Ask about this productRelated genes to: CD69 antibody
- Gene:
- CD69 NIH gene
- Name:
- CD69 molecule
- Previous symbol:
- -
- Synonyms:
- CLEC2C
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-06
- Date modifiied:
- 2016-10-05
Related products to: CD69 antibody
Related articles to: CD69 antibody
- Cervical lymph node metastasis is a major predictor of poor prognosis in patients with oral squamous cell carcinoma (OSCC), underscoring the need for therapies that effectively target metastatic spread. We previously reported that G47Δ, a third-generation oncolytic herpes simplex virus type 1 (HSV-1), rapidly traffics from tongue tumors to cervical lymph nodes and suppresses metastasis in murine models. Based on this lymphotropic property and the immunological significance of CD28-B7-1 interactions for T-cell activation, we pursue the potential of T-mB7-1, a new G47Δ-derived oncolytic HSV-1 expressing soluble murine B7-1. T-mB7-1 secreted soluble B7-1 in vitro without compromising cytopathic activity. In vivo, intratumoral T-mB7-1 suppressed tumor growth in the resistant KLN205-MUC1 subcutaneous model and prolonged survival in SCCVII orthotopic tongue tumors. In the KLN205-MUC1 orthotopic tongue cancer that exhibits rapid lymphatic metastasis, a single dose of T-mB7-1, but not the control virus T-01, significantly reduced cervical lymph node metastasis and improved survival. Repeated low-dose T-mB7-1 further caused near-complete suppression of lymph node metastasis and markedly extended survival. Flow cytometry showed both T-01 and T-mB7-1 induced CD69 T-cell activation in cervical lymph nodes at 18 h, which was reduced with T-mB7-1 at 24 h. Importantly, combining T-mB7-1 with systemic CTLA-4 blockade markedly prolonged survival of mice harboring orthotopic KLN205-MUC1 tumors, with all treated mice surviving beyond 80 days in the otherwise fatal model. These findings demonstrate that soluble B7-1-expressing oncolytic HSV-1 combined with CTLA-4 blockade durably suppresses lymph node metastasis, providing a promising and minimally invasive strategy for regionally metastatic OSCC. - Source: PubMed
Publication date: 2026/05/05
Sugauchi AkinariUchihashi ToshihiroIto HirotakaIwai MiwakoTsurumaki Sato YuzuriKurioka KyokoUsta Sena ZeynepTanaka MinoruKogo MikihikoTanaka SusumuFukuhara HiroshiTodo Tomoki - Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific responses of acute and post-acute COVID-19 patients. Our results indicate that convalescent individuals displayed and maintained higher counts of effector memory, and TEMRA CD4+ T and CD8+ T cells as compared to severe COVID-19. Mild COVID-19 displayed a higher early activation profile in memory subsets as compared to severe and convalescent individuals. Regarding the virus-specific T cell responses, SARS-CoV-2 nucleocapsid protein (N) arose as a major target of CD8+ T cells in convalescent HLA-A*2+ individuals, adding to the specific cellular response mediated by the spike (S) protein. Unsupervised analysis enabled the unbiased clustering of lymphocytes and the assessment of differential expression of CD69, production of intracellular IFN-γ, and reactivity to HLA-A*02 tetramers bearing N or S peptides. Furthermore, cell clones targeting S and N proteins of SARS-CoV-2 undergo cellular expansion in HLA-A*02+ convalescent individuals following in vitro antigenic recall by stimulation with inactivated SARS-CoV-2 and viral proteins. Convalescent from COVID-19 presents higher connectivity of the overall immune response in comparison to the acute phase, regardless of disease severity. Collectively, our data shed new light on the role of the protein N-mediated immunity against SARS-CoV-2 in patients from one of the most affected areas in Brazil. - Source: PubMed
Publication date: 2026/05/05
Lopes-Ribeiro ÁgataMarques-Ferreira GeovanePereira Araujo Franklinde Melo Oliveira PatríciaLourenço Alice AparecidaCardoso Corrêa-Dias LauraPereira Santos Thaíza AlineWilker Teixeira CaioGomes de Pontes Letíciade Melo Rocha Victorde Sousa Reis Erik ViniciusHenriques Pereira SamilleAlves Oliveira Paim AdrianaFlores Andrade Luis AdanMartins da Mata Camila Pacheco SilveiraGuimarães da Fonseca FlávioSantos Coelho Fernanda DanielaPacheco Coelho RafaelPacheco Coelho GabrielPeruhype-Magalhães VanessaTeixeira-Carvalho AndréaMartins-Filho Olindo AssisBeheshti AfshinTsuji MoriyaCoelho-Dos-Reis Jordana Grazziela Alves - Inflammatory arthritis (IA) is a group of autoimmune diseases characterised by joint inflammation and progressive damage, thus impairing the patient's quality of life. The JAK/STAT pathway inhibitor Tofacitinib has been successfully introduced into the clinic to treat patients with IA, however its direct effect on T cell responses is widely unknown. This study aims to assess the effect of Tofacitinib on T cell activation, polyfunctionality, proliferation and metabolism. - Source: PubMed
Publication date: 2026/05/05
Marzaioli VivianaBrugman Aenea A IO'Dowd NiamhFloudas AchilleasGorman AineOrr CarlVeale Douglas JFearon Ursula - Long-term survival after lung transplantation lags behind that of other solid organ transplants, underscoring the need to better understand its complex immune responses to prevent complications and improve clinical outcomes. While most post-transplant immune studies on T lymphocytes have focused on αβ T cells, the role of mucosal-tissue-enriched γδ T cells remains largely unexplored in lung transplantation. - Source: PubMed
Publication date: 2026/04/16
Wang Joshua HYoung TylaLong Katherine DJiao WenyuBay Muntnich ConstanzaPrada Rey AdrianaKhwajazadah MorcelMohan VineethaRogers KortneyValena ArnoldCosta JosephBenvenuto LukeSonett JoshuaLemaitre PhilippeD'Ovidio FrankArcasoy SelimFu Jianing - CD4 T cells play key roles in regulating immune responses during pregnancy; therefore, we aimed to understand the CD4 T-cell surface proteome and transcriptome during pregnancy. - Source: PubMed
Publication date: 2026/04/28
Habel Jennifer RNguyen Thi H Ode Alwis NatashaAllen E KaitlynnLi ShihanSkinner Morgan JJuno Jennifer AKent Stephen JBond KatherineWilliamson Deborah ALappas MarthaHannan Natalie JWalker SusanSchroeder JanCrawford Jeremy ChaseThomas Paul GKedzierska KatherineRowntree Louise C