Ask about this productRelated genes to: CD62L antibody
- Gene:
- SELL NIH gene
- Name:
- selectin L
- Previous symbol:
- LYAM1, LNHR
- Synonyms:
- LSEL, LAM1, LAM-1, hLHRc, Leu-8, Lyam-1, PLNHR, CD62L
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-07
- Date modifiied:
- 2015-08-25
Related products to: CD62L antibody
Related articles to: CD62L antibody
- Aujeszky's disease (AD), caused by suid herpesvirus 1 (pseudorabies virus, PRV), is a highly contagious infection primarily affecting swine, with wild boars serving as an important reservoir in Europe. Spillover infections in non-suid species, including carnivores, are rare but typically fatal and of epidemiological concern. This study presents the first case of AD in a grey wolf () in Central Europe with genomic characterization. The 8-month-old wolf was found in the Carpathians (SE Poland), moribund with acute neurological signs, and euthanized for animal welfare reasons. Necropsy revealed no pathognomonic gross lesions. Molecular analyses of tissues confirmed the presence of PRV DNA using real-time PCR, and virus isolation was successful. Genomic analysis revealed that the PRV isolate clustered within genotype I, the predominant circulating genotype in Europe. However, due to the limited availability of reference PRV genome sequences from European wildlife, the precise geographic origin and transmission pathways of this strain could not be fully resolved. In the presented case, wild boars were considered a possible source of infection. This highlights the potential for PRV transmission to apex predators. This study emphasizes the importance of systematic surveillance of PRV in wildlife and the need for expanded genomic databases of PRV strains. Full-genome sequencing is crucial for improving the understanding of PRV transmission. - Source: PubMed
Publication date: 2026/04/08
Wójcik WojciechDidkowska AnnaOrłowska BlankaNowak SabinaSell BartoszAnusz KrzysztofPfaff FlorianHoffmann Bernd - Renogrit is a prescription medicine developed by employing the traditional knowledge of Ayurveda for the management of kidney disorders. To support its extensive clinical investigations, Renogrit requires robust nonclinical safety assessments. Accordingly, in this study, in vitro mutagenicity assay and in vivo subacute toxicity were conducted as per the Organization for Economic Co-operation and Development (OECD) guidelines. Mutagenic potential of Renogrit was tested using and tester strains in the presence and absence of metabolic activation. DMSO stock solution of Renogrit was assessed at 0.05, 0.15, 0.5, 1.5, and 5.0 mg/plate concentrations, in triplicates, along with the vehicle (DMSO) control and respective positive controls. The revertant colonies were counted after 64- to 72-h incubation period at 37°C. Renogrit was administered to Sprague Dawley (SD) rats by oral route for 28 consecutive days, at the dose levels of 100, 300, and 1000 mg/kg/day. Animals were monitored for all major toxicological parameters, such as morbidity and mortality, clinical signs, body weight, feed consumption, ophthalmological examinations, and functional observational battery (FOB) assessments during the live phase of the study. At study termination, all animals were subjected to hematological analysis, clinical chemistry analysis, examination of organs for gross pathology, and histopathological investigations. The revertant colonies counted in the Renogrit-incubated plates were not significantly increased when compared to vehicle-treated plates, thereby signifying its nonmutagenic potential. Additionally, the subacute toxicity study revealed no toxicologically significant changes attributable to Renogrit administration up to a dose of 1000 mg/kg/day. In conclusion, Renogrit was found to be a nonmutagenic at the evaluated concentrations, and its No Observed Adverse Effect Level (NOAEL) was determined to be 1000 mg/kg/day. The study outcomes provide future nonclinical safety assessments of Renogrit and its detailed clinical evaluation. - Source: PubMed
Publication date: 2026/04/24
Balkrishna AcharyaTiwari AakankshaJangid HimanshuMani KamarajLochab SavitaSinha SandeepVarshney Anurag - The Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative implemented a quality improvement initiative in 2016 to increase multi-arterial graft (MAG) use during isolated coronary artery bypass grafting (CABG). This initiative was associated with a marked increase in MAG utilization compared with historical rates, from 7.4% at baseline to 21.7% in 2019. The present study provides an update on this statewide quality initiative and assesses the safety of MAG with respect to operative mortality and major morbidity as MAG increasingly becomes the default revascularization strategy. - Source: PubMed
Publication date: 2026/04/24
Topcu Ahmet CanHe ChangClark Melissa JAlnajjar Raed MAzoury Fouad MCable David GDeLucia AlphonseSell Timothy LPruitt Andrew LPagani Francis DSchwann Thomas A - The sustainability of packaging has become fundamental for many companies, partly because of increasingly stringent European regulations, such as the Packaging and Packaging Waste Regulation. Companies that want to sell the product through e-commerce are therefore called upon to evaluate and consider the performance and environmental impact of their products. The purpose of this study is to assess the environmental impact of the life cycle of two e-commerce packaging solutions for a book application: a kraft paper bag and a cardboard bag. First, the life cycles of the single packaging solutions were analyzed, then the environmental performances of the two packaging structures were compared. For both solutions, the results show the high impact associated with the materials used to make the bags. The comparative analysis highlighted the lower environmental impact of the kraft paper bag. Because of the importance and high environmental impact of the constituent materials and waste generated during the forming phase, three sensitivity analyses were carried out to investigate this aspect: one on the origin of the material, one on the waste quantity, and one on the energy source used. Regardless of those aspects, the cardboard-based bag appears more impactful than the kraft paper bag. In addition, an uncertainty analysis was carried out to determine the robustness of the dataset used. - Source: PubMed
Publication date: 2026/04/24
Rizzo Maria VittoriaVignali Giuseppe - Helaina human lactoferrin (LF) (effera®) is a potential, well-tolerated alternative for improving iron status in women who present with chronic iron deficiency. This case series reports on two active women who had persistently low iron levels and poor response to, or intolerance of, standard orally administered iron supplements. The two individuals independently started oral ingestion of effera® at 100 mg/day for 6-20 weeks. Both showed notable increases in ferritin, with one also exhibiting marked increases in serum iron and transferrin saturation. The two participants reported better energy, fewer symptoms, and improved exercise capacity, all without gastrointestinal issues. These results align with growing evidence that LF supports iron homeostasis through receptor-mediated absorption, hepcidin-ferroportin modulation, and immune-balancing effects, potentially surpassing or working in synergy with conventional treatments. While limited to case reports, these observations support further controlled trials of effera® as an adjunct or alternative for iron deficiency, including non-anemic presentations. - Source: PubMed
Publication date: 2026/04/21
Evans CassandraPeterson RossAntonio JoseClark Anthony