Ask about this productRelated genes to: SOX17 antibody
- Gene:
- SOX17 NIH gene
- Name:
- SRY-box 17
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2015-11-23
Related products to: SOX17 antibody
Related articles to: SOX17 antibody
- In birds, sperm storage tubules (SSTs) located at the uterovaginal junction (UVJ) facilitate long-term sperm storage and regulate sperm release in coordination with ovulation. In Japanese quail (Coturnix japonica), sperm release from SSTs might be mediated by membrane progestin receptor α (mPRα), encoded by the progestin and adipoQ receptor family member 7 (PAQR7) gene. Although PAQR7 plays an important role in reproductive functions, the mechanisms regulating its transcription remain unclear. Therefore, in this study, we investigated the transcriptional regulatory mechanisms of PAQR7 in Japanese quail SSTs. Reporter assays using serial deletion constructs identified multiple positive and negative regulatory regions within the 5' upstream region of PAQR7. Analysis of the proximal promoter region revealed a putative initiator element and non-canonical promoter structure. Electrophoretic mobility shift assays identified several nuclear protein-binding regions within the upstream regulatory region. Candidate transcription factors potentially binding to these regions were predicted using JASPAR and RNA-Seq transcriptome data. Quantitative PCR further revealed that FOS, JUN, FOXN1, and SOX17 levels were significantly upregulated in SST-containing tissues compared to those in non-SST epithelial tissues. Overall, our findings suggest that PAQR7 expression in SSTs is regulated by an SST-specific transcriptional environment involving activator protein-1 (AP-1; FOS-JUN complex), JUN, FOXN1, and SOX17. These findings provide new insights into the transcriptional regulation of progesterone responsiveness in avian reproductive tissues and advance our understanding of endocrine mechanisms underlying sperm storage. - Source: PubMed
Publication date: 2026/09/15
Matsuzaki MeiIchikawa KennosukeTerada TakumiEzaki RyoHoriuchi HiroyukiOhkubo TakeshiSasanami Tomohiro - Porcine epidemic diarrhea virus (PEDV) continues to cause devastating economic losses in the swine industry. However, the lack of species-specific in vitro models and reliance on costly animal models hinders development of effective interventions. We established a high-fidelity platform using porcine induced pluripotent stem cells (piPSCs; line VSMUi001-C) via a 28-day stepwise differentiation protocol. Successful lineage commitment was validated by OCT4 downregulation and robust FOXA2/SOX17 expression at day 5. By day 28, the piPSC-derived intestinal epithelial cells (piPSC-IECs) exhibited organized LGR5+ niches, MUC2+ goblet cells, and Villin+ enterocytes, mirroring native tissue architecture. Barrier functionality was confirmed by the continuous distribution of the tight junction protein zonula occludens-1 (ZO-1). Our results demonstrate that piPSC-IECs are permissive to PEDV and support productive infection, encompassing the complete viral life cycle from entry to release of infectious progeny. Productive replication was confirmed by direct immunodetection of viral antigen within inoculated cells. Viral challenge induced characteristic cytopathic effects and a specific pro-inflammatory elevation of tumor necrosis factor-alpha (TNF-α). Notably, infection fragmented ZO-1, providing a mechanistic explanation for the leaky gut phenotype observed in vivo. This platform serves as a robust system for investigating viral kinetics and host-pathogen interactions with high species-specific relevance. - Source: PubMed
Publication date: 2026/09/01
Muangthong TharathipChakritbudsabong WarunyaTaowan JarupaJantahiran PhakhinJaroensuk WanatchapornKaeoket KamponRungarunlert Sasitorn - The layered structure of the human vocal fold is unique to humans and absent in animals. Previous studies suggested that the maculae flavae at the anterior and posterior ends of the human membranous vocal fold are involved in the formation of this layered structure and that they serve as a stem cell niche nurturing tissue stem cells. This study aimed to examine the comparative histoanatomy of the gorilla vocal fold. - Source: PubMed
Publication date: 2026/09/10
Sato KiminoriNishimura TakeshiSato KiminobuSato FumihikoChitose Shun-IchiUmeno Hirohito - Primordial germ cells (PGCs) are the embryonic precursors of gametes, essential for transmitting genetic and epigenetic information across generations. However, PGC specification occurs within a narrow developmental window and involves only a small number of cells, making it difficult to study in vivo. In vitro models using pluripotent stem cells have enabled the generation of primordial germ cell-like cells, but these systems often rely on exogenous signaling and exhibit variability in efficiency and epigenetic fidelity. In this review, we synthesize current understanding of PGC specification in mouse and human systems, emphasizing the integration of signaling pathways, transcriptional networks, epigenetic reprogramming, and metabolic regulation. Canonical regulators, including PRDM1, PRDM14, TFAP2C, and SOX17, function within a broader, interconnected network that establishes for PGC competence. Understanding these interactions will be crucial for advancing in vitro gametogenesis and improving mammalian reproduction. - Source: PubMed
Publication date: 2026/09/03
Marshall MaddisonBevan ErylWang Yuan - SRY-box transcription factor 17 (Sox17) is essential for hepato-pancreato-biliary development. We identified two distributed enhancers of Sox17, Sox17e-13 and Sox17e-231, within the likely murine Sox17 topologically associating domain. Individual CRISPR-mediated enhancer deletions temporally reduce endodermal Sox17 expression, delaying the transition of bipotent ventral pancreato-biliary progenitor cells to a lineage-unipotent ventral pancreatic fate, reducing pancreas size and increasing gallbladder size. Deleting both enhancers further reduces Sox17 expression and delays conversion of bipotent progenitor cells to ventral pancreatic or biliary fates, reducing both pancreas and gallbladder size. Crossing each enhancer mutation to a Sox17 null allele revealed differential and profound sensitivities of the extrahepatic biliary system to alterations of Sox17 expression, as demonstrated by gallbladder hypoplasia, gallbladder agenesis with a cystic duct, and biliary atresia. These studies indicate that Sox17e-13 and Sox17e-231 additively modulate Sox17 expression, that the differentiation of bipotential ventral pancreato-biliary cells to unipotent fates is Sox17 dosage dependent, and that thresholds for Sox17 action during pancreato-biliary formation vary by developmental stage, further defining the role of Sox17 in hepato-pancreato-biliary formation and function. - Source: PubMed
Publication date: 2026/09/18
Finnel Ryan RMusselman Jessica RMcFadden Margaret ESilvestri Isabella MSkelton JenniferSampson Leesa LOsipovich Anna BWright Christopher V EMagnuson Mark A