Ask about this productRelated genes to: TTC32 antibody
- Gene:
- TTC32 NIH gene
- Name:
- tetratricopeptide repeat domain 32
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-11
- Date modifiied:
- 2014-11-19
Related products to: TTC32 antibody
Related articles to: TTC32 antibody
- TTC32-WDR35 gene cluster has been genome-wide significantly associated with coronary artery disease (CAD). However, the common variants in this region contributing to CAD risk remain elusive. - Source: PubMed
Publication date: 2020/10/02
Xu YingZhuo YangYe MengliangLi MengmengTang XiaojunZhou Li - Heat stress (HS) negatively affects chicken performance. Agricultural expansion will happen in regions that experience high ambient temperatures, where fast-growing commercial chickens are vulnerable. Indigenous chickens of such regions, due to generations of exposure to environmental challenges, might have higher thermal tolerance. In this study, two indigenous chicken ecotypes, from the hot and humid Mombasa (lowland) and the colder Naivasha (highland) regions, were used to investigate the effects of acute (5 h, 35°C) and chronic (3 days of 35°C for 8 h/day) HS on the cardiac and skeletal muscle, through RNA sequencing. The rectal temperature gain and the number of differentially expressed genes (DEGs) [False Discovery Rate (FDR) < 0.05] were two times higher in the acute stage than in the chronic stage in both ecotypes, suggesting that cyclic exposure to HS can lead to adaptation. A tissue- and stage-specific difference in response to HS was observed, with peroxisome proliferator-activated-receptor (PPAR) signaling and mitogen-activate protein kinase (MAPK) signaling pathways, enriched in heart and skeletal muscle, respectively, and the p53 pathway enriched only in the acute stage in both tissues. The acute and chronic stage DEGs were integrated by a region-specific gene coexpression network (GCN), and genes with the highest number of connections (hub genes) were identified. The hub genes in the lowland network were , , , , and , while , , , , and were the hub genes in the highland network. Pathway analysis of genes in the GCN showed that p53 and PPAR signaling pathways were enriched in both low and highland networks, while MAPK signaling and protein processing in endoplasmic reticulum were enriched only in the gene network of highland chickens. This shows that to dissipate the accumulated heat, to reduce heat induced apoptosis, and to promote DNA damage repair, the ecotypes activated or suppressed different genes, indicating the differences in thermal tolerance and HS response mechanisms between the ecotypes. This study provides information on the HS response of chickens, adapted to two different agro climatic environments, extending our understanding of the mechanisms of HS response and the effect of adaptation in counteracting HS. - Source: PubMed
Publication date: 2019/10/11
Srikanth KrishnamoorthyKumar HimansuPark WoncheoulByun MijeongLim DajeongKemp SteveTe Pas Marinus F WKim Jun-MoPark Jong-Eun - We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population. - Source: PubMed
Publication date: 2012/07/01
Lu XiangfengWang LaiyuanChen ShufengHe LinYang XueliShi YongyongCheng JingZhang LiangGu C CharlesHuang JianfengWu TangchunMa YitongLi JianxinCao JieChen JichunGe DongliangFan ZhongjieLi YingZhao LianchengLi HongfanZhou XiaoyangChen LanyingLiu DonghuaChen JingpingDuan XiufangHao YongchenWang LiguiLu FanghongLiu ZhendongYao CailiangShen ChongPu XiaodongYu LinFang XianghuaXu LihuaMu JianjunWu XianpingZheng RunpingWu NaqiongZhao QiLi YunLiu XiaoliWang MengqinYu DahaiHu DongshengJi XuGuo DongshuangSun DonglingWang QianqianYang YingLiu FangchaoMao QunxiaLiang XiaohuaJi JingfengChen PanpanMo XingboLi DianjiangChai GuopingTang YidaLi XiangdongDu ZhenhanLiu XuehuiDou ChenlongYang ZiliMeng QingjieWang DongWang RenpingYang JunSchunkert HeribertSamani Nilesh JKathiresan SekarReilly Muredach PErdmann Jeanette Peng XiaozhongWu XiguiLiu DepeiYang YuejinChen RunshengQiang BoqinGu Dongfeng