Ask about this productRelated genes to: QPRT antibody
- Gene:
- QPRT NIH gene
- Name:
- quinolinate phosphoribosyltransferase
- Previous symbol:
- -
- Synonyms:
- QPRTase
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-16
- Date modifiied:
- 2014-11-19
Related products to: QPRT antibody
Related articles to: QPRT antibody
- - Source: PubMed
Publication date: 2026/04/13
Wang KeyingLin Jie - Postpartum depression (PPD) is a common and serious mental disorder after childbirth, imposing a heavy burden on mothers, infants, and families. Abnormalities in the tryptophan-kynurenine (TRP-KYN) metabolic pathway are considered to be involved in its pathogenesis, but the role of quinolinic acid phosphoribosyltransferase (QPRT), a key downstream enzyme in this pathway, remains unclear. This study aims to explore the association between PPD in women undergoing cesarean section and gene polymorphisms, as well as other risk factors for PPD. - Source: PubMed
Zhao ShanshanLin GuoxinLi ZiyuanPing AnqiWang SaiyingDuan Kaiming - Biological sex has been shown to influence aging outcomes, contributing to distinct trajectories in disease susceptibility and lifespan. DNA methylation patterns provide a quantitative measure of biological aging. This study investigated whether aged male and female mice display distinct liver DNA methylation patterns and differences in epigenetic aging. Liver samples were collected from 17 aged c57BL/6 mice (6 males, 11 females). Genomic DNA was extracted and bisulfite-converted before targeted enrichment of 2,045 murine age-associated CpG loci. Biological age (DNAge) was estimated using a previously developed DNA methylation-based predictor generated through elastic net regression. The difference (ΔDNAge) between DNAge and chronological age was computed. Sex-specific differences were assessed by comparing site-specific methylation ratios, ΔDNAge values, and through principal component analysis (PCA) and multiple linear regression. Twelve CpG sites across six genes (, , , , , and ) showed significant sex-associated differences in methylation. demonstrated the largest and most consistent sex-associated effect, with all three associated CpG sites showing higher methylation in males (regression coefficients: -0.204, -0.281, and -0.294). exhibited consistent lower methylation ratios in females, whereas the other genes showed higher methylation in females. There were no sex differences in biological age or ΔDNAge ( = 0.596). Although the epigenetic clock did not reveal differences between sexes in aging, aged mice did exhibit sex-specific liver methylation patterns different from those reported in younger mice, suggesting that sex-dependent epigenetic changes may emerge later in life and may reflect sexual dimorphism in liver function with age. Males and females are known to age differently and develop certain diseases at different rates. Here, we examined the livers of aged male and female mice to see if they show different DNA methylation patterns. We found that aged male and female mice had distinct DNA methylation patterns at specific genes. Interestingly, most of these methylation differences were not present in younger mice, suggesting that sex differences in the genome may change with age. - Source: PubMed
Publication date: 2026/02/16
Apelian ShantMamillapalli RamanaiahUcar AbdullahGawde NimishaTaylor Hugh S - Colorectal cancer (CRC) is characterized by high mortality. Zinc finger protein ZIC2 plays a dual role in various cancers; however, its clinical value of ZIC2 in CRC remains unclear. - Source: PubMed
Publication date: 2026/01/29
Zheng LikenLiu HaoYang Ailing - Hyperuricemia (HUA) involves multi-organ dysfunction, particularly hepatic and renal abnormalities. Danggui-Niantong decoction (DGN) is a traditional formula for gout and chronic kidney disease. Clinically, DGN is often combined with drugs that regulate hepatic function to treat HUA. Anoectochilus roxburghii (AR) is recognized for its hepatoprotective properties. However, whether the AR and DGN combination (AR+DGN) exerts superior urate-lowering and organ-protective effects compared to monotherapy, and the mechanisms underlying this combined treatment, remain unclear. - Source: PubMed
Publication date: 2026/01/11
Li DongTao ZhuXu HangChen RongLei ShuwenLei MengjieZhou HaitaoMo YutingFu ChunhuaYu Longjiang