Ask about this productRelated genes to: STAT4 antibody
- Gene:
- STAT4 NIH gene
- Name:
- signal transducer and activator of transcription 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q32.2-q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-08
- Date modifiied:
- 2018-02-13
Related products to: STAT4 antibody
Related articles to: STAT4 antibody
- Activation of the tumor immune microenvironment (TIME) is crucial for controlling nasopharyngeal carcinoma (NPC) progression. This study aims to identify miPEP133 as novel therapeutic targets for NPC treatment. - Source: PubMed
Publication date: 2026/08/11
Zhu MingjingZhang HuisiLiang DingHuang FanWu LanhuaCao ZuotingChen SixiaKang Min - Asthma is a heterogeneous chronic inflammatory syndrome, with the T2-high endotype defined by robust type 2 immune responses and skewed T helper polarization. Although H3K9 acetylation (H3K9ac) is a key activating histone mark in T helper differentiation, its genome-wide promoter landscape in circulating immune cells of T2-high asthma remains uncharacterized. - Source: PubMed
Publication date: 2026/09/16
González DanielInfante AlexLópez-Kleine LilianaCeschin DaniloFernández-Sánchez María JoséCañas-Arboleda AlejandraZafra-Mejía CarlosRojas Adriana - Rheumatoid arthritis (RA) is a chronic autoimmune disease in which distinct macrophage (MΦ) endotypes can guide therapy. TLR5, upregulated during disease flares, drives an IL-1βNFKB1IFN-γSTAT4 MΦ phenotype in blood and synovium that is refractory to tumour necrosis factor (TNF) and IL-6R blockade. This study aimed to identify an alternative strategy to correct inflammation and metabolic dysfunction in these pathogenic MΦs. - Source: PubMed
Publication date: 2026/09/04
Zack Stephanie RSatoeya NehaSosa Hernández Víctor AndrésDeen SaniaNijim WesZanotti BrianVolin Michael VBurgos AdelKaram Joseph AXia YinglinUmali Diana CArami ShivaJetanalin PimFriedman MiriamO'Neill Luke A JWeyand Cornelia MSweiss NaderaShahrara Shiva - Type I immunity, mediated by IFN-γ, is essential for combating intracellular pathogens but also drives inflammatory diseases. How the immune system balances protective type I responses with pathological inflammation is elusive. While the IL-12-STAT4 pathway that promotes IFN-γ production is well-established, the intrinsic negative regulators remain unclear. We establish that RASA3 serves as a permissive checkpoint for type I immune responses. T cell-specific ablation of RASA3 amplified Th1/Tc1 immunity and IFN-γ expression, enhancing the clearance of Listeria monocytogenes but exacerbating allergic contact dermatitis. We further identify the hematopoietic cell kinase (HCK) as a direct kinase for STAT4, which binds to and phosphorylates it at the Tyr693 residue to elicit IFN-γ production. Mechanistically, RASA3 represses the translation of HCK via constraining ribosomal protein RPL36A expression. Additionally, the RASA3-HCK axis is conserved in human Th1 cells. Thus, we define a critical role of the RASA3-HCK-STAT4 axis in fine-tuning type I immunity and offer promising targets for intervening in Th1/Tc1-driven pathologies. - Source: PubMed
Publication date: 2026/08/05
Song JiayuLiu XiaoyuSun JieCheng XiHe ChuanZhong YunhongZhang JinfangZhang JunjieXiong HuiWu Bing - The prevalence of food allergy has been rising over the past decade, but effective treatments remain limited. The purpose of this study was to investigate the effect of ginkgolide B (GB), a natural bioactive compound with well-documented anti-inflammatory and immunoregulatory properties, on a mouse model of food allergy and to elucidate the mechanism mediated by the mTOR signaling pathway. - Source: PubMed
Publication date: 2026/08/18
Zhou RongqinYang XiaotongTan PanpanWang HuanZeng DanMa Xiaojuan