Ask about this productRelated genes to: POLR2E antibody
- Gene:
- POLR2E NIH gene
- Name:
- RNA polymerase II subunit E
- Previous symbol:
- -
- Synonyms:
- RPB5, RPABC1, XAP4, hRPB25, hsRPB5
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-07
- Date modifiied:
- 2016-07-11
Related products to: POLR2E antibody
Related articles to: POLR2E antibody
- International guidelines suggest prophylactic anticoagulation for patients with cancer at high risk of venous thromboembolism (VTE). Here, we evaluated whether tumor whole-genome sequencing data may improve the selection of high-risk patients. - Source: PubMed
Publication date: 2026/04/10
Mulder Frits IGuman Noori A Mvan Riet Jobvan Geffen Roos Jvan Haaps Thijs FHovsepjan Vahramvan Laarhoven Hanneke W MCirkel Geert Ade Vos Filip Y F LWestgeest Hans MBeerepoot Laurens Vde Vos-Geelen JudithLabots MarietteHamberg PaulVulink Annelie J ELos MaartjeZwinderman Aeilko HRobbrecht Debbie G Jde Jonge Maja J ABüller Harry RKamphuisen Pieter WFerwerda BartSteeghs Neeltjevan Es Nick - The RNA polymerase II (RNA pol II) complex is essential for gene transcription throughout life, and numerous cofactors have been identified as critical for diverse transcriptional processes. Herein, it is discovered that the RNA pol II complex is modulated by glutaminase 1 (GLS1), which affects lipid metabolism. In alcoholic fatty liver disease (AFLD), RNA pol II activation is observed, whereas RNA pol II inhibition reverse hepatic steatosis. Furthermore, high-protein diets are recognized for their adjuvant effect on patients with AFLD; glutamine is indispensable for its protective effects against hepatic steatosis, which is dependent on RNA pol II. Mechanistically, GLS1 acts as a chaperone that affects the RNA pol II complex in the nucleus by interacting with its subunits, POLR2H and POLR2E. In vivo studies have shown that hepatic overexpression of GLS1 ameliorates alcohol-induced fatty liver, whereas deficiency worsens this condition. Moreover, the overexpression of POLR2E or POLR2H, but not the truncated variants, abolishes the protective effects of GLS1 against alcohol-induced fatty liver. Thus, the study clarifies GLS1 as a cofactor involved in assembling the RNA pol II complex, regulating hepatic steatosis, and provides foundational insights for future therapeutic approaches in AFLD. - Source: PubMed
Publication date: 2025/09/11
Wu WenbiaoJiang HaowenLiu YichangPeng ChangWang HanlinYang WenhuaLyu ZanSun YanMa HuanGu HongyuKan WeijuanJing LiyaDong TianchengXia ChunmeiLei SaifeiWu RuiLi JinlongLi Jia - In this study, researchers aimed to explore the impact of intramuscular fat (IMF) concentration on the flavor of donkey meat, specifically in the longissimus dorsi muscle of Guangling donkeys. The internal volatile organic compounds that cause the flavor differences between donkey muscles are not clear at present. Transcriptomic technologies were utilized to analyze gene expression and its relationship to donkey meat flavor. - Source: PubMed
Publication date: 2024/07/29
Li WufengLiLi Wang Xi - Long non-coding RNAs' HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016, and HULC rs7763881 are progressively reported having a close genetic affinity with esophageal carcinogenesis in the East. Nonetheless, their correlation with variables already endorsed as significant prognostic factors in terms of staging, guiding treatment and predicting recurrence, metastasis, and survival have yet to be explored. Herein, we investigated their prognostic value by correlating them with clinicopathological and laboratory prognostic markers in esophageal cancer in the West. Formalin-fixed paraffin-embedded tissue specimens from 95 consecutive patients operated on for esophageal cancer between 2014 and 2018 were compared with 121 healthy community controls. HULC was not detected differently in any of the cancer prognostic subgroups. LINC00951 was underrepresented in Ca19.9 elevated subgroup. HOTAIR was more frequent in both worse differentiation grade and positive Signet-Ring-Cell and Ca19.9 subgroups. POLR2E was identified less frequently in Adenocarcinoma, Signet-Ring-Cell, and Diffuse histologies, as well as in Perineural, Lymphovascular, and Perivascular Invasion positive, while it was overrepresented in CEA positive subgroup. These lncRNAs polymorphisms may hold great potential not only as future therapeutic agents but also as novel markers for predictive analysis of esophageal cancer risk, clinical outcome, and survival. Clinical implications of these findings need to be validated with prospective larger sample-size studies. - Source: PubMed
Publication date: 2024/01/26
Baili EfstratiaGazouli MariaLazaris Andreas CKanavidis ProdromosBoura MariaMichalinos AdamantiosCharalabopoulos AlexandrosLiakakos TheodoreAlexandrou Andreas - The incidence of single-nucleotide-polymorphisms with malignant potential in esophageal cancer tissues has only been sparsely investigated in the west. Hence, we explored the contribution of four long non-coding RNAs' polymorphisms HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016 and HULC rs7763881 in esophageal cancer susceptibility. - Source: PubMed
Publication date: 2024/02/01
Baili EfstratiaGazouli MariaLazaris Andreas CKanavidis ProdromosBoura MariaMichalinos AdamantiosCharalabopoulos AlexandrosLiakakos TheodoreAlexandrou Andreas