Ask about this productRelated genes to: SOX17 antibody
- Gene:
- SOX17 NIH gene
- Name:
- SRY-box 17
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2015-11-23
Related products to: SOX17 antibody
Related articles to: SOX17 antibody
- Extraembryonic lineages, specifically the trophectoderm (TE) and primitive endoderm (PrE), are indispensable for early embryogenesis and successful pregnancy. Expanded potential stem cells (EPSCs) can contribute to both embryonic and extraembryonic fates, providing a platform to model early lineage specification. - Source: PubMed
Publication date: 2026/09/09
Kim HaneulCai LianHyun Sang-HwanKim Eunhye - BackgroundMalignant serous effusions may be the first manifestation of an underlying malignancy, and accurate primary-site attribution is essential. However, distinguishing Müllerian carcinoma, breast carcinoma, and mesothelioma in effusion cytology remains a challenge because of overlapping immunophenotypes. We evaluated SOX17 and TRPS1 in this setting.Materials and MethodsA multicenter retrospective cohort including 650 tissue specimens (300 breast carcinomas, 300 Müllerian tumors, and 50 mesothelial lesions) and 150 malignant serous effusion cell blocks was analyzed. SOX17 and TRPS1 expression was assessed by immunohistochemistry and compared with established markers, including PAX8, GATA3, WT1, and calretinin. Sensitivity, specificity, and positive predictive value (PPV) were calculated according to the primary diagnosis.ResultsIn the tissue cohort, SOX17 showed 87% sensitivity and 100% specificity for Müllerian tumors, with no expression in breast carcinomas or mesothelial lesions, including tumors with PAX8/WT1 co-expression. This specificity was retained in cell blocks, yielding a PPV of 100%. TRPS1 showed 98% sensitivity for breast carcinoma and identified 84% of GATA3-negative breast carcinomas. However, TRPS1 expression was also observed in 48% of tubo-ovarian serous carcinomas, limiting its PPV for breast carcinoma in effusions to 55% despite a negative predictive value of 97%.ConclusionSOX17 is a highly specific confirmatory marker for Müllerian origin and may help resolve diagnostic pitfalls related to PAX8-positive mesothelial lesions. TRPS1 is a complementary marker for breast carcinoma, including GATA3-negative tumors, but its stand-alone diagnostic value is limited by cross-reactivity in Müllerian serous carcinomas. These findings support a panel-based approach for accurate primary-site attribution in malignant serous effusions. - Source: PubMed
Publication date: 2026/09/19
Issin GizemDemir FatihYaylı EsraÇağatay Diren VuslatYılmaz İsmailGirgin Rabia BurçinGamsızkan MehmetZemheri EbruŞimşek Hasan AktuğSayar İlyasTaşkın Türkmenoğlu Tuğba - In birds, sperm storage tubules (SSTs) located at the uterovaginal junction (UVJ) facilitate long-term sperm storage and regulate sperm release in coordination with ovulation. In Japanese quail (Coturnix japonica), sperm release from SSTs might be mediated by membrane progestin receptor α (mPRα), encoded by the progestin and adipoQ receptor family member 7 (PAQR7) gene. Although PAQR7 plays an important role in reproductive functions, the mechanisms regulating its transcription remain unclear. Therefore, in this study, we investigated the transcriptional regulatory mechanisms of PAQR7 in Japanese quail SSTs. Reporter assays using serial deletion constructs identified multiple positive and negative regulatory regions within the 5' upstream region of PAQR7. Analysis of the proximal promoter region revealed a putative initiator element and non-canonical promoter structure. Electrophoretic mobility shift assays identified several nuclear protein-binding regions within the upstream regulatory region. Candidate transcription factors potentially binding to these regions were predicted using JASPAR and RNA-Seq transcriptome data. Quantitative PCR further revealed that FOS, JUN, FOXN1, and SOX17 levels were significantly upregulated in SST-containing tissues compared to those in non-SST epithelial tissues. Overall, our findings suggest that PAQR7 expression in SSTs is regulated by an SST-specific transcriptional environment involving activator protein-1 (AP-1; FOS-JUN complex), JUN, FOXN1, and SOX17. These findings provide new insights into the transcriptional regulation of progesterone responsiveness in avian reproductive tissues and advance our understanding of endocrine mechanisms underlying sperm storage. - Source: PubMed
Publication date: 2026/09/15
Matsuzaki MeiIchikawa KennosukeTerada TakumiEzaki RyoHoriuchi HiroyukiOhkubo TakeshiSasanami Tomohiro - Porcine epidemic diarrhea virus (PEDV) continues to cause devastating economic losses in the swine industry. However, the lack of species-specific in vitro models and reliance on costly animal models hinders development of effective interventions. We established a high-fidelity platform using porcine induced pluripotent stem cells (piPSCs; line VSMUi001-C) via a 28-day stepwise differentiation protocol. Successful lineage commitment was validated by OCT4 downregulation and robust FOXA2/SOX17 expression at day 5. By day 28, the piPSC-derived intestinal epithelial cells (piPSC-IECs) exhibited organized LGR5+ niches, MUC2+ goblet cells, and Villin+ enterocytes, mirroring native tissue architecture. Barrier functionality was confirmed by the continuous distribution of the tight junction protein zonula occludens-1 (ZO-1). Our results demonstrate that piPSC-IECs are permissive to PEDV and support productive infection, encompassing the complete viral life cycle from entry to release of infectious progeny. Productive replication was confirmed by direct immunodetection of viral antigen within inoculated cells. Viral challenge induced characteristic cytopathic effects and a specific pro-inflammatory elevation of tumor necrosis factor-alpha (TNF-α). Notably, infection fragmented ZO-1, providing a mechanistic explanation for the leaky gut phenotype observed in vivo. This platform serves as a robust system for investigating viral kinetics and host-pathogen interactions with high species-specific relevance. - Source: PubMed
Publication date: 2026/09/01
Muangthong TharathipChakritbudsabong WarunyaTaowan JarupaJantahiran PhakhinJaroensuk WanatchapornKaeoket KamponRungarunlert Sasitorn - The layered structure of the human vocal fold is unique to humans and absent in animals. Previous studies suggested that the maculae flavae at the anterior and posterior ends of the human membranous vocal fold are involved in the formation of this layered structure and that they serve as a stem cell niche nurturing tissue stem cells. This study aimed to examine the comparative histoanatomy of the gorilla vocal fold. - Source: PubMed
Publication date: 2026/09/10
Sato KiminoriNishimura TakeshiSato KiminobuSato FumihikoChitose Shun-IchiUmeno Hirohito