Ask about this productRelated genes to: TCP11L2 antibody
- Gene:
- TCP11L2 NIH gene
- Name:
- t-complex 11 like 2
- Previous symbol:
- -
- Synonyms:
- MGC40368
- Chromosome:
- 12q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-04
- Date modifiied:
- 2016-03-14
Related products to: TCP11L2 antibody
Related articles to: TCP11L2 antibody
- Sepsis is a life-threatening disease with high mortality and one of the leading causes of death worldwide. Although studies have shown that ubiquitylation is closely related to the occurrence and development of sepsis, the prognostic and diagnostic value of ubiquitylation-related genes in sepsis remains unclear. In this study, we obtained sepsis datasets from the Gene Expression Omnibus (GEO) database and identified ubiquitylation-related genes from the Ubiquitin and Ubiquitin-like Conjugation Database (iUUCD). We identified 159 differentially expressed genes related to ubiquitylation between sepsis patients and healthy individuals, and the prognosis of sepsis subgroups distinguished by these ubiquitylation genes showed significant differences, demonstrating the importance of the ubiquitylation phenotype in sepsis. To explore the prognostic value of ubiquitination-related genes in sepsis, we constructed a ubiquitylation-related score (URS) through LASSO analysis, random forest, and Cox regression analysis. Importantly, we validated the reliability of this model in both the GEO database cohort and the external cohort data from our unit. Finally, we identified LTB and TCP11L2 as key ubiquitylation-related genes, explored their expression patterns and potential biological context through single-cell RNA sequence analysis, and validated their expression and diagnostic value using patient blood samples. Our study suggests a link between ubiquitylation and sepsis, which can be used as a potential biomarker to guide the diagnosis, treatment, and prognosis of sepsis and proposes new ideas for future clinical research. - Source: PubMed
Publication date: 2026/02/17
Xue HaiyanChen LiheZhao XiujuanZhu Fengxue - Sepsis remains a critical global health threat characterized by high mortality and complex immune-metabolic dysregulation. This study identifies ferritinophagy-related prognostic genes (FRGs) that are causally linked to sepsis outcomes using a multi-omics approach integrating bulk and single-cell transcriptomics with Mendelian randomization. Among 1047 candidate genes, UBE2Q1, NEDD4L, and TCP11L2 were selected to build a risk model that effectively stratified sepsis patients and predicted mortality. Functional enrichment analysis revealed associations with oxidative phosphorylation, ribosome function, and Parkinson's disease pathways. Immune infiltration analysis identified increased γδ T and NK cell levels in high-risk patients, with significant correlations to prognostic genes. Single-cell RNA sequencing further revealed dynamic gene expression shifts across key immune cell types including T cells, monocytes, and platelets. Cell-cell communication and pseudo-time analyses highlighted the roles of UBE2Q1 and NEDD4L in immune regulation and development. This study provides preliminary clues that ferritin and autophagy-related genes may be involved in the pathogenesis of sepsis, and proposes potential molecular targets that can be used for prognostic evaluation and therapeutic intervention. - Source: PubMed
Publication date: 2025/12/08
Xiong WeichuanLiu Fangpeng - Lung adenocarcinoma (LUAD) shows high recurrence rate and poor prognosis. Genes associated with ubiquitin play a role in the onset and advancement of cancers; however, they have yet to be employed for the diagnosis and prognosis of LUAD. - Source: PubMed
Publication date: 2025/08/15
Li YueTian WeiChen ChenLiu HailinZhang ZhenfaWang Changli - Trionyx sinensis Hemorrhagic Syndrome Virus (TSHSV), the first aquatic arterivirus identified in China, causes severe mortality to T. sinensis. In this study, we sought to determine the functions of T. sinensis mRNAs and non-coding RNAs (ncRNAs) that were differentially expressed (DE) over different periods of TSHSV infection of T. sinensis lung. We used RT-qPCR to validate the sequencing results of select RNAs, confirming their reliable and referable nature. Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were used to predict multiple biological functions and signaling pathways in various comparison groups (1-day versus mock, 3-day versus 1-day, and 5-day versus 3-day). Multiple types of differentially expressed RNA, including mRNA, lncRNA, circRNA, and miRNA, were associated with cardiac dysfunction, coagulation abnormalities, and arachidonic acid metabolism at day 1. Pre-inflammatory cytokines and inflammatory factors such as PLA2G4A, cPLA2, γ-GGT1, TNFRSF14, TCP11L2, PTER CYP2J2 and LTC4S, were noticeably regulated at the same time. On day 3, multiple GO terms and KEGG pathways were implicated, including those related to virus defense, apoptosis, pyroptosis, and inflammatory response. Notably, key genes such as RSAD2, TRIM39, STAT4, CASP1, CASP14, MYD88, CXCL3, CARD11, ZBP1, and ROBO4 exhibited significant regulation. The lncRNAs and circRNAs that targeted the genes involved in viral recognition (TLR5), apoptosis (CARD11), pyroptosis (ZBP1), inflammatory processes (NEK7, RASGRP4, and SELE) and angiogenesis (ROBO4) exhibited significant regulation. Significantly regulated miRNAs were primarily linked to genes involved in apoptosis (Let-7f-3p, miR-1260a, miR-455-3p), and inflammation (miR-146a, miR-125a, miR-17a, miR-301b, and miR-30a-3p). The findings could advance our understanding of the host immunological response to TSHSV and offer new ideas for developing effective strategies to prevent infection of T. sinensis. - Source: PubMed
Publication date: 2023/11/20
Lyu SunjianGuo QiShen WeifengHan MingmingXiong FuleiDai XiaolingLiu LiBu WeishaoLou BaoYuan Julin - T-complex 11 like 2 (TCP11L2) is a protein containing a serine-rich region in its N-terminal region. However, the function of TCP11L2 is unclear. Here, we showed that TCP11L2 expression gradually increased during muscle-derived satellite cell (MDSC) differentiation in vitro, reaching a peak on Day 3, which is the migration and fusion stage of MDSCs. Using CRISPR/dCas9 gene-editing technology to elevate or repress the expression of TCP11L2, we also showed that TCP11L2 promoted MDSC differentiation. Moreover, wound-healing assays showed that TCP11L2 promoted the migration of MDSCs during differentiation. Additionally, immunofluorescence analyses showed that TCP11L2 was mainly distributed around the microfilament and microtubules. Furthermore, the expression of TCP11L2 affected the expression of actin-related protein 2/3 (ARP2/3) complex. Co-immunoprecipitation assays and immunofluorescence analysis showed that TCP11L2 interacted with formin-like 2 (FMNL2). This protein promoted migration of bovine MDSCs by affecting the expression of ARP2/3. Finally, the activities of TCP11L2 during MDSC differentiation and migration were blocked when FMNL2 was inhibited. Taken together, our data established that TCP11L2 interacted with FMNL2 to promote MDSC migration and differentiation. - Source: PubMed
Publication date: 2020/02/04
Li ShuangWang ZhiqiTong HuiliLi ShufengYan Yunqin