Ask about this productRelated genes to: ZFAND2B antibody
- Gene:
- ZFAND2B NIH gene
- Name:
- zinc finger AN1-type containing 2B
- Previous symbol:
- -
- Synonyms:
- AIRAPL
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-22
- Date modifiied:
- 2016-02-12
Related products to: ZFAND2B antibody
Related articles to: ZFAND2B antibody
- This study aimed to identify causal variants associated with important carcass traits such as weight and meat quality in Hanwoo cattle. We analyzed missense mutations extracted from imputed sequence data () and performed an exon-specific association test on the carcass traits of 16,970 commercial Hanwoo. We found 33, 2, 1, and 3 significant SNPs associated with carcass weight (CW), backfat thickness (BFT), eye muscle area (EMA), and marbling score (MS), respectively. In CW and EMA, the most significant missense SNP was identified at 19,524,263 on BTA14 and involved the . A missense SNP in the , located at 107,160,304 on BTA2 was identified as being involved in BFT. For MS, missense SNP in the gene, located at 11,849,704 in BTA22 was identified as the most significant marker. The contribution of the most significant missense SNPs to genetic variance was confirmed to be 8.47%, 2.08%, 1.73%, and 1.19% in CW, BFT, EMA, and MS, respectively. We generated favorable and unfavorable haplotype combinations based on the significant SNPs for CW. Significant differences in GEBV (Genomic Estimated Breeding Values) were observed between groups with each favorable and unfavorable haplotype combination. In particular, the missense SNPs in , , and appear to significantly affect the protein's function and structure, making them strong candidates as causal mutations. These missense SNPs have the potential to serve as valuable markers for improving carcass traits in Hanwoo commercial farms. - Source: PubMed
Publication date: 2023/09/22
Lee Dong JaeKim YoonsikDinh Phuong Thanh NChung YoonjiLee DoohoKim YeongkukLee Soo HyunChoi InchulLee Seung Hwan - Breast cancer is one of the most common malignancies among women. Recent studies revealed that differentially methylated regions (DMRs) are implicated in regulating gene expression. The goal of this research was to determine which genes and pathways are dysregulated in breast cancer when their promoters are methylated in an abnormal way, leading to differential expression. Whole-genome bisulfite sequencing was applied to analyze DMRs for eight peripheral blood samples collected from five Saudi females diagnosed with stages I and II of breast cancer aligned with three normal females. Three of those patients and three normal samples were used to determine differentially expressed genes (DEG) using Illumina platform NovaSeq PE150. - Source: PubMed
Publication date: 2023/07/06
Sindi SamarHamdi NorahHassan SabahGanash MagdahAlharbi MonaAlburae NajlaAzhari SherenAlkhayyat ShadiLinjawi AymanAlkhatabi HebaElaimi AishaAlrefaei GhadeerAlsubhi NoufAlrafiah AzizaAlhazmi Safiah - Myeloproliferative neoplasms (MPNs) represent a frequently occurring group of heterogeneous hematologic malignancies. In the last decade, the identification of JAK2-activating mutations in a significant proportion of MPN patients gave rise to the first molecularly driven therapy for BCR-ABL-negative patients. Nevertheless, current efforts are still focused on the identification of novel therapeutic targets to achieve permanent remission. In this perspective, we focus on the recent findings in this field and highlight new evidence linking proteostasis deregulation with myeloid transformation. We recently reported that the proteostasis regulator AIRAPL acts as a tumor suppressor in MPNs through the modulation of insulin-like growth factor receptor levels at the endoplasmic reticulum. This finding paves the way for new therapeutic approaches to these neoplasms and indicates the importance of protein homeostasis maintenance for normal hematopoiesis. - Source: PubMed
Publication date: 2016/04/14
Santiago-Fernández OlayaOsorio Fernando GLópez-Otín Carlos - Lys48-linked ubiquitin chains act as the main targeting signals for protein degradation by the proteasome. Here we report selective binding of AIRAPL, a protein that associates with the proteasome upon exposure to arsenite, to Lys48-linked tri-ubiquitin chains. AIRAPL comprises two ubiquitin-interacting motifs in tandem (tUIMs) that are linked through a flexible inter-UIM region. In the complex crystal structure UIM1 binds the proximal ubiquitin, whereas UIM2 (the double-sided UIM) binds non-symmetrically to the middle and distal ubiquitin moieties on either side of the helix. Specificity of AIRAPL for Lys48-linked ubiquitin chains is determined by UIM2, and the flexible inter-UIM linker increases avidity by placing the two UIMs in an orientation that facilitates binding of the third ubiquitin to UIM1. Unlike middle and proximal ubiquitins, distal ubiquitin binds UIM2 through a novel surface, which leaves the Ile44 hydrophobic patch accessible for binding to the proteasomal ubiquitin receptors. - Source: PubMed
Publication date: 2016/02/11
Rahighi SiminBraunstein IlanaTernette NicolaKessler BenediktKawasaki MasatoKato RyuichiMatsui TsutomuWeiss Thomas MStanhill ArielWakatsuki Soichi - AIRAPL (arsenite-inducible RNA-associated protein-like) is an evolutionarily conserved regulator of cellular proteostasis linked to longevity in nematodes, but its biological function in mammals is unknown. We show herein that AIRAPL-deficient mice develop a fully-penetrant myeloproliferative neoplastic process. Proteomic analysis of AIRAPL-deficient mice revealed that this protein exerts its antineoplastic function through the regulation of the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway. We demonstrate that AIRAPL interacts with newly synthesized insulin-related growth factor-1 receptor (IGF1R) polypeptides, promoting their ubiquitination and proteasome-mediated degradation. Accordingly, genetic and pharmacological IGF1R inhibitory strategies prevent the hematological disease found in AIRAPL-deficient mice as well as that in mice carrying the Jak2(V617F) mutation, thereby demonstrating the causal involvement of this pathway in the pathogenesis of myeloproliferative neoplasms. Consistent with its proposed role as a tumor suppressor of myeloid transformation, AIRAPL expression is widely abrogated in human myeloproliferative disorders. Collectively, these findings support the oncogenic relevance of proteostasis deregulation in hematopoietic cells, and they unveil novel therapeutic targets for these frequent hematological neoplasias. - Source: PubMed
Publication date: 2015/12/21
Osorio Fernando GSoria-Valles ClaraSantiago-Fernández OlayaBernal TeresaMittelbrunn MaríaColado EnriqueRodríguez FranciscoBonzon-Kulichenko ElenaVázquez JesúsPorta-de-la-Riva MontserratCerón JuliánFueyo AntonioLi JuanGreen Anthony RFreije José M PLópez-Otín Carlos