Ask about this productRelated genes to: CD43 antibody
- Gene:
- SPN NIH gene
- Name:
- sialophorin
- Previous symbol:
- -
- Synonyms:
- LSN, CD43, GPL115
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-31
- Date modifiied:
- 2016-07-19
Related products to: CD43 antibody
Related articles to: CD43 antibody
- Streptococcus pneumoniae (Spn) is one of the major pathogens responsible for morbidity and mortality worldwide, and pneumococcal diseases constitute a significant global public health burden, with a particularly high burden among children under five years of age and older adults. Based on differences in the structure of capsular polysaccharides, more than 100 pneumococcal serotypes have been identified to date. The pathogenicity of Spn is, to some extent, associated with immune evasion mediated by serotype-specific capsular polysaccharides; therefore, pneumococcal vaccines covering multiple serotypes have significant public health importance for the prevention and control of related diseases. With the promotion and application of pneumococcal vaccines in China, the serotype distribution of Spn has undergone dynamic changes, and serotype-specific epidemiological evidence as well as real-world evidence on vaccine use has continued to accumulate. This study systematically reviews the distribution characteristics of Spn serotypes and related diseases in China, as well as the current status of antimicrobial resistance; describes the immune protective mechanisms of pneumococcal conjugate vaccines (PCVs) against different serotypes; compares the immunogenicity and protective effects of PCVs with different valences; and discusses the development directions and key scientific issues of higher-valent PCVs and universal pneumococcal vaccines, in order to provide evidence reference and scientific support for the design of PCV serotype coverage and the optimization of immunization strategies in China. - Source: PubMed
Publication date: 2026/05/08
Fan C LZheng HZeng MHe H QWang LLiu YZhang C HXu Q FLi Y ZFu C X - This study compared the diagnostic performance and safety of computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB) and virtual bronchoscopic navigation (VBN)-guided transbronchial lung biopsy (TBLB) in patients with solitary pulmonary nodules (SPNs). - Source: PubMed
Publication date: 2026/04/22
Zhao WeiLiu ChenHu YajieDu YanhongZhang Yunhui - Hydrolyzed rice formulas (HRF) are a suitable option for the nutritional management of non-breastfed children with cow's milk allergy (CMA). Human milk oligosaccharides (HMOs) enhance gastrointestinal health, promote the growth of beneficial gut microbiota, and may reduce the incidence of infections and antibiotic use. There is currently no evidence regarding the hypoallergenicity of HRF containing HMOs. The purpose of this study is to demonstrate the hypoallergenicity of a new hydrolyzed rice protein-based formula containing two manufactured HMOs (HRF-HMO). RIGHT-HY is a multi-center randomized controlled study enrolling infants and children (60 days-3 years) with documented Immunoglobulin E-mediated CMA. Children will be randomized in a crossover fashion to double-blind placebo-controlled food challenges (DBPCFC) with HRF-HMO and an amino acid-based formula (AAF)-HMO, followed by a 7-days open challenge with HRF-HMO requiring a daily minimum intake of 240 ml. Both formulas contain 2-fucosyllactose and lacto-N-neotetraose (1.5 g/L). The primary objective is to demonstrate with 95% confidence that 90% of children with CMA do not develop allergic reactions to HRF-HMO under DBPCFC conditions. Up to 67 children will be enrolled to meet the hypoallergenicity criteria. This sample size allows for a 10% drop-out rate and occurrence of one allergic reaction. An interim analysis will be performed after 42 children have completed both food challenges to assess whether hypoallergenicity criteria have been met, in which case, the study will be stopped for success. Secondary endpoints include HRF-HMO intake and gastrointestinal tolerance during the week-long open challenge, and adverse events throughout the study. The RIGHT-HY study was approved by ethical committees of all participating sites. This study will be the first to generate robust evidence on the hypoallergenicity of this rice formula with added HMOs in children with CMA. The results of the study will be disseminated in peer-reviewed publications and presentations at scientific conferences. - Source: PubMed
Publication date: 2026/04/22
Zemrani BoutainaHays Nicholas PD'Auria EnzaMori FrancescaKalb BirgitDarwish NouraEsposito SusannaBrzozowska AgnieszkaJedynak-Wasowicz UrszulaBeyer KirstenSzajewska HaniaCanani Roberto Berni - Breast cancer surgery is frequently associated with moderate to severe postoperative pain. While the serratus anterior plane block (SAPB) provides effective anterolateral chest wall analgesia, it may inadequately cover the anterior intercostal nerve branches. This study aimed to determine whether adding a superficial parasternal intercostal plane block to SAPB improves postoperative opioid consumption, pain scores, and dermatomal sensory coverage. - Source: PubMed
Publication date: 2026/05/07
Akbulut Fazil AhmetKürşad HüsnüSözüak Muhammed EminAhiskalioglu Ali - Here, we examine immune signaling pathways affecting the duration of primary nasopharyngeal colonization by Streptococcus pneumoniae (Spn), the first step in its pathogenesis. Spn colonization which lasts days to weeks in WT mice was persistent (> 6 months) in the absence of IL-17RA-signaling. RNA-seq analysis confirmed the role of IL-17RA signaling in neutrophil-associated pathways. The onset of clearance required neutrophils, but there was no detectable increase in their numbers. IL-17RA-signaling was required to replenish neutrophils in nasal tissue that were otherwise depleted during infection. Enhanced neutrophil trafficking correlated with IL-17RA-dependent expression of endothelial cell adhesion molecules that promote neutrophil trafficking from the circulation into nasal tissue. Persistent colonization was also observed in mice lacking IL-1R-signaling. Recognition of IL-1-family cytokines, however, was not necessary for the expression of IL-17A or neutrophil recruitment. Instead, IL-1R-signaling was associated with the activation of neutrophils in nasal tissue that displayed increased levels of the surface marker CD11b, an important receptor for the complement-opsonized phagocytosis of Spn. Colonization of dual-knockout mice showed the contributions of IL-1 and IL-17 signaling pathways were non-redundant. Expression of the chemokine Cxcl5 was impaired in the absence of either IL-1R or IL-17RA signaling, suggesting a role in both activation and maintenance of the neutrophil population during infection. Our findings provide insight into the requirement for sustained neutrophil presence and activity to prevent persistent mucosal infection by a leading opportunistic mucosal pathogen. - Source: PubMed
Publication date: 2026/05/05
Idowu TeniolaLokken-Toyli KristenYeung StephenWeiser Jeffrey N