Ask about this productRelated genes to: CD49f antibody
- Gene:
- ITGA6 NIH gene
- Name:
- integrin subunit alpha 6
- Previous symbol:
- -
- Synonyms:
- CD49f
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2015-12-15
Related products to: CD49f antibody
Related articles to: CD49f antibody
- Epithelial barrier disruption is a hallmark of allergic skin diseases. Sodium dodecyl sulfate (SDS), a surfactant in household cleaning products, is known to impair the barrier. - Source: PubMed
Publication date: 2026/05/17
Li ManruBabayev HuseynD'Avino PaoloZeyneloğlu CanBicer CerenYazici DuyguPat YagizSvedenhag PerGaudenzio NicolasAkdis Cezmi AMitamura Yasutaka - Antioxidant supplementation during in vitro maturation (IVM) has been proposed as a strategy to influence transcriptional responses in oocytes and cumulus-oocyte complexes. In this study, we investigated whether vitamin C, rosmarinic acid, or quercetin influence the expression of key fertilisation-associated genes (, , , , and ) in porcine cumulus-oocyte complexes (COCs). COCs were classified into three intrinsic quality groups (I-III) and matured in the presence or absence of antioxidants. Gene expression was quantified by RT-qPCR and analysed using a two-way ANOVA model to assess the effects of COC quality and treatment. and transcript levels were consistently lower in class II and III COCs than in class I controls ( < 0.001). Antioxidant supplementation was associated with treatment- and quality-dependent differences in gene expression. Quercetin was associated with the most pronounced upregulation, with Q I increasing expression to 2.95-fold and to 2.43-fold relative to class I controls ( < 0.001). Vitamin C was also associated with increased transcript abundance across several treatment groups, including class II and class III COCs, whereas rosmarinic acid exhibited more moderate and gene-specific effects. In contrast, expression, which was elevated in lower-quality COCs, was reduced in antioxidant-treated class II and III complexes. These findings provide transcript-level evidence that antioxidant exposure during IVM is associated with treatment- and quality-dependent changes in fertilisation-related gene expression in porcine COCs. - Source: PubMed
Publication date: 2026/04/24
Boldura Oana-MariaMarc SimonaMircu CălinHuțu IoanCocoș DaianaVizitiu Dorin AlexandruSavici Jelena - Non-small cell lung cancer (NSCLC) contains rare cancer stem cells (CSCs) that contribute to relapse and drug resistance. Bulk RNA-seq overlooks these cells due to its averaging of expression across all cell types, whereas standard single-cell RNA-seq (scRNA-seq) analyses often struggle to reliably identify these rare CSC states. To address this, we developed an scRNA-seq pipeline that integrates machine learning with explainable AI (XAI) to detect CSC-like epithelial cells in NSCLC (GSE198099, n = 2 patients; analyses supported by effect size-based validation despite limited statistical power). Patient-derived scRNA-seq profiles underwent quality control and batch correction using scVI, and annotated using CellTypist. A 45-gene stemness score was used to identify candidate CSC-like states. Four machine learning models (Logistic Regression, LightGBM, XGBoost, and CatBoost) were trained to refine the CSC-like state identification. SHAP-based feature attribution analyses converged on six key biomarkers: DLL1, ITGA6, ATXN2, NOTCH1, DCLK1, and PUM1. These biomarkers are involved in regulating transcription, adhesion, cytoskeletal dynamics, and post-transcriptional control. Pathway analysis and validation using TCGA validation data provided supportive evidence for the biological relevance of these biomarkers. This framework provides a methodologically reproducible approach to reveal rare CSC-like states with improved mechanistic clarity, providing candidate biomarkers for studying NSCLC tumor plasticity. - Source: PubMed
Publication date: 2026/04/22
Munisankar SharathKumar RThiyagaraj Anand - Unicentric Castleman disease (UCD), a rare lymphoproliferative disorder, is frequently complicated by paraneoplastic pemphigus (PNP), an autoimmune mucocutaneous syndrome with high mortality. The hyaline-vascular (HV) histological subtype predominates in UCD-PNP, yet the mechanisms driving vascular hyalinization and stromal dysregulation remain poorly defined. - Source: PubMed
Publication date: 2026/04/20
Wang SaiWang RuiYang YinmoDong YujunShang PanpanChen XixueZhu XuejunWang YangZhang GuohongWang Mingyue - The ovary is a central female reproductive organ responsible for producing oocytes and secreting steroid hormones. To investigate the molecular similarities and potential evolutionary origins of the ovary across vertebrates, we integrated publicly available single-cell and single-nucleus transcriptomic data from nine species, including oviparous animals (fish and chicken) and viviparous mammals (mouse, rat, sheep, goat, yak, monkey, and human). - Source: PubMed
Publication date: 2026/04/14
Xue BailingLiu YajingZhou ChenDossybayev KairatBaatar NarantuyaYudin NikolayZhang LinweiYang JiLi MenghuaXu Songsong