Ask about this productRelated genes to: PKLR antibody
- Gene:
- PKLR NIH gene
- Name:
- pyruvate kinase L/R
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: PKLR antibody
Related articles to: PKLR antibody
- Persistent pulmonary hypertension of newborn (PPHN) occurs due to the impairment in the expected fall in pulmonary vascular resistance during the fetal to neonatal circulatory transition, with a prevalence of 1.9 per 1000 live births, and a significant mortality rate of 4-33%. - Source: PubMed
Publication date: 2026/03/13
Mani SrinivasanBerger Seth I - In order to explore the main regulatory genes and related pathways of growth traits, transcriptome sequencing was performed on the hypothalamus, pituitary, and liver tissues of 12-month-old greater amberjack () with different growth rates. In total, 504 (118 up- and 386 down-regulated), 556 (283 up- and 273 down-regulated), and 699 (224 up- and 475 down-regulated) differentially expressed genes (DEGs) were identified in the hypothalamus, pituitary, and liver tissues, respectively. GO and KEGG pathway analyses revealed significant differences in the expression of several genes involved in growth, metabolism, and immune-related pathways. The mRNA expression levels of genes related to growth (, , ), cell proliferation (, , , , and ), and lipid metabolism (, , , , and ) were up-regulated in the fast-growing (FG) group, while the and were down-regulated. Conversely, genes associated with glycolysis (, , ), citrate cycle (, ), and immune-related pathways (, , , , , , and ) were up-regulated in the slow-growing (SG) group. These findings indicate that the FG exhibited greater lipid metabolism capacity and cell proliferation ability, while the SG expended additional energy to cope with environmental stress, with hindered growth during immune response. This study enhances our understanding of the genetic mechanisms underlying differences in growth rates and provides essential gene resources for future growth-related molecular breeding programs in greater amberjack. - Source: PubMed
Publication date: 2026/02/06
Ru XiaoyingLi XiaojingHuang YangChen PeipeiDeng QiuxiaLi HangZhou QibingLin HaoyiHao RuijuanLiao YongguanWu JinhuiZhao YanfeiZhu Chunhua - The flavor of chicken meat is a major determinant of consumer preference, yet its genetic basis remains poorly understood. Here, we integrated volatile metabolomics, RNA-seq, proteomics, and phosphoproteomics of breast muscle from Qingyuan partridge chicken (QPC) and Cobb broiler (CB). 318 volatile compounds were detected, among which eight (2-pentylfuran, isophorone, 2-undecanone, benzaldehyde, pentanal, 2-heptanone, ethyl acrylate, and 1-octanol) were key differentiators between breeds. Multi-omics analysis revealed carbohydrate metabolism genes (GPI, PGM1, FBP2, LDHA, PGAM1, PGK2, LDHB, PFKM, PKLR, ALDOA, LOC107050559) significantly correlated with key volatile compounds, with GPI and LDHA correlated with all key compounds across expression and phosphorylation levels. Importantly, we identified a PPP1R3A-PPP1CA-GYS1 phosphorylation axis that regulates glycogen metabolism and thereby influences precursor content for Maillard reactions. These findings suggest that carbohydrate metabolism and its phosphorylation cascades may contribute to meat flavor, providing a molecular basis for genetic improvement in poultry. - Source: PubMed
Publication date: 2026/01/20
Yang XinChai XuewenGong JishangLuo WenXu Jiguo - Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy characterized by altered lactate metabolism, where traditional prognostic indicators are insufficient for precision medicine. This study aimed to construct an enhanced CT radiomics model integrated with lactate metabolism gene-related (LMGR) genomic signatures for HNSCC prognosis using TCGA and TCIA databases. A cohort of 399 HNSCC patients was analyzed. Analysis of 204 lactate-related genes identified 24 differentially expressed LMGR genes (DELMGR). Univariate Cox regression revealed that among these, PKLR, IL19, and CXCL9 exhibited protective effects (HR = 0.932, 0.885, and 0.931, respectively). A lactate classification score (LCS) was derived from the analysis of these three genes, demonstrating a significant correlation with overall survival (OS) in both univariate (HR = 1.807, 95 % CI: 1.346-2.424, P < 0.001) and multivariate assessments (HR = 1.772, 95 % CI: 1.296-2.424, P < 0.001). From enhanced CT images, 2060 radiomic features were extracted. Subsequently, after feature selection using mRMR and RFE algorithms, a support vector machine (SVM) model was built to predict LCS, which generated a radiomics score (RS). The model demonstrated AUC values of 0.773 and 0.760 in the training and validation datasets, respectively. The RS distribution significantly differed between lactate subtypes in the training cohort (P < 0.001), with specifically higher RS in the high-risk LCS group. High RS was associated with poor OS (HR = 3.582, 95 % CI: 1.240-10.348, P = 0.018) and was correlated with clinical features such as the perineural invasion and the margin status. Mechanistic analysis indicated that the high RS group was enriched in an immunosuppressive microenvironment and was associated with fatty acid metabolism pathways. This enhanced CT-based radiomics model effectively predicts lactate-based stratification, demonstrating potential prognostic value in HNSCC and providing novel biomarkers as well as a non-invasive predictive tool for prognostic assessment. - Source: PubMed
Publication date: 2026/01/17
Yuan HaotianYuan LinChen JiapengShi NaixuLin DetongWang XinyuKong ChenfeiWang Xiaofeng - Growing evidence indicates that PKLR, the gene for pyruvate kinase (PK), is a genetic modifier of the sickle cell phenotype. Coinheritance of specific PKLR variants is associated with increased pain-related hospitalization and can trigger sickle cell disease (SCD) phenotypes in asymptomatic carriers. PK deficiency disrupts RBC glycolysis, leading to ATP deficits and accumulation of 2,3-diphosphoglycerate, which exacerbates sickling in SCD. Using CRISPR-Cas9, we generated null mutations in Pklr [Pklr(13ntdel/13ntdel) or Pklr(246ntdel/246ntdel)] specific for the RBC isoform (PKR) in Townes mice that were homozygous (SS) or heterozygous (AS) for the human sickle globin gene, or homozygous for human hemoglobin A (AA, controls), to investigate the effect of PKR deficiency on the sickle phenotype in mice. PKR-deficient AA and AS mice developed severe anemia, reticulocytosis, and substantial spleen and liver iron deposits. Unlike what is observed in humans, PKR deficiency in AS and SS mice surprisingly decreased sickling, but it was also associated with increased extramedullary hematopoiesis and mitochondrial retention in mature RBCs. These results demonstrate the differential effect of Pklr mutations on the phenotype of both AS and SS mouse models, offering insights into the complex role of PKR deficiency in SCD pathology. - Source: PubMed
Publication date: 2026/01/08
Wang XundeSmith MeghannKamimura SayuriLi QuanShah NiharikaQuezado MarthaAlmeida Luis EfVogel SebastianTegegn Mickias BSun Kevin YVillasmil RafaelLiu ChengyuEaton William AThein Swee LayQuezado Zenaide Mn