Ask about this productRelated genes to: PIH1D2 antibody
- Gene:
- PIH1D2 NIH gene
- Name:
- PIH1 domain containing 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2007-01-31
- Date modifiied:
- 2018-06-04
Related products to: PIH1D2 antibody
Related articles to: PIH1D2 antibody
- R2SP belongs to the R2TP-like quaternary chaperone family and consists of RUVBL1/RUVBL2 AAA+ ATPases, which powers the machinery, and SPAG1 and PIH1D2 adapter proteins that engage specific clients to promote their quaternary assembly. However, little is known about the structure of R2SP and the precise mode of action of these R2TP-like complexes. Here, we combined biochemical (ATPase and fluorescence polarization assays) and structural approaches (NMR, structural mass spectrometry, cryo-EM) to investigate the 3D organization of the R2SP complex, its mode of assembly and ATPase activity. Together with our binding, mutational and kinetic studies, these results led us to propose a model in which SPAG1 and PIH1D2 bind and cooperatively engage RUVBL1/RUVBL2 to produce R2SP. This reveals a 3D structure close to the canonical R2TP complex but also highlights differences in RUVBL1/RUVBL2 ATPase activity, as well as the cooperative binding of SPAG1 and PIH1D2 to this catalytic core that may explain functional difference between the two systems. - Source: PubMed
Publication date: 2026/02/10
Santo Paulo EChagot Marie-EveGizardin-Fredon HugoLey MarieChenuel ThomasDeslignière EvolènePlassart LauraPaiva Ana C FSousa Pedro M FBertrand EdouardCharpentier BrunoVerheggen CélineQuinternet MarcMeyer PhilippeBandeiras Tiago MCianférani SarahPlisson-Chastang CéliaManival Xavier - Glioma, the most prevalent primary brain tumor, exhibits dysregulated ribosome biogenesis closely linked to malignant behavior. However, the role of ribosome biogenesis in glioma and prognosis remains incompletely understood. This study aimed to construct a molecular signature based on ribosome biogenesis-related genes to predict patient survival and therapeutic response in glioma. - Source: PubMed
Publication date: 2025/10/08
Li YadanTang XiaolongZhao WenhuiSi XiuwenCui YanfangDong YanbinLiu Yongshuo - Cancer-associated hypersialylation is believed to be related to the metastatic cell phenotype and the suppression of sialyltransferases (SiaTs) has been suggested to be a potent preventive strategy against metastasis. The present research discovered SiaTs-related genes for cervical cancer (CC). - Source: PubMed
Publication date: 2025/05/22
Shao JiaZhang CanTang YaonanHe AiqinCheng Xiangyan - A lot of studies have shown a close relationship between cuproptosis and cancer. The main purpose of this study is to analyze the impact of cuproptosis on cervical cancer (CC). - Source: PubMed
Publication date: 2025/01/21
Liu XueLi WeiYang ChunLuo JudongTang Bin - : Genes and environments were transmitted across generations. Parents' genetics influence the environments of their offspring; these two modes of inheritance can produce a genetic nurture effect, also known as indirect genetic effects. Such indirect effects may partly account for estimated genetic variance in T2D. However, the well-established specific genetic risk factors about genetic nurture effect for T2D are not fully understood. This study aimed to investigate the genetic nurture effect on type 2 diabetes and reveal the potential underlying mechanism using publicly available data. : Whole-genome genotyping data of 881 offspring and/or their parents were collected. We assessed SNP-level, gene-based, and pathway-based associations for different types of genetic effects. : Rs3805116 (β: 0.54, = 4.39 × 10) was significant for paternal genetic nurture effects. ( = 1.58 × 10), ( = 6.76 × 10), and ( = 2.67 × 10) revealed significantly positive paternal genetic nurture effects. Five ontologies were identified as enrichment in both direct and indirect genetic effects, including flavonoid metabolic process and antigen processing and presentation via the MHC class Ib pathway. Two pathways were only enriched in paternal genetic nurture effects, including the transforming growth factor beta pathway. Tissue enrichment of type 2 diabetes-associated genes on different genetic effect types was performed using publicly available gene expression data from the Human Protein Atlas database. We observed significant gene enrichment in paternal genetic nurture effects in the gallbladder, smooth muscle, and adrenal gland tissues. : , , and are associated with increased T2D risk through the environment influenced by paternal genotype, suggesting a novel perspective on paternal contributions to the T2D predisposition. - Source: PubMed
Publication date: 2025/01/07
Li XiaoyiZhou ZechenMa YujiaDing KexinXiao HanWu TaoChen DafangWu Yiqun