Ask about this productRelated genes to: CD62P antibody
- Gene:
- SELP NIH gene
- Name:
- selectin P
- Previous symbol:
- GRMP
- Synonyms:
- CD62, PSEL, PADGEM, GMP140, CD62P
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-11-16
Related products to: CD62P antibody
Related articles to: CD62P antibody
- Periodontitis (PD) and ulcerative colitis (UC) are two common chronic inflammatory diseases increasingly connected via the "oral-gut axis," yet their shared molecular mechanisms remain unclear. Oxidative stress, driven by excessive reactive oxygen species (ROS), represents a key pathogenic mechanism common to both PD and UC. In this study, we integrated transcriptomic datasets from patients with PD and UC to identify oxidative stress-related genes underlying their comorbidity. By combining weighted gene co-expression network analysis (WGCNA), machine learning, and single-cell RNA sequencing, we identified and validated a set of comorbidity-associated diagnostic biomarkers: CXCL1, XBP1, CD93, FYN, SELP, and CXCR4. These genes demonstrated high diagnostic accuracy across independent datasets, and gene set enrichment analysis (GSEA) revealed their involvement in inflammatory and immune-related pathways. Single-cell analysis further demonstrated endothelial-specific co-expression of SELP and CD93, highlighting their potential roles in intercellular communication and chronic inflammation. Moreover, molecular docking identified candidate therapeutic compounds with strong binding affinities for these targets. Collectively, our findings elucidate shared oxidative stress-driven mechanisms linking PD and UC and propose novel biomarkers and therapeutic targets for these interconnected diseases. - Source: PubMed
Publication date: 2026/04/10
Wang LingxuGu QiuleDing XuTang ChunboWu Jin - U6 biogenesis 1 (USB1) gene mutations cause poikiloderma with neutropenia (PN), which is clinically characterized by skin hyperpigmentation, nail dysplasia, neutropenia, and an elevated risk of cancer. USB1 functions as an RNA exonuclease involved in RNA maturation and stability regulation, although its precise mechanism of action in the hematopoietic system remains unclear. - Source: PubMed
Publication date: 2026/04/20
Li HangShi GuiyingTang JiamingHuang YiyingWang JieLei XuepeiBai Lin - Hypoxia-inducible factor-1α (HIF-1α) regulates multiple pathways involved in metabolism, inflammation, and coagulation and may contribute to thrombotic complications in patients with BCR::ABL1-negative myeloproliferative neoplasms (MPN). This study investigated the expression of selected HIF-1α-regulated and thrombo-inflammatory genes (SLC2A1, F3, SELP, VEGFA, SERPINE1, PROS1, NLRP3 and THBS1) and their association with thrombotic events, JAK2 mutation status, and cytoreductive therapy. - Source: PubMed
Publication date: 2026/04/16
Morath OlgaWolfrum ThereseCrodel CarlHochhaus AndreasErnst ThomasRinke Jenny - Hepatocellular carcinoma (HCC) is a highly lethal malignancy with high invasiveness and metastasis. Despite progress in its treatment, the high mortality rate persists due to poor prognosis. In this study, we aimed to develop a prognostic model for HCC using platelet-related genes. We downloaded and preprocessed data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Through differential gene expression analysis, univariate Cox regression, Least absolute shrinkage and selection operator (LASSO) machine learning, and multivariate Cox regression, we constructed a prognostic model consisting of six genes (KIF18A, HRG, TUBA4B, MAFF, SELP, and IGF1). The survival analysis and ROC curve evaluation conducted on both the training and validation sets showed excellent predictive performance of the model. In addition, the model was also associated with the malignancy and risk of metastasis of tumors. Additionally, analysis of half maximal inhibitory concentration (IC50) values between high- and low-risk groups for various drugs showed significant differences, suggesting potential differences in predicted drug sensitivity between risk groups. We identified potential stem-like cell subpopulations in HCC cells, which are mostly in the late stage of malignant cell differentiation. In conclusion, we successfully constructed a novel platelet-related prognostic model for HCC. - Source: PubMed
Publication date: 2026/04/13
Pan HongCheng XiDong YongLi Da - Pulmonary arterial hypertension (PAH) is a complex disease with multiple contributing factors. Epidemiological data showed that women are more susceptible to PAH, but they tend to have better right ventricular (RV) function and prognosis compared to men. The mechanisms behind these gender differences are not well understood. Using a variety of bioinformatic techniques, this study was aimed at investigating the major genes and putative pathways driving PAH in females. Consequently, microarray datasets GSE38267 and GSE131793 were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) in patients with PAH and healthy men and females were found via the use of volcano plots and Venn diagrams. Female-specific DEGs were selected for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, with results visualized via R and Cytoscape software. The protein-protein interactions (PPIs) of female-specific DEGs were analyzed using the NetworkAnalyst online tool. Among identified DEGs, 98 DEGs were specific to males, 145 were shared among sexes, and 741 were unique to females. To focus on DEGs that are specific to female, male and shared DEGs were excluded. GO enrichment analysis revealed that these DEGs in females were mostly involved in cell-matrix adhesion, mucosal innate immune response, and hydrogen peroxide catabolism. Significant KEGG pathways included fluid shear stress, atherosclerosis, arrhythmogenic RV cardiomyopathy, and ECM-receptor interaction. Bioinformatic analysis of microarray datasets led to the identification of 10 female-specific hub genes, SLC4A1, THBS1, ITGB3, IL7R, CCR7, SNCA, CTNNB1, SELP, GZMK, and ITGA2B, from DEGs between control and PAH samples in females. These hub genes that are specific to females have the potential to be significant in the pathogenesis of PAH in females. These hub genes may be promising candidates for improving our knowledge of sex-related processes in PAH; nevertheless, experimental confirmation is necessary before considering them as biomarkers or therapeutic targets. - Source: PubMed
Panahi MohammadKalhor ReyhanehMokhtarian Mohammad-HosseinTehrani Fatemeh JavaheriShams ZinatKalhor Hourieh