Ask about this productRelated genes to: SYNJ2BP antibody
- Gene:
- SYNJ2BP NIH gene
- Name:
- synaptojanin 2 binding protein
- Previous symbol:
- -
- Synonyms:
- Arip2
- Chromosome:
- 14q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-19
- Date modifiied:
- 2013-05-10
Related products to: SYNJ2BP antibody
Related articles to: SYNJ2BP antibody
- Depression is a neuro-psychiatric disorder that seriously impairs human physical and mental health. Its clinical treatment effect is not satisfactory and the pathogenesis is unclear. Therefore, it is urgent to clarify its pathological mechanism to provide a new direction for the treatment of depression. The "pathological triad", comprising oxidative stress (an imbalance between reactive oxygen species and antioxidant defenses), neuroinflammation (inflammatory responses within the central nervous system), and apoptosis (programmed cell death), has emerged as a central mechanistic driver underlying the pathophysiology of depression. The present study found that chronic unpredictable mild stress (CUMS) drives a significant down-regulation of the synaptojanin-2-binding protein (SYNJ2BP) expression in hippocampal CA1 subregion. Overexpression of SYNJ2BP mitigates oxidative stress, neuroinflammation, neuronal apoptosis and synaptic structural impairment, while concurrently ameliorating depressive- and anxiety-like phenotypes by interacting with SYNJ2 to modulate phosphatidylinositol 4,5-bisphosphate (PIP)/inositol 1,4,5-trisphosphate (IP) metabolism, and subsequently suppress downstream p38/JNK signaling cascades. Conversely, SYNJ2BP knockdown or exogenous PIP administration abrogates these protective effects, whereas inhibition of IP signaling recapitulates the beneficial outcomes of SYNJ2BP overexpression. Collectively, our findings reveal a new SYNJ2BP/SYNJ2/PIP/IP signaling axis in neurons of hippocampal CA1 subregion that critically mediates CUMS-induced neuronal damage and emotional behavioral deficits, thereby potentially providing therapeutic targets for depression treatment. - Source: PubMed
Publication date: 2026/04/07
Wang WenjingChen XiaoLi YeWang ChangminChang MengniGuo RuojingWei PenghuiXu ZhipengYu Shuyan - The import of most mitochondrial proteins requires that their precursor proteins be bound by the peripheral receptor proteins TOM20, TOM22, and TOM70. Budding yeast TOM20 and TOM70 have been extensively studied regarding their interaction partners and recognized substrates; however, little data is available for metazoan cells. Using APEX2-based proximity labeling, we created association profiles for human TOMM20 and TOMM70 in HeLa cells. We focused particularly on their interactions with RNA-binding proteins (RBPs) because there is evidence of RNA association with the mitochondrial outer membrane (MOM) and of local translation at the mitochondrial surface, however, these processes are poorly understood. Our results demonstrate that several RBPs and translation factors preferentially associate with TOMM20 rather than TOMM70. These include SYNJ2BP, a previously identified membrane-bound RBP that binds and protects mRNA encoding mitochondrial proteins. Inhibiting translation with puromycin increased the association of these RBPs with TOMM20 compared to TOMM70. This suggests that TOMM20, but not TOMM70, may play a role in maintaining cellular homeostasis during translation stress by retaining protective RBPs and translation-related proteins at the MOM. - Source: PubMed
Publication date: 2025/12/22
Akram SairaZittlau Katharina ISharma KaranFitzgerald Julia CRafiq NishaMaček BorisJansen Ralf-Peter - Alzheimer's disease (AD) represents the most prevalent neurodegenerative disorder, with mitochondrial dysfunction being observed in both AD patients and mouse models. Nonetheless, further investigation is required to elucidate the pathogenic genes associated with AD and to develop early diagnostic methodologies centered on mitochondrial function. - Source: PubMed
Publication date: 2025/11/27
Zhu XuchaoZhang LingQin Chuan - Clear cell renal cell carcinoma (ccRCC), the most prevalent form of kidney cancer, often presents or recurs as an advanced, aggressive, and lethal disease. Thus, biomarkers are needed to identify patients at risk of developing advanced-stage or treatment-resistant ccRCC. SYNJ2BP, a cytoplasmic scaffolding protein, regulates ACVR2 activity, a key mediator of signaling pathways involved in tumor progression and metastasis. This study aimed to ascertain if , a gene highly expressed in normal kidney tissue, may serve as a predictive biomarker for ccRCC. - Source: PubMed
Saulsbury Marilyn DHeyliger Simone OTaioli EmanuelaTurley Tamiel NReynolds Jordan PCopland John AKase Adam MReams R Renee - Alzheimer's disease (AD) represents the most common neurodegenerative disorder, characterized by progressive cognitive decline and memory loss. Despite the recognition of mitochondrial dysfunction as a critical factor in the pathogenesis of AD, the specific molecular mechanisms remain largely undefined. - Source: PubMed
Zhang KuoYang KaiYu GongchangShi Bin