Ask about this productRelated genes to: UBXN2B antibody
- Gene:
- UBXN2B NIH gene
- Name:
- UBX domain protein 2B
- Previous symbol:
- -
- Synonyms:
- p37
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2008-07-25
- Date modifiied:
- 2014-11-19
Related products to: UBXN2B antibody
Related articles to: UBXN2B antibody
- Skeletal muscle plays a crucial role in maintaining normal physiological function and body weight in pigs. However, the complexity of the skeletal muscle transcriptome at the isoform level and its underlying genetic regulatory mechanisms remains largely unexplored. - Source: PubMed
Publication date: 2026/03/03
Hu JianchaoDing ZifengYao TianxiongZou XiaoxiaoWu Zhongzi - Fertility, growth and body composition are key drivers of profitability in beef cattle. With the aim of identifying causative mutations underpinning variation in these traits, we integrated multi-trait genome-wide association analysis (M-GWAS) in a cohort of 28,351 multibreed beef cattle with imputed whole genome sequence (WGS) data, with expression quantitative trait loci (eQTL) summary statistics from 489 indicine cattle using the same WGS variants. An additional aim was to provide insights into the biological basis for the association between growth, metabolism, and reproductive development. First, we conducted M-GWAS for live weight, hip height, body condition score and heifer puberty at approximately 600 days. Subsequently, focusing on a 2 Mb region around the lead GWAS SNP we identified the top eQTL in each region. Through iterative conditional analysis, we successively integrated these variants into individual single trait GWAS and further analysed expression and trait information using conditional and joint GWAS analysis. This iterative process continued until no additional significant SNPs emerged from the M-GWAS. - Source: PubMed
Publication date: 2025/10/07
Forutan MehrnushRoss Elizabeth MChamberlain Amanda JFordyce GeoffryEngle Bailey NNguyen Loan THayes Ben J - Metabolic dysfunction-associated steatotic liver disease (MASLD) may progress to liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma. So far, genome-wide association studies explain a small fraction of MASLD heritability. - Source: PubMed
Publication date: 2025/06/02
Jamialahmadi OveisMujica EndrinaMorris LowriMancina Rosellina MargheritaCiociola EsterQadri Sami FMaurotti SamanthaMalvestiti FrancescoLi-Gao RuifangRonzoni LuisaTavaglione FedericaMaude HannahAllalou AminEmmanouilidou AnastasiaVespasiani-Gentilucci UmbertoRosendaal Frits RichardYki-Järvinen HanneleCebola InêsValenti LucaHoed Marcel denRomeo Stefano - China has abundant local duck resource populations, and evaluating the characteristics of these breeds will help improve development and utilization. In this study, we conducted the first investigations of growth and slaughter performance on Sichuan Shelduck (n = 240), an endangered duck local breed. The average body weight is 1497.91 g at 90 d of age. According to the growth curve through data recorded every 2 wk, we observed a low relative growth rate (RGR) for the early growth stage. The RGR shows a decreasing trend with age increasing in the stage from 0 to 56 d of age. The SNP-based heritability estimation showed the growth rate has a relatively high heritability, indicating high genetic stability for this trait. In the correlation analysis, the percentage of leg muscle is positively correlated with the absolute growth rate (AGR) at 28 to 42 d of age, whereas it is negatively correlated with the earlier stages, exhibiting a time-specific correlation result. Additionally, genome-wide association studies (GWAS) identified PCSK6, TOX2, and TOMM7 as potential candidate genes influencing AGR (42-56) and AGR (56-90), while the candidate genes of slaughter traits were PTP4A2, FAM110B, TOX, UBXN2B, and FCHSD2. These results provide an important reference for further understanding the genetic basis of growth and meat production performance of Sichuan Shelduck. - Source: PubMed
Publication date: 2024/08/14
Yang ZhaoXi YangQi JingjingLi LiangBai LiliZhang JunLv JiaLi BoLiu Hehe - Copy number variation (CNV) serves as a significant source of genetic diversity in mammals and exerts substantial effects on various complex traits. Pingliang red cattle, an outstanding indigenous resource in China, possess remarkable breeding value attributed to their tender meat and superior marbling quality. However, the genetic mechanisms influencing carcass and meat quality traits in Pingliang red cattle are not well understood. We generated a comprehensive genome-wide CNV map for Pingliang red cattle using the GGP Bovine 100K SNP chip. A total of 755 copy number variable regions (CNVRs) spanning 81.03 Mb were identified, accounting for approximately 3.24% of the bovine autosomal genome. Among these, we discovered 270 potentially breed-specific CNVRs in Pingliang red cattle, including 143 gains, 73 losses, and 54 mixed events. Functional annotation analysis revealed significant associations between these specific CNVRs and important traits such as carcass and meat quality, reproduction, exterior traits, growth traits, and health traits. Additionally, our network and transcriptome analysis highlighted , , , , , and as promising candidate genes associated with carcass weight and intramuscular fat deposition. The current study presents a genome-wide CNV map in Pingliang red cattle, highlighting breed-specific CNVRs, and transcriptome findings provide valuable insights into the underlying genetic characteristics of Pingliang red cattle. These results offer potential avenues for enhancing meat quality through a targeted breeding program. - Source: PubMed
Publication date: 2024/05/22
Wang YuanqingMa JunWang JingZhang LupeiXu LingyangChen YanZhu BoWang ZezhaoGao HuijiangLi JunyaGao Xue