Ask about this productRelated genes to: QPRT antibody
- Gene:
- QPRT NIH gene
- Name:
- quinolinate phosphoribosyltransferase
- Previous symbol:
- -
- Synonyms:
- QPRTase
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-16
- Date modifiied:
- 2014-11-19
Related products to: QPRT antibody
Related articles to: QPRT antibody
- Tertiary lymphoid structures (TLSs) are associated with superior prognosis in breast cancer (BC). TLSs serve as key niches of anti-tumor adaptive immune responses across various malignancies. However, the tumor-intrinsic factors that are associated with TLSs have been largely overlooked in BC. - Source: PubMed
Publication date: 2026/05/07
Li QiaoYang XinWei LanWang XingWang XiaosongChen JunxiaZhao LiuyangWen Siyang - Atherosclerosis (AS) remains a major cause of cardiovascular morbidity and mortality. Lactylation-a recently described post-translational modification linking cellular metabolism to gene regulation-has been implicated in vascular inflammation, yet its roles in AS are not fully defined. - Source: PubMed
Publication date: 2026/05/08
Ma YirongLi QimingWang MugeWan QiangLai JunyuWu JianguangWu Shuguang - Skin aging is an inevitable biological process caused by cellular senescence and overexposure to harmful environmental factors such as ultraviolet (UV) radiation. Senescent fibroblasts with proliferation arrest, mitochondrial dysfunction and nicotinamide adenine dinucleotide phosphate (NADPH) depletion have been proposed as a major mechanism driving skin photoaging, but the specific therapies are currently lacking. Inspired by the self-powering potential of plant-derived photosynthetic system, we herein fabricated a novel nanophotosynthetic platform that integrated Chlorella-derived nanothylakoid units (NTUs) with hyaluronic acid (HA)-based microneedles (MNs) to specifically target senescent fibroblasts for treating skin photoaging. By equipped with photosynthesis (PS)-I/II and quinolinate phosphoribosyltransferase (QPRT), the NTU-MN photosystem remarkably increased mitochondrial biogenesis and adenosine triphosphate (ATP) generation, resumed NAD(P)H pool and increased cellular anabolism, addressing the heighted bioenergetic and biosynthetic requirement for highly turnover of fibroblasts during photoaging. Furthermore, with skin penetrating ability of MNs and camouflaging of fibroblast membranes, topical application of the nanophotosystem facilitated the intradermal release of NTUs, leading to regeneration of damaged tissues, increased collagen synthesis, decreased senescence-associated secretory phenotype (SASP), and hence alleviated photoaging of skin. Thus, we developed a "green nanoplatform" with significantly anti-aging efficacy, biocompatibility, and biosafety, opening new avenues for light-driven therapies for degenerative diseases. - Source: PubMed
Publication date: 2026/05/17
Shou XinChen ChangjiangZeng LingyaoLiao WucanLiu ZhiyunWu DanHe ChengjieTan MiaomiaoLei LanjieShi Liyun - - Source: PubMed
Publication date: 2026/04/13
Wang KeyingLin Jie - Postpartum depression (PPD) is a common and serious mental disorder after childbirth, imposing a heavy burden on mothers, infants, and families. Abnormalities in the tryptophan-kynurenine (TRP-KYN) metabolic pathway are considered to be involved in its pathogenesis, but the role of quinolinic acid phosphoribosyltransferase (QPRT), a key downstream enzyme in this pathway, remains unclear. This study aims to explore the association between PPD in women undergoing cesarean section and gene polymorphisms, as well as other risk factors for PPD. - Source: PubMed
Zhao ShanshanLin GuoxinLi ZiyuanPing AnqiWang SaiyingDuan Kaiming