Ask about this productRelated genes to: TYRO3 antibody
- Gene:
- TYRO3 NIH gene
- Name:
- TYRO3 protein tyrosine kinase
- Previous symbol:
- RSE
- Synonyms:
- Dtk, Brt, Tif, Sky, Etk-2, Rek
- Chromosome:
- 15q15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-02
- Date modifiied:
- 2016-10-05
Related products to: TYRO3 antibody
Related articles to: TYRO3 antibody
- Skin photoaging is a chronic inflammatory state induced by ultraviolet (UV) radiation. Ferroptosis has recently emerged as a critical mechanism implicated in the pathogenesis of photoaging. Ginsenosides, active compounds in ginseng, hold potential for treating skin photoaging, but their molecular mechanisms in regulating ferroptosis remain unclear. - Source: PubMed
Publication date: 2025/11/05
Tang LuluChen XianjieChen KeyueZheng XinleiYe MinLiu ZhongqiuLi WangLiu Xiaoyi - Tyro3, Axl, and Mer are receptor tyrosine kinases that comprise the TAM receptor family. These receptors, originally identified as orphan receptors, do not bind growth factors but rather ligands that can facilitate processes such as phagocytosis and dampening the innate inflammatory immune response. Enveloped viruses can hijack TAM receptors for viral entry through the fairly well-established mechanism of apoptotic mimicry. This mechanism involves 'tricking' the targeted host cell into endocytosing the virus through binding to exposed phosphatidylserine in the viral lipid bilayer envelope. While enveloped viruses utilize apoptotic mimicry for entry, it remains unclear how non-enveloped viruses enter the host cell through phosphatidylserine receptors such as TAM receptors. There is evidence that non-enveloped viruses can usurp host cell signaling pathways to cloak their particles in membranes, creating 'quasi-enveloped' viruses that enter the host through a sort of 'faux apoptotic mimicry.' These quasi-enveloped viruses can spread through non-lytic mechanisms to evade the host immune response and deliver virus particles to the targeted host cell. With the present review, we evaluate increasing evidence that TAM receptors may play a role in this process through their ability to indiscriminately bind phosphatidylserine in membranes, leading to the internalization of non-enveloped viruses packaged within phosphatidylserine-enriched extracellular vesicles. - Source: PubMed
Moran Steven JStarbird Chrystal A - Transarterial chemoembolization (TACE) is a key treatment for hepatocellular carcinoma (HCC). However, patient outcomes after TACE are heterogeneous, and robust prognostic biomarkers are needed. This study aimed to develop an efferocytosis-related prognostic signature to stratify HCC patients and others undergoing TACE treatment. - Source: PubMed
Publication date: 2026/05/07
Xie XiangpangZheng Bingru - TYRO3, AXL, and MERTK (TAM receptor tyrosine kinases) represent potential therapeutic targets in metastatic colorectal cancer. Pre-clinical and clinical data are needed to explore further how TAM receptors interact with the central nervous system, which could impact brain metastases from colorectal cancer (BM-CRC). - Source: PubMed
Noblanc AnaïsDkhissi FatimaGuichet Pierre-OlivierLebeau LucieMilin SergeEmambux SheikRoussille PaulineEvrard CamilleKarayan-Tapon LucieTougeron DavidBenzakour OmarRandrian Violaine - - Source: PubMed
Publication date: 2026/04/23
Tran Phuong ThaoShim Wan SeobJeong Won-CheolPark JaewooKim Myung JunOh SeungseokChoi Yong JuneChoi MunkyungPark MisoKang Keon Wook