Ask about this productRelated genes to: STAT4 antibody
- Gene:
- STAT4 NIH gene
- Name:
- signal transducer and activator of transcription 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q32.2-q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-08
- Date modifiied:
- 2018-02-13
Related products to: STAT4 antibody
Related articles to: STAT4 antibody
- Social stress is a risk factor for psychiatric disorders and also influences immune function. While it is known that acute social stress impacts the number of immune cells in circulation, the temporal dynamics of stress induced immune-related transcriptional changes in human blood remain unclear. To investigate changes in gene expression, we exposed 27 adults to the Trier Social Stress Test (TSST), and collected blood at baseline, as well as 5, 30, 60 and 90 min after stress. Whole-blood gene expression was profiled using a 5' targeted RNA-sequencing method (STRT). Differential expression was analyzed using linear and cubic models. We observed a total of 54 differentially expressed genes following stress. Fast responses, with a transient peak immediately following stress, were enriched for cytotoxic T-cell, NK-cell and dendritic cell functions (e.g., and ) and paralleled lymphocyte count changes. In contrast, gradual, linear responses without any evident peak were enriched for neutrophil related genes (e.g., , and ) and did not mirror neutrophil counts, indicating cell intrinsic transcriptional changes. From pathway and transcription factor enrichment analyses the IL-12 family mediated signaling is inferred as a mechanism linking stress to immune gene regulation. Our results showed both fast and slower changes in gene expression in different immune cell populations following acute psychosocial stress. The involvement of the IL-12-STAT4 axis and genes such as and suggests molecular mechanisms through which stress-related immune activation may contribute to vulnerability for anxiety and depressive disorders. - Source: PubMed
Publication date: 2026/09/17
Grönvall HampusAbdelhalim SylviaTabrizi FaraEzer SiniYazgeldi Gunaydin GamzeArner ErikRosén JörgenKatayama ShintaroKere JuhaÅhs FredrikMikkola Lea - Heart failure (HF) and non-obstructive azoospermia (NOA) are high-burden diseases that share chronic inflammation and tissue injury. Macrophages are key regulators in both conditions, yet whether a common molecular basis exists remains unclear. - Source: PubMed
Publication date: 2026/09/15
Zhao ZhengLi RongLi KaiZhang RuiTian JiaweiTeng DaZhou XiaoyanJia BaoqiYuan XianmiaoXin Hui - Activation of the tumor immune microenvironment (TIME) is crucial for controlling nasopharyngeal carcinoma (NPC) progression. This study aims to identify miPEP133 as novel therapeutic targets for NPC treatment. - Source: PubMed
Publication date: 2026/08/11
Zhu MingjingZhang HuisiLiang DingHuang FanWu LanhuaCao ZuotingChen SixiaKang Min - Asthma is a heterogeneous chronic inflammatory syndrome, with the T2-high endotype defined by robust type 2 immune responses and skewed T helper polarization. Although H3K9 acetylation (H3K9ac) is a key activating histone mark in T helper differentiation, its genome-wide promoter landscape in circulating immune cells of T2-high asthma remains uncharacterized. - Source: PubMed
Publication date: 2026/09/16
González DanielInfante AlexLópez-Kleine LilianaCeschin DaniloFernández-Sánchez María JoséCañas-Arboleda AlejandraZafra-Mejía CarlosRojas Adriana - Rheumatoid arthritis (RA) is a chronic autoimmune disease in which distinct macrophage (MΦ) endotypes can guide therapy. TLR5, upregulated during disease flares, drives an IL-1βNFKB1IFN-γSTAT4 MΦ phenotype in blood and synovium that is refractory to tumour necrosis factor (TNF) and IL-6R blockade. This study aimed to identify an alternative strategy to correct inflammation and metabolic dysfunction in these pathogenic MΦs. - Source: PubMed
Publication date: 2026/09/04
Zack Stephanie RSatoeya NehaSosa Hernández Víctor AndrésDeen SaniaNijim WesZanotti BrianVolin Michael VBurgos AdelKaram Joseph AXia YinglinUmali Diana CArami ShivaJetanalin PimFriedman MiriamO'Neill Luke A JWeyand Cornelia MSweiss NaderaShahrara Shiva