Ask about this productRelated genes to: PNMT antibody
- Gene:
- PNMT NIH gene
- Name:
- phenylethanolamine N-methyltransferase
- Previous symbol:
- PENT
- Synonyms:
- -
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-12
- Date modifiied:
- 2015-08-25
Related products to: PNMT antibody
Related articles to: PNMT antibody
- Housing conditions, particularly environmental enrichment (EE), can influence experimental outcomes and welfare. While EE is generally regarded as beneficial, a male bias exists in research supporting this. This study investigated whether sex differences exist in levels of BDNF in the brain and peripheral tissues in environmentally enriched mice. Expression of the catecholamine biosynthetic enzymes of the adrenal glands, key to the sympathoadrenal medullary system and stress response, was also investigated. We showed that female mice exposed to EE exhibited increased anxiety-like behaviors. EE in male mice did not induce anxiety-like behavior, and it was associated with increased hippocampal and pituitary BDNF expression, suggestive of enhanced neurotrophic support. In the adrenal gland, the levels of adrenal catecholamine biosynthetic enzymes, specifically total tyrosine hydroxylase and PNMT levels, were increased in females, but not in males. In conclusion, EE may serve as a mild stressor in female mice. In male mice, EE may have induced neurotrophic support of the hippocampus since hippocampal BDNF levels were increased with minimal changes to adrenal catecholamine synthetic enzymes. This study highlights the importance of considering sex as a biological variable in translational neuroscientific research. - Source: PubMed
Herselman M FLuo S YLin L YZhou X FBobrovskaya L - To systematically identify potential pathological molecular and therapeutic targets for type 2 airway inflammatory diseases using Mendelian randomization (MR) and co-localization analysis. - Source: PubMed
Jiang ZihanMeng JuanLiu Shixi - A precise diagnosis and customized treatment become more difficult by the genomic heterogeneity of breast cancer (BRCA). In order to examine gene expression data from two separate Gene Expression Omnibus (GEO) microarray datasets, we used a integrative approach in this study that combined bioinformatics and machine learning. We were able to distinguish between universal and subtype-specific transcriptome patterns by identifying both common and subtype-specific differentially expressed genes (DEGs) using dual-level differential expression analysis. Functional enrichment analysis and the creation of protein-protein interaction networks identified important hub genes, including , and which showed substantial dysregulation and were linked to high mutation rates and a bad prognosis. Survival analyses, which identified as a predictive predictor for the general population and for the Luminal B subtype, highlighted the clinical significance of these hub genes. We used both Random Forest and K-Nearest Neighbors classifiers to ensure robust biomarker identification. In the analysis, we prioritized 35 model-agnostic biomarkers that performed well in subtype categorization, such as and . This dual-model approach improved the reliability of biomarker identification while reducing model-specific biases. These results set the stage for early identification, more accurate subtype classification, and possible therapeutic targeting in breast cancer. - Source: PubMed
Publication date: 2026/03/09
Goel PrashanshaShaikh Nilofer - We examined the distribution of axons throughout the spinal cord of the rat that were either immunoreactive for the adrenaline-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), or derived from medullary C1 neurons, one of the three groups of neurons in the brain that synthesize PNMT. We observed that PMNT-immunoreactive axons, as well as C1 axons labelled with GFP from viral transduction, innervate most, but not all, sympathetic preganglionic neurons in the thoracolumbar spinal cord. GFP-positive C1 axons provided innervation to sympathetic preganglionic neurons that expressed cocaine and amphetamine regulated transcript, an accepted marker of sympathetic vasomotor neurons. In addition, we observed axons from PNMT-containing and C1 neurons caudal to the distribution of sympathetic preganglionic neurons in the sacral spinal cord where they closely apposed parasympathetic preganglionic neurons retrogradely labelled from the major pelvic ganglion. We also found close appositions from PNMT-immunoreactive or GFP-labelled C1 axons on choline acetyltransferase-stained parasympathetic preganglionic neurons activated by the micturition reflex, thus providing clear evidence of a non-cardiovascular target for RVLM C1 neurons. Furthermore, we observed a few PNMT-positive and GFP-positive C1 axons making close appositions with somatic motor neurons in Onuf's nucleus in the sacral cord and in the ventral horn at more rostral levels. These data provide a comprehensive map of the distribution of adrenergic inputs to the spinal cord and identify parasympathetic preganglionic neurons, including those involved in the micturition reflex, as well as sympathetic preganglionic neurons as the major targets for these inputs. - Source: PubMed
Llewellyn-Smith I JTravis LConnelly A ABassi J KMenuet CAllen A M - Silkie (SK) chickens, valued for dark meat, serve as a model to study melanin deposition in muscle. Integrated transcriptomics and metabolomics of SK vs. Arbor Acres (AA) broiler pectoralis were used to identify key molecular drivers of meat color. All birds were cage-raised under standardized temperature and light conditions with free access to feed and water. Pectoralis muscle samples were collected from 24-day-old healthy SK and AA chickens ( = 6). Transcriptome profiling identified 488 differentially expressed genes in SK chickens, with seven conserved melanogenesis genes (, , , , , , ) consistently upregulated across dark-pectoralis breeds, and melanogenesis and WNT pathways were activated. Co-expression network analysis highlighted as a key hub regulator. Metabolomics quantified 129 differentially abundant metabolites. A critical finding was the significant depletion of L-tyrosine and its derivatives in SK muscle, despite upregulated melanogenesis genes. It indicates intense metabolic flux toward pigment synthesis. Integrated analyses converged on tyrosine metabolism and redox pathways: oxidized glutathione and p-coumaric acid correlated negatively with pigment deposition, while ADP-ribose and pyridoxal correlated positively. Additionally, novel inhibitors and may modulate melanin deposition. These findings reveal a trade-off between pigment deposition and redox balance, providing molecular markers for poultry melanin-related trait improvement. - Source: PubMed
Publication date: 2026/01/14
Pan YuxianZhang LinYue XinSun ZhenZhang HuaiyongSi XuemengZheng RuiChen WenZhang MengHuang Yanqun