Ask about this productRelated genes to: TOMM34 antibody
- Gene:
- TOMM34 NIH gene
- Name:
- translocase of outer mitochondrial membrane 34
- Previous symbol:
- -
- Synonyms:
- TOM34, HTOM34P
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-17
- Date modifiied:
- 2016-10-05
Related products to: TOMM34 antibody
Related articles to: TOMM34 antibody
- Polycystic ovary syndrome (PCOS) affects millions of women worldwide and is primarily known for its reproductive and hormonal symptoms. However, growing evidence suggests a strong link between PCOS and inflammation. Rheumatoid arthritis (RA) and osteoarthritis (OA) similarly involve systemic inflammation and immune dysregulation. Despite their distinct clinical manifestations, these disorders may share overlapping biological pathways. This study aimed to identify shared transcriptomic signatures between PCOS and autoimmune joint diseases such as RA and OA. - Source: PubMed
Publication date: 2025/12/17
Mavulati Sri ChandanaDodoala Sujatha - Recent studies have increasingly emphasized the poorer survival outcomes and reduced treatment responses associated with right-sided colon cancer (RCC). However, the underlying molecular mechanisms remain poorly understood. This study aimed to identify and characterize key biomarkers associated with progression and treatment response in patients with RCC. - Source: PubMed
Publication date: 2025/10/27
Hou YingdongXia HubinJi ChenghaoKong WenchengZhou YifengZhang Xiaofeng - The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as mitochondrial targeting signals. Presequences consistently form amphipathic helices, but they considerably differ with respect to their primary structure and length. Here we show that presequences can be classified into seven different groups based on their specific features. Using a test set of different presequences, we observed that group A presequences endow precursor proteins with improved in vitro import characteristics. We developed IQ-Compete (for Import and de-Quenching Competition assay), a novel assay based on fluorescence de-quenching, to monitor the import efficiencies of mitochondrial precursors in vivo. With this assay, we confirmed the increased import competence of group A presequences. Using mass spectrometry, we found that the presequence of the group A protein Oxa1 specifically recruits the tetratricopeptide repeat (TPR)-containing protein TOMM34 to the cytosolic precursor protein. TOMM34, and the structurally related yeast co-chaperone Cns1, apparently serve as presequence-specific targeting factors which increases the import efficiency of a specific subset of mitochondrial precursor proteins. Our results suggest that presequences contain a protein-specific priority code that encrypts the targeting mechanism of individual mitochondrial precursor proteins. - Source: PubMed
Publication date: 2025/07/21
Rödl SaskiaHoffman YasminJung FelixEgeler AnnikaNutz AnnikaŠimončík OliverJung MartinRäschle MarkusMuller PetrStorchová ZuzanaMühlhaus TimoHerrmann Johannes M - Circulating extracellular vesicles (EVs) can participate in innate repair processes triggered after intracerebral hemorrhage (ICH). We aimed to describe changes in the proteomic profile of circulating EVs between the acute and subacute phases of ICH and to compare the findings depending on outcomes, as an approach to unraveling such repair mechanisms. This was a prospective observational study including patients with non-traumatic supratentorial ICH. Exclusion criteria were previous disability, signs of herniation on baseline computed tomography, or limited life expectancy. EVs were isolated from blood samples at 24 h and 7 days after symptom onset. After 6-months' follow-up, patients were dichotomized into poor and good outcomes, defining good as an improvement of >10 points or > 50 % on the National Institutes of Health Stroke Scale and a modified Rankin Scale of 0-2. The protein cargo was analyzed by quantitative mass spectrometry and compared according to outcomes. Forty-four patients completed follow-up, 16 (35.5 %) having good outcomes. We identified 1321 proteins in EVs, 37 with differential abundance. In patients with good outcomes, proteins related to stress response (DERA, VNN2, TOMM34) and angiogenesis (RHG01) had increased abundance at 7 days. EVs from patients with poor outcomes showed higher levels of acute-phase reactants (CRP, SAA2) at 7 days compared with 24 h. In conclusion, the protein content of circulating EVs in patients with ICH changes over time, the changes varying depending on the clinical outcome, with greater abundance of proteins potentially involved in the repair processes of patients with good outcomes. - Source: PubMed
Publication date: 2024/09/12
Casado-Fernández LauraLaso-García FernandoPiniella DoloresGómez-de Frutos Mari CarmenOtero-Ortega LauraBravo Susana-BelénFuentes-Gimeno BlancaDocando FélixAlonso-López ElisaRuiz-Ares GerardoRodríguez-Pardo JorgeRigual Ricardode Celis-Ruiz ElenaHervás CarlosDíez-Tejedor ExuperioGutiérrez-Fernández MaríaAlonso de Leciñana María - Highly pathogenic respiratory RNA viruses such as SARS-CoV-2 and its associated syndrome COVID-19 pose a tremendous threat to the global public health. Innate immune responses to SARS-CoV-2 depend mainly upon the NF-κB-mediated inflammation. Identifying unknown host factors driving the NF-κB activation and inflammation is crucial for the development of immune intervention strategies. - Source: PubMed
Publication date: 2024/09/13
Shi QiwenZhang PengfeiHu QingtaoZhang TianxinHou RuixiaYin ShengxiangZou YilinChen FenghuaJiao ShuangSi LanlanZheng BangjinChen YichaoZhan TingzhuLiu YongxiangZhu WentingQi Nan