Ask about this productRelated genes to: PRKY antibody
- Gene:
- PRKY NIH gene
- Name:
- protein kinase Y-linked (pseudogene)
- Previous symbol:
- -
- Synonyms:
- PRKYP, PRKXP3
- Chromosome:
- Yp11.2
- Locus Type:
- pseudogene
- Date approved:
- 1995-11-22
- Date modifiied:
- 2018-04-30
Related products to: PRKY antibody
Related articles to: PRKY antibody
- One of the main challenges in Type 1 diabetes mellitus (T1DM) research is the sample size of the participants and the invasive process of collecting an adequate number of blood samples from young patients with T1DM. Therefore, it is of great interest to investigate the possibility of using saliva as a non-invasive tool to investigate the genetic factors that are associated with T1DM comorbidities. The present study aims to identify differentially expressed genes (DEGs) in saliva samples of T1DM patients with various comorbidities using transcriptomic profiling. - Source: PubMed
Publication date: 2025/10/10
Mussa Bashair MSrivastava AnkitaRajan ReejaVenkatachalam ThenmozhiAl-Habshi AbeerAbdelgadir ElaminBashier AlaaeldinAl Awadi FatheyaHafidh KhadijaHamoudi RifatAbusnana Salah - The impact of biological sex on treatment response and prognosis in lung cancer remains poorly understood. This study investigates the relationship between sex-linked genes, DNA repair, senescence, and survival in male and female patients with lung cancer. - Source: PubMed
Publication date: 2025/09/20
Kinsella APrina-Mello AMarignol L - Sex discordance between cell-free DNA (cfDNA) testing and ultrasound examination is rare but can cause significant patient discomfort and uncertainty. Here, we present two clinical cases where a closer examination of raw sequencing data allowed us to anticipate possible discrepancies caused by the insertion of Y-chromosome regions into the maternal genome. We used Illumina's VeriSeq NIPT Solution v2 and a proprietary bioinformatics pipeline to analyze cfDNA in the maternal bloodstream. Paired-end sequencing data were aligned to the reference genome (). Non-duplicated aligned reads were aggregated into 100-kb bins, adjusted for CG bias, and further aggregated into 5-Mb windows. Z-scores were calculated for autosomes, sex chromosomes, and 5-Mb bins. The two clinical cases were classified as low-risk male fetuses according to the primary statistics (case A: NCV = 0.3; NCV = 40.6; native fetal fraction (FF) = 5.1%, and case B: NCV = -0.3, NCV = 40.7, FF = 10.8%); however, the Y-chromosome-based FF (FF) was significantly lower than the default FF estimate (FF ≅ 2% in both cases). Plots of X and Y chromosome Z-scores for each 5-Mb bin, according to genomic position, identified bins with Z-scores significantly higher than those expected for any pregnancy with a male fetus. The genomic coordinates of these bins overlapped with the amelogenin () and protein kinase Y-linked () genes, respectively. Amplification of these regions in the DNA isolated from the white blood cells fraction confirmed the presence of Y-chromosome insertions in the maternal genome. This study highlights a new source of discrepancy in cfDNA testing due to maternal genomic variations. These findings suggest the need for improvements to current bioinformatics pipelines to identify and exclude possible maternal perturbations from the classification algorithms used for aneuploidy and sex calls. - Source: PubMed
Publication date: 2025/01/20
Balaguer NuriaMateu-Brull EmiliaMartínez-Conejero Jose AntonioCervero AnaNavarro RoserJiménez-Almazán JorgeMilán Miguel - 46,XX testicular disorder/difference of sex development (46,XX DSD) is a rare congenital condition, characterized by a combination of the typical female sex chromosome constitution, 46,XX, and a variable male phenotype. In the majority of individuals with 46,XX DSD, a Y chromosome segment containing the sex-determining region gene (SRY) has been translocated to the paternal X chromosome. However, the precise genomic content of the translocated segment and the genome-wide effects remain elusive. - Source: PubMed
Publication date: 2024/10/08
Berglund AgnetheJohannsen Emma BSkakkebæk AnneChang SimonRohayem JuliaLaurentino SandraHørlyck ArneDrue Simon OBak Ebbe NorskovFedder JensTüttelmann FrankGromoll JörgJust JesperGravholt Claus H - To develop a methylation marker of Y-chromosome gene in the early diagnosis of prostate cancer (PCa). We utilized bioinformatics analysis to identify the expression and promoter methylation of Y-chromosome gene in PCa and other common malignancies. Single-center experiments were conducted to validate the diagnostic value of promoter methylation in PCa. expression was significantly down-regulated in PCa and its mechanism may be related to promoter methylation. promoter methylation is highly specific for the diagnosis of early PCa, which may be superior to prostate-specific antigen, mpMRI and other excellent molecular biomarkers. promoter methylation may be a potential marker for the early and accurate diagnosis of PCa. - Source: PubMed
Publication date: 2024/07/09
Dai ZhengChen HongbingFeng KaiwenLi TuoxinLiu WeifengZhou YibinYang DongrongXue BoxinZhu Jin