Ask about this productRelated genes to: PMEL antibody
- Gene:
- PMEL NIH gene
- Name:
- premelanosome protein
- Previous symbol:
- SIL, SILV
- Synonyms:
- D12S53E, SI, Pmel17, gp100
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-24
- Date modifiied:
- 2016-06-10
Related products to: PMEL antibody
Related articles to: PMEL antibody
- Edible bird's nest (EBN) benefits skin, but its transgenerational effects are unknown. This study investigated whether maternal EBN or its key component, sialic acid (SA), could program offspring skin pigmentation and antioxidant capacity. - Source: PubMed
Publication date: 2026/03/28
Zhang WenruiZhang YijiaWang XinyuanChen YujuanChen LiqinGao JieLi YixuanWang DongliangSun Yanan - The aim of the study was to determine how the chemotherapeutic alkylating agent dacarbazine, together with the application of the miR-204-5p mimic in vivo, affects the presence of disseminated melanoma cells in distant organs - the lungs and liver. - Source: PubMed
Publication date: 2026/04/01
Lapkina EkaterinaRuksha Tatiana - Animal colouration is a key trait in organismal biology, being involved in natural and sexual selection, competition, and communication. Amphibians use their highly diverse colouration in many ecological interactions, but the molecular bases of their colour variation are less well understood than in other vertebrate systems. While the genetic, structural, and cellular bases of pigmentation are increasingly understood in a range of models, potential epigenetic or epitranscriptomic effects are almost completely unexplored. The fire salamander (Salamandra salamandra) has striking colour patterns and polymorphisms, but the extremely large genome size of salamanders makes traditional genetic analyses infeasible. To discover loci and molecular mechanisms underlying colour differences in salamanders, we used long-read direct RNA sequencing to test the roles of RNA methylation, gene expression and their relationship on intra- and inter-individual colour variation in black, yellow and brown skinned salamanders. We found 129 differentially expressed and 281 differentially methylated genes across all pairwise comparisons. Many of the genes involved are related to pigmentation, with several directly associated with melanin production, such as Melan-A (MLANA), Premelanosome protein (PMEL), Tyrosinase (TYR) and Tyrosinase-related protein 1 (TYRP1). We found both a positive overall correlation and a significant overlap in transcripts that are differentially methylated and expressed. These findings suggest multiple molecular mechanisms, including gene expression and RNA methylation, contribute to amphibian colour diversity. RNA modifications as a promising area for understanding morphological variation in non-model animals and their impact on their ecology. - Source: PubMed
Strowbridge NicholasVieites David RRitchie Michael GElmer Kathryn R - Mitochondria form contact sites with multiple organelles to coordinate diverse cellular processes. Melanosomes, lysosome-related organelles, undergo stepwise maturation to synthesize and store melanin, but how they interact with mitochondria remains unclear. Here we show that mitochondria-melanosome contacts dynamically increase during melanosome maturation and are mediated by STIM1-MFN2 interactions. Using a NanoBiT-based reporter system, MiMSBiT (Mitochondria-Melanosome contact reporter applying NanoBiT), to monitor reversible mitochondria-melanosome contacts in living cells, we demonstrate that STIM1 localizes to melanosomes and promotes their contact with mitochondrial MFN2. A transient decrease in melanosomal lumen calcium induces STIM1 clustering and enhances its association with MFN2. These contacts locally increase mitochondrial ATP availability, leading to melanosome lumen acidification via proton channel activation. This acidification facilitates PMEL fibrillation, a key step in melanosome maturation. Together, our findings reveal a mechanism by which mitochondria-melanosome contacts regulate melanosome maturation. - Source: PubMed
Publication date: 2026/03/06
Shiiba IsshinIshikawa YutoOshio HijiriIto NaokiYamaguchi FuyaNagashima ShunAndo HideyaUmezawa KeitaroMiura YuriAraiso YuheiNakamura KokiHirabayashi YusukeInatome RyokoYanagi Shigeru - The molecular effects involved in the cellular response to ultraviolet A1 (UVA1) exposures in human skin are incompletely understood. - Source: PubMed
Publication date: 2026/02/08
Haapasalo AnninaLiong OliviaJernman JuhaYlianttila LasseSnellman ErnaPasternack RafaelPartonen TimoKarisola Piia