Ask about this productRelated genes to: PSMB4 antibody
- Gene:
- PSMB4 NIH gene
- Name:
- proteasome subunit beta 4
- Previous symbol:
- -
- Synonyms:
- HN3, PROS26
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-03
- Date modifiied:
- 2016-10-05
Related products to: PSMB4 antibody
Related articles to: PSMB4 antibody
- Aristolochic acids (AA) are naturally occurring carcinogens found in traditional herbal medicines derived from Aristolochia species. This study explores the potential link between AA and hepatocellular carcinoma (HCC), aiming to uncover key molecular targets driving AA-induced hepatocarcinogenesis. - Source: PubMed
Publication date: 2025/09/06
Liu CanQiao RuHe PengChen WangGao XiangtingHe Fuyuan - The interplay between host innate immunity and pathogen evasion is a dynamic battle shaping infection outcomes. The Topical Collection "Regulation of Antiviral and Antimicrobial Innate Immunity and Immune Evasion" synthesizes findings from thirteen recent studies to elucidate the molecular mechanisms of innate immune signaling and pathogen countermeasures. Host pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and DNA sensor cyclic GMP-AMP synthase (cGAS), drive type I interferon (IFN-I) and interferon-stimulated genes (ISGs) responses, alongside processes like autophagy and inflammasome activation, to combat viral and bacterial infections. Pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cytomegalovirus, and porcine reproductive and respiratory syndrome virus, deploy sophisticated strategies to target immune sensors and adaptors, enabling replication and persistence. Novel insights, including the roles of ISG15, autophagy protein ATG7, and host factors such as THAP11 and PSMB4, highlight complex interactions influencing viral replication and host defense. These studies propose targeted therapeutic strategies, such as inflammasome modulation for human immunodeficiency viruses (HIV), and prostaglandin E2 regulation for foot-and-mouth disease virus vaccine production, offering promising avenues to enhance host immunity and counter pathogen evasion. - Source: PubMed
Publication date: 2025/08/29
Wang LingHe DandanSatoh-Takayama NaokoZheng ChunfuXing Junji - The biological basis of the development of cancer of unknown primary (CUP) remains largely unknown, with no evidence of whether a common biological basis exists at present. Our previous multicenter clinical study predicted the primary site of CUP for site‑specific therapy. Concomitantly with the study, a microarray analysis of tumor mRNA samples obtained from 60 participants of the study with CUP was performed, and a gene expression profile specific to CUP was constructed. Several of the genes identified as being upregulated/downregulated in CUP could potentially be clinically useful common biomarkers of CUP. In the present study, to identify genes that may be more closely related to the development of CUP (characterized by its metastatic potential) among the upregulated genes, cell‑based small interfering RNA screening was performed , and two genes, protein kinase DNA‑activated catalytic subunit (PRKDC) and proteasome subunit β type‑4 (PSMB4), were identified to be possibly involved in the metastatic ability of CUP, since knockdown of these genes resulted in reduced migration of A549 cells. These genes were further knocked down in A549 cells using short hairpin RNAs (shRNAs) and the cells were implanted into the footpad of mice. Marked suppression of the metastatic ability of implanted cells from the footpad to the popliteal lymph node (LN) was observed in cells transfected with the shRNAs for PRKDC and PSMB4. In addition, bortezomib, a proteasome inhibitor, markedly reduced the ability of cells implanted into the footpad to metastasize to the LNs, as well as cell growth at the metastatic site, compared with vehicle or NU7447 (inhibitor of PRKDC). These findings indicated that proteasomal function activation augmented the metastatic ability of malignant CUP cells. - Source: PubMed
Publication date: 2025/05/02
Fujita YoshihikoDe Velasco Marco AHayashi HidetoshiNakagawa KazuhikoNishio Kazuto - Porcine reproductive and respiratory syndrome virus (PRRSV) is a single-stranded positive-sense RNA virus with an envelope. It-encoded non-structural protein 1α (nsp1α) plays a key role in evading host immune responses. Exploring the interaction between host factors and PRRSV nsp1α is crucial for understanding the mechanism of virus immune escape and virus control. Here, we constructed a cDNA library using porcine lung tissues and identified 33 potential host proteins interacting with viral nsp1α using yeast two-hybrid (Y2H) screening. These interactions were further analyzed using Gene Ontology and KEGG pathway analysis. Confocal microscopy revealed that proteasome subunit beta type-4 (PSMB4), carnosine dipeptidase 2 (CNDP2) and poly(rC) binding protein 1 (PCBP1) colocalized with viral nsp1α. The interaction between PSMB4 and nsp1α was further confirmed by Y2H and co-immunoprecipitation. PRRSV infection did not affect PSMB4 expression in both Marc-145 cells and porcine alveolar macrophages (PAMs). Overexpression of PSMB4 reduced nsp1α protein levels in a dose-dependent manner and decreased the accumulation of both viral N and nsp1α proteins in the context of PRRSV infection, while its knockdown promoted PRRSV replication. These data suggest that PSMB4 is a host restriction factor for PRRSV. Structure prediction and truncated mutant assays found that S146 and M148 within the mature chain domain of PSMB4 were crucial for binding and degrading nsp1α. These findings suggest that PRRSV nsp1α interacts with host proteins, with PSMB4 specifically binding to degrade nsp1α, thereby inhibiting PRRSV replication. - Source: PubMed
Publication date: 2025/04/07
Chen BinghuaChen YongjieHe ZhanPan YanfeiLuo YunyanYan JiecongLi FangfangGuo Chunhe - The poultry immune system is essential for protecting against infectious diseases and maintaining health and productivity. Cell-mediated immune responses (CMIs) protect organisms against intracellular pathogens. This study aimed to enrich the findings of genome-wide association studies (GWAS) by including several systematic gene set enrichment analyses (GSEA) related to cell-mediated immune responses in chickens. - Source: PubMed
Publication date: 2025/04/03
Kianpoor SomayehEhsani AlirezaTorshizi Rasoul VaezMasoudi Ali AkbarBakhtiarizadeh Mohammad Reza