Ask about this productRelated genes to: TPMT antibody
- Gene:
- TPMT NIH gene
- Name:
- thiopurine S-methyltransferase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-08-25
- Date modifiied:
- 2019-04-23
Related products to: TPMT antibody
Related articles to: TPMT antibody
- Sarcopenia is a common complication in chronic liver disease (CLD) and is associated with increased morbidity and mortality. Tools like handgrip dynamometry (HGD) and transverse psoas muscle thickness (TPMT) have emerged for assessing sarcopenia, but comparative data on their prognostic performance are limited, especially in Indian populations. To compare the prognostic performance of HGD and TPMT in predicting 90-day morbidity (hospital stays, readmissions) and mortality in CLD patients; to validate sex-specific TPMT cutoffs for sarcopenia assessment in an Indian CLD cohort; and to examine the correlation of HGD and TPMT with the model for end-stage liver disease-sodium (MELD-Na) scores to enhance risk stratification and guide personalized interventions. - Source: PubMed
Publication date: 2026/07/27
Dave MayurSathawane AmolHajare SantoshKhobragade Harshal - Pharmacogenomics has the potential to improve the safety and efficacy of medicines in Saudi Arabia, and has a strong basis for implementation through population-specific genomic evidence, growing laboratory capacity and national digital health investment. We undertook a structured policy analysis and evidence synthesis of Saudi, regional, and international evidence; compared selected implementation capabilities across established models; and assessed national readiness descriptively across key health system domains. Using published evidence and structured expert judgement, we propose gene-drug priority tiers according to their clinical impact, population relevance and feasibility. Saudi Arabia's strengths are in genomic evidence and digital health infrastructure, but large gaps exist in governance, laboratory standardization, electronic health record interoperability, clinical decision support, workforce readiness, reimbursement, and outcome evaluation. Five pathways are proposed for initial implementation: -clopidogrel, -fluoropyrimidines, /-thiopurines, HLA-guided anticonvulsant prescribing and -abacavir. We propose a framework that could be supported by the Population Health Observatory and a six-phase roadmap, moving from governance and technical design to multicenter pilots, national scale-up and continuous evaluation. - Source: PubMed
Publication date: 2026/09/14
Alrubaie Kholud RAlzaylaee Raghad AAlayyaf Latifah AAlgahtani Farjah HAlomary Shaker AAssiri Abdullah MAlEissa Mariam M - Thiopurine drugs are used for the treatment of a wide variety of diseases ranging from autoimmune diseases to various leukemia types. As efficacy of thiopurine drugs is significantly reduced by Thiopurine S-methyltransferase (TPMT)-mediated S-methylation, accurate assessment of individual TPMT-activity levels is crucial for optimizing thiopurine drug dosage regimens for each patient. Given its multifaceted regulation, identifying occupational exposures impacting TPMT enzymatic activity is crucial. The influence of lead(Pb) on the enzymatic activity of TPMT was initially assessed in vitro, by spiking human blood having normal TPMT levels with increasing levels of Pb. The effect of occupational Pb-exposure on TPMT activity was further investigated by comparing blood TPMT activity levels of industrial workers prone to occupational Pb-exposure. Putative Pb-docking sites on TPMT enzyme were assessed through in silico analysis via MIB2 and CB-Dock2 servers. In vitro analysis indicated an inverse correlation between blood Pb-levels and TPMT-activity, which was further supported by in vivo analyses, providing evidence for Pb-mediated TPMT-inactivation. In silico Pb-docking analyses suggest two putative regions for Pb-mediated competitive TPMT-inhibition, four regions for direct/indirect inhibition, and four regions for allosteric inhibition. Further kinetic studies suggest that Pb exerts its inhibitory effect through competition with SAM for the active site. The observed inverse correlation between blood Pb and TPMT levels emphasizes the clinical importance of individualizing thiopurine drug dosage, especially for patients exposed to high levels of Pb. In vitro studies involving site-directed mutagenesis and analysis of patients with Pb-binding site mutations will validate the precise Pb-binding sites involved in TPMT-inhibition. - Source: PubMed
Publication date: 2026/09/10
Ceran Serdar CeyhanBi̇ngül EceUyar ArzuSerdar Muhittin A - Transdermal fentanyl (TDF) is widely used for moderate-to-severe cancer pain, yet substantial variability in fentanyl exposure, analgesic response, and tolerability remains incompletely explained by clinical factors. We evaluated whether pharmacogenetic variability is associated with pharmacokinetic parameters and clinical outcomes in cancer patients receiving TDF. - Source: PubMed
Publication date: 2026/08/17
Angelini LuciaAzzali IreneCarlini AndreaAndrisano VincenzaMontanari SerenaDall'agata MoniaSimonetti GiorgiaBochicchio Maria TeresaPaganelli MatteoValenti VanessaCravero PaolaCurrà MargheritaPetrini LindaDonati Costanza MariaMorganti Alessio GArdizzoni AndreaCorli Oscar EdoardoMaltoni Marco CesareRossi RominaRicci Marianna - Sarcopenia is common among patients with cirrhosis and is closely associated with poor prognosis. However, the value of different methods for assessing sarcopenia in predicting mortality risk in patients with cirrhosis remains controversial. This study aims to systematically evaluate the predictive ability of different methods for measuring sarcopenia regarding mortality risk in patients with cirrhosis. - Source: PubMed
Publication date: 2026/08/13
Xie WenruiShi WanxinXu RunbingShang ZimengHuo GuangyuanZhang ZheYang Zhiyun