surface plasmon resonance spectroscopy. A total of 27 interactions were found between CD70, CD30L, 4-1BBL, TWEAK, APRIL, LIGHT, VEGI and AITRL and Ca2+-loaded forms of S100A1/A2/A4/A5/A6/A12/A16/B/P proteins, with equilibrium dissociation constants from 2 nM to 24 μM. Removal of calcium leads to disruption of the interactions. Molecular docking indicates presence of well-conserved binding sites of the both interaction partners. Mutagenesis of S100P evidences involvement of its 'hinge' region in binding of CD30L, VEGI and AITRL, as well as F89 residue in VEGI recognition. The revealed network of interactions is potentially important for regulation of the cellular communication mediated by TNFSF/S100 proteins, which could be exploited for targeted therapy of socially significant diseases. - Source: PubMed
Publication date: 2026/09/29
Rastrygina Victoria ADeryusheva Evgenia IKazakov Alexey SSokolov Andrey SPermyakova Maria ELitus Ekaterina AUversky Vladimir NPermyakov Eugene APermyakov Sergei E - - Source: PubMed
Publication date: 2026/09/26
Yao YixinLiu YangYan FangfangLi XiaolinLi YijingFei YueMcIntosh JosephLee Heng-HuanWang Michael