Ask about this productRelated genes to: VCAM1 antibody
- Gene:
- VCAM1 NIH gene
- Name:
- vascular cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- CD106
- Chromosome:
- 1p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2016-10-05
Related products to: VCAM1 antibody
Related articles to: VCAM1 antibody
- Long COVID, a major post-acute infection syndrome (PAIS), characterized by prolonged or new-onset symptoms following acute COVID-19, critically affects patients' quality of life. Establishing easily measurable and objective biomarkers that reflect disease severity is essential for clinical management. This retrospective cohort study evaluated serum levels of growth differentiation factor 15 (GDF-15), a mitochondrial stress marker, and vascular cell adhesion molecule-1 (VCAM-1), a vascular endothelial stress marker, in 32 patients with Long COVID who presented with persistent systemic or neurological symptoms and had not required acute-phase hospitalization. Serum GDF-15, VCAM-1, and inflammatory cytokine levels were measured at the initial visit and at 3 and 6 months. Differences between patients who recovered at 6 months and those who did not (non-improved group) were analyzed using linear mixed-effects models (LMMs). Most inflammatory cytokines remained near their lower detection limits and were excluded from the longitudinal analysis. The LMMs revealed sustained elevation of both GDF-15 ( = 0.02) and VCAM-1 ( = 0.03) levels in the non-improved group. These findings suggest that longitudinal tracking of these two markers may offer clinically relevant insights into disease activity and treatment-resistant pathophysiology in mild acute-phase Long COVID. - Source: PubMed
Publication date: 2026/08/20
Ono RieTakayama ShinAbe MichiakiArita RyutaroOnodera KohIshizawa KotaKanno TakeshiSaito NatsumiKikuchi AkikoAbe TakaakiIshii Tadashi - Extramedullary hematopoiesis is increasingly recognized as an important mechanism by which peripheral tissues augment immune responses during inflammation and infection. However, the mechanisms governing recruitment, retention, and local differentiation of circulating hematopoietic stem and progenitor cells (HSPCs) within human tissues remain poorly understood due to the lack of physiologically relevant experimental models. Here, we developed a human skin-on-a-chip microphysiological platform to investigate the role of circulating hematopoietic stem and progenitor cells (HSPCs) in cutaneous immune responses and their potential contribution to extramedullary hematopoiesis. The device recapitulates key features of human skin, including a perfusable vascular endothelium, fibroblast-populated dermis, and keratinocyte epidermis. Upon stimulation with pro-inflammatory cytokines or a TLR2 agonist, endothelial activation significantly increased ICAM-1 and VCAM-1 expression and enhanced recruitment of both neutrophils (PMNs) and HSPCs. While PMNs readily underwent transendothelial migration into the dermal compartment, HSPCs remained localized to the vascular niche. Notably, HSPCs adhered robustly and persisted on inflamed endothelium independent of SDF-1/CXCR4 signaling. Under granulopoietic conditions, these retained HSPCs differentiated locally within the vascular compartment into PMN-like cells capable of phagocytosis and exhibiting pathogen-responsive gene expression profiles. These findings provide evidence in a human model that circulating HSPCs can contribute to host defense localized granulopoiesis without tissue infiltration, and suggests that the vascular niche itself may serve as a site of immune cell production during infection. The platform further offers a foundation for developing HSPC-based therapeutic strategies to combat antibiotic-resistant skin infections. - Source: PubMed
Publication date: 2026/09/03
Cirves Evan PWallace Stormy KChiaramonte Bella SJudy MadisonShirure Venktesh SShergill Bhupinder SGeorge Steven C - Chronic Rhinosinusitis (CRS) shares epidemiological links with Cardiovascular Diseases (CVDs), however, their shared genetic basis remains unclear. We hypothesized that pleiotropic genetic variants underlie CRS-CVDs links via distinct biological pathways. - Source: PubMed
Publication date: 2026/09/02
Wei BoHe JiaoyuGan WeigangWang BinbinLiu Feng - A simple and convenient approach involving visible-light-induced, TBHP-mediated oxidation of propargyl alcohols to ynone in aqueous media has been developed. This photoinduced protocol was conducted under an aerobic-aqueous medium using Eosin Y as a photosensitizer. A diverse range of ynone derivatives were prepared from propargyl alcohol in moderate to excellent yield. Furthermore, the successful gram-scale experiment of this method also indicates its flexibility and applicability for industrial applications. Steric mapping of the series 2a-2q, exemplified by 2j, revealed an optimized buried volume and three-dimensional bulk distribution that closely mimics the reference PKC inhibitor while surpassing the less efficient steric profiles of the MSY and VCAM1 analogues. In addition, an exit vector analysis was carried out to get a clearer insight into the substituent orientation and spatial vector divergence. - Source: PubMed
Bera BimanHalder ArabindaKumar PradeepVasudev Prema GSaid Musa ABera Mrinal K - The endothelium maintains vascular health by regulating blood flow and protecting against inflammatory damage. In type 2 diabetes (T2DM), however, hyperglycemia, hypertension, and hyperlipidemia place a significant burden on the endothelium, potentially leading to atherosclerosis and cardiovascular disease (CVD). While semaglutide and empagliflozin have been shown to reduce CVD risk in T2DM, it remains unclear whether these benefits are mediated by improved endothelial function. This post-hoc analysis explores the effects of these agents on markers of endothelial function, i.e. the reactive hyperaemic index (RHI) and the endothelial-derived cell adhesion molecules (CAMs) E-Selectin, ICAM-1, P-Selectin, and VCAM-1. - Source: PubMed
Publication date: 2026/08/29
Gullaksen SørenVernstrøm LivSørensen Steffen SkovgaardFunck Kristian LøkkePoulsen Per LøgstrupLaugesen Esben