Ask about this productRelated genes to: TMPRSS5 antibody
- Gene:
- TMPRSS5 NIH gene
- Name:
- transmembrane serine protease 5
- Previous symbol:
- -
- Synonyms:
- MGC141886, MGC148044
- Chromosome:
- 11q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-05
- Date modifiied:
- 2018-01-19
Related products to: TMPRSS5 antibody
Related articles to: TMPRSS5 antibody
- Hypertensive intracerebral hemorrhage (ICH) is a devastating stroke subtype with high mortality and disability, yet reliable early risk biomarkers remain elusive. This study integrated protein microarray and transcriptomics with machine learning to identify a 4-gene panel (ADAM17, TMPRSS5, PLAU, and ADAMTS13). A LightGBM model with Nested Cross-Validation demonstrated robust discriminative power, achieving AUCs of 0.94 and 0.89 in independent validation cohorts for distinguishing ICH from hypertension and ischemic stroke, respectively. SHAP analysis identified PLAU as the most influential predictor, validated by RT-qPCR and ELISA in an independent replication cohort. Notably, prospective evaluation and animal models revealed a significant PLAU surge prior to vascular rupture. Functional inhibition of PLAU using UK122 significantly delayed ICH onset in hypertensive mice, independent of blood pressure. Furthermore, GSEA and immune infiltration analysis revealed specific enrichment of the Nod-like receptor signaling pathway and a uniquely proinflammatory microenvironment (activated dendritic cells and neutrophils) in ICH. - Source: PubMed
Publication date: 2026/05/30
Gao ZiyuLiu JingSun YingyingBai CongxiaYang HaitaoXu HaochenLi HaoSong LiSuo MiaomiaoChen Jingzhou - To explore associations between circulating proteomic pathways and structural, functional, and symptomatic measures of small- and large-fiber neuropathy and corneal immune activation in people with Type 2 diabetes (T2D). - Source: PubMed
Publication date: 2026/03/18
Ponirakis GeorgiosAl-Janahi IbrahimElgassim EinasDalloul Rajaa S DPetropoulos Ioannis NGad HodaKhan AdnanZaghloul Hadeel BAli HamdaSiddique Mashhood AMohamed Fatima F SAhmed Lina H MDakroury YoussraEl Shewehy Abeer M MSaeid RubaMahjoub FadwaAl-Noubi Muna NSarwath HinaPaul PradiptaKaul RidhimaSalivon IuliiaZirie Mahmoud AAl-Ansari YousufAtkin Stephen LSchmidt FrankMalik Rayaz A - Copy number variants (CNVs) are key drivers of human diversity and disease risk. Here we evaluate the role of CNVs across a broad range of human phenotypes and diseases by analysing CNVs from 470,727 UK Biobank whole-genome sequences and conducting a variant- and gene-level phenome-wide association study (PheWAS) with 2,941 plasma protein abundance measurements, 13,336 binary clinical phenotypes and 1,911 quantitative traits. Proteomic analyses validated functional associations of CNVs with nearby genes (cis-protein quantitative trait loci; cis-pQTLs)-with deletions and duplications typically associated with reduced and increased protein levels, respectively-and uncovered previously unknown protein-protein interactions (trans-pQTLs). Our PheWAS recapitulated known associations and uncovered associations in both coding and non-coding regions. Notably, we identified a rare deletion in ZNF451 associated with increased leukocyte telomere length and a non-coding deletion of a SLC2A9 enhancer associated with reduced gout risk. In addition, by combining CNVs with protein-coding single nucleotide variants and indels, we enhanced the power of our study to detect gene-disease associations. Finally, we leveraged this multiomics dataset to identify several pQTLs that constitute candidate biomarkers, including TMPRSS5 for Charcot-Marie-Tooth disease type 1A. This multiancestry whole-genome-sequence CNV PheWAS offers insights into the roles of CNVs in human health outcomes and could serve as a valuable resource for therapeutic development. - Source: PubMed
Publication date: 2026/02/04
Zou Xueqing ZoeHu FengyuanLou HaiyiBurren Oliver SLi XiaoyinMegy KarynWheeler EleanorWu QiangAtanur Santosh SKarpinski MarcinLoesch DouglasFairhurst-Hunter ZammyDeevi Sri V VOerton ErinWen SeanJiang XiaoSalvoro CeciliaMitchell JonathanNag AbhishekHollis BenO'Neill Amanda Harrow JenMacArthur StewartWasilewski SebastianO'Dell SeanTian LifengSmith Katherine RDel Angel GuillermoFabre MargareteDhindsa Ryan SWang QuanliPetrovski SlavéCarss Keren - Analyses of genomic and proteomics data in prospective biobank studies in diverse populations may discover novel or repurposing drug targets for stroke. - Source: PubMed
Publication date: 2025/04/30
Yao PangMazidi MohsenPozarickij AlfredIona AndriWright NeilLin KuangMillwood Iona YFry HannahKartsonaki ChristianaChen YipingYang LingDu HuaidongAvery DanielSchmidt-Valle DanSun DianjianyiPei PeiLv JunYu CanqingHill MichaelBennett Derrick AWalters Robin GLi LimingClarke RobertChen Zhengming - Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma proteins on stroke outcomes in a two-sample Mendelian randomization framework and assess mediation effects by stroke risk factors. We find associations between genetically predicted plasma levels of six proteins and stroke (P ≤ 1.62 × 10). The genetic associations with stroke colocalize (Posterior Probability >0.7) with the genetic associations of four proteins (TFPI, TMPRSS5, CD6, CD40). Mendelian randomization supports atrial fibrillation, body mass index, smoking, blood pressure, white matter hyperintensities and type 2 diabetes as stroke risk factors (P ≤ 0.0071). Body mass index, white matter hyperintensity and atrial fibrillation appear to mediate the TFPI, IL6RA, TMPRSS5 associations with stroke. Furthermore, thirty-six proteins are associated with one or more of these risk factors using Mendelian randomization. Our results highlight causal pathways and potential therapeutic targets for stroke. - Source: PubMed
Publication date: 2022/10/17
Chen LingyanPeters James EPrins BramPersyn ElodieTraylor MatthewSurendran PraveenKarthikeyan SavitaYonova-Doing EkaterinaDi Angelantonio EmanueleRoberts David JWatkins Nicholas AOuwehand Willem HDanesh JohnLewis Cathryn MBronson Paola GMarkus Hugh SBurgess StephenButterworth Adam SHowson Joanna M M