Ask about this productRelated genes to: TMEM100 antibody
- Gene:
- TMEM100 NIH gene
- Name:
- transmembrane protein 100
- Previous symbol:
- -
- Synonyms:
- FLJ10970, FLJ37856
- Chromosome:
- 17q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-16
- Date modifiied:
- 2015-03-02
Related products to: TMEM100 antibody
Related articles to: TMEM100 antibody
- This study explores the transcriptomic, mutational, and immunogenic characteristics linked to significantly differentially expressed genes (DEGs) in colorectal (COAD), liver (LIHC), lung (LUAD), gastric (STAD), and breast (BRCA) cancers. Applying integrated bioinformatics algorithms, we discovered common upregulated and downregulated hub genes and assessed their prognostic importance, genomic modifications, copy number variations, functional enrichment, and pathway engagement. The persistent overexpression of ANLN and CTHRC1 in five cancer types, along with poor survival outcomes, underscores their suitability for multi-epitope vaccine development, emphasizing their antigenic potential and significance as universal therapeutic targets. Five genes-ABCA8, PDK4, MT1M, TMEM100, and LIFR-exhibited consistent downregulation and demonstrated tumor-suppressive characteristics. Genomic analyses demonstrated elevated mutation frequencies in ABCA8 and LIFR, predominantly C>T transitions that suggest age-related mutational signatures. Copy number alterations confirmed oncogenic amplifications (ANLN and CTHRC1) and tumor suppressor deletions (e.g., ABCA8). Functional enrichment associated differentially expressed genes with mitosis, chromosome segregation, and metabolic pathways. A multi-epitope vaccine targeting ANLN and CTHRC1 has been established leveraging predicted B-cell and T-cell epitopes, β-defensin as an adjuvant, and efficient linkers. Structural validation indicated desirable folding, stability, and solubility. The vaccine exhibited significant MHC binding, accomplishing 99% global population coverage, alongside strong immune simulation findings. Codon optimization and subsequent cloning into the pET28a(+) vector confirmed the preparation for bacterial expression. ANLN and CTHRC1 demonstrate significant targets for universal immunotherapy. The multi-epitope vaccine demonstrates significant efficacy in silico and has the potential to be widely employed as a cancer immunotherapeutic. - Source: PubMed
Publication date: 2026/04/19
Roy Suronjit KumarHasan RubaitBiswas Mohammad ShahangirPodder Munna KumarMoin Abu TayabPatil Rajesh B - Chronic pain remains a pervasive and debilitating condition with few effective treatments available. Emerging evidence reveals that transmembrane (TMEM) proteins are not merely passive structural elements but dynamic regulators of nociceptive signaling. Key TMEM family members, including TMEM100, TMEM16A/F, TMEM175, TMEM97, TMEM120A/TACAN, and TMEM233, orchestrate pain transmission by modulating ion channels, inflammatory mediators, and intracellular signaling cascades across peripheral and central pathways. Decoding their structural and functional diversity reveals new opportunities to design targeted analgesics that disrupt pathological pain at its source while sparing central nervous system side effects. By harnessing the therapeutic potential of TMEM proteins, we may redefine strategies for managing chronic and treatment-resistant pain, ultimately improving outcomes for millions affected worldwide. - Source: PubMed
Publication date: 2026/04/10
Kappara DeepikaVerma NiveditaTiwari Vinod - Lung cancer is the leading cause of global cancer mortality, with treatment efficacy limited by high heterogeneity, drug resistance, and an immunosuppressive tumor microenvironment. Focusing primarily on non-small cell lung cancer (NSCLC), this review systematically analyzes eight key regulated cell death (RCD) pathways in lung cancer. These pathways are apoptosis, autophagy, necroptosis, ferroptosis, cuproptosis, pyroptosis, immunogenic cell death (ICD), and lysosome-dependent cell death (LDCD). Mechanistic dissection reveals complex crosstalk and a dynamic equilibrium among these pathways. For instance, apoptosis escape via EGFR/PI3K/Akt/mTOR signaling promotes survival, while autophagy exhibits a context-dependent dual role regulated by factors such as RBBP4 and the AURKA-CXCL5 axis. Importantly, several RCD pathways exert potent immunomodulatory functions. Necroptosis activates T cells by releasing damage-associated molecular patterns (DAMPs), while ferroptosis enhances NK cell cytotoxicity through GPX4 inactivation. Regarding therapeutic advances, synergistic strategies show promise, such as berberine with EGFR-TKIs inducing apoptosis via EGFR degradation, and (-)-Guaiol triggering ICD to synergize with PD-1/PD-L1 inhibitors. Novel inducers, including Auranofin (ferroptosis), TMEM100 agonists (necroptosis), and cuproptosis nanomedicines (e.g., DE-CuO NPs), demonstrate preclinical potential. Prognostic models based on RCD-related genes (e.g., LDCD signatures) can predict immune features and response to immune checkpoint inhibitors (ICIs). However, clinical translation faces bottlenecks, including intricate pathway crosstalk, difficulties in remodeling the immunosuppressive niche, low ICI response in EGFR-mutant patients, and a lack of standardized biomarkers and optimized delivery systems. Future research should prioritize coordinated targeting of multiple death pathways, utilize advanced computational tools integrated with multi-omics data to decipher RCD network complexity and optimize treatment prediction, and strengthen interdisciplinary translational efforts. Ultimately, a deep understanding of the RCD network paves the way for a paradigm shift toward precision therapy in lung cancer. - Source: PubMed
Publication date: 2026/02/18
Xue FangsuSun JiachengZhang JitaiShen Yuntian - Endothelial cells within chronic pulmonary artery thrombi in CTEPH overexpress transmembrane protein 100 (TMEM100), an activin A receptor-like kinase 1 (ACVRL1 or ALK1) signaling-dependent gene, and TGFβ1 upregulated TMEM100 transcription in healthy lung ECs. TMEM100 permitted the TGFβ1-induced increase of ALK1, while repressing ALK5, and preventing ALK1-TMEM100 signaling impaired angiogenesis ex vivo. Our data indicate that TGFβ1-ALK1-TMEM100 signaling is active during CTEPH thrombus revascularization. - Source: PubMed
Publication date: 2026/01/28
Bochenek Magdalena LGhasemi ImanWiedenroth Christoph BBikou OlympiaKarampinis IoannisRoessner Eric DHobohm LukasGuth StefanLurz PhilippKonstantinides StavrosSchäfer Katrin - Fish eggs are of pivotal significance in the domain of fish reproduction, and the degree of their development exerts a profound effect on reproductive capacity. Spotted scat (Scatophagus argus) is an important economic mariculture fish in East and Southeast Asia. Previous research has focused on how pituitary hormones are expressed and released during ovarian development. However, few studies have examined how the pituitary gland controls the expression of hormone genes during the development of the ovaries. In this study, the focus was on the analysis of the transcriptome profiles of pituitary glands in spotted scat. The analysis was conducted on female specimens with ovaries in two distinct states: before yolk formation (BYF) and after yolk formation (AYF). The results reveal that 149 differentially expressed genes (DEGs) were identified between BYF and AYF. Compared to the BYF stage, 85 genes were found to be up-regulated, while 64 genes were down-regulated in the AYF. Notably, some genes' expression level has alteration. Such as hormone receptors (gnrhr2 and ar), promote ovarian development genes (cga, cgba, fshb, lhb), estrogen synthase and regulated genes (cyp19a1, hdac9b, and gadd45b), hormone regulation (fgfr4). Additionally, changes have been observed in nociceptive inhibitory and appetite-related genes (e.g. tmem100 and reln). GO and KEGG enrichment analysis revealed that the PI3K-AKT signaling pathway is implicated in the regulation of pituitary hormones. The transcriptomic data provide valuable insights for further study of the regulatory role of the pituitary gland in the ovarian development of spotted scat and provide data support for better artificial regulation of ovarian development and egg maturation in captive breeding of spotted scat. - Source: PubMed
Publication date: 2025/07/05
Liu ZhilongLiu PengWan YeshengWang TuoJiang DongnengTian ChangxuChen HuapuJiang MouyanDeng SipingWu TianliZhu Chun HuaHong YucongLi Guangli