Ask about this productRelated genes to: PGAM2 antibody
- Gene:
- PGAM2 NIH gene
- Name:
- phosphoglycerate mutase 2
- Previous symbol:
- -
- Synonyms:
- PGAM-M
- Chromosome:
- 7p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
Related products to: PGAM2 antibody
Related articles to: PGAM2 antibody
- To characterize the transcriptional and physiological alterations induced by manganese stress in , juveniles (mean weight 5.0 ± 0.2 g) were subjected to either manganese exposure (5.50 ± 0.03 mg/L) or control (0 mg/L) for a 12 h period. Subsequently, gill tissues were excised for evaluation of antioxidant parameters and RNA-Seq analysis. A total of 753 DEGs were identified in the manganese exposure group compared to controls, comprising 287 up-regulated and 466 down-regulated genes. GO and KEGG enrichment analysis of DEGs showed that most of the DEGs were involved in immune and metabolic pathways, which disturbed the biological processes related to immunity and metabolism at the molecular level. The acute manganese stress initiated a multi-level antioxidant response to cope with oxidative stress in . This finding was further supported by the significant increase in MDA content and significant decrease in GSH content and GSH-Px activity under manganese exposure, while SOD and CAT activities were significantly increased. Simultaneously, the acute manganese stress triggered profound metabolic reprogramming to cope with energy pressure in , which showed that manganese exposure significantly down-regulated energy metabolism-related genes (, , , , , , , ); furthermore, the overall energy metabolism network was widely inhibited, while lipid metabolism-related genes (, ) were significantly up-regulated to compensatorily activate fatty acid transport and β-oxidation pathways. In addition, the acute manganese stress initiated a complex immune response pattern to cope with cell damage in , which showed that manganese exposure significantly enhanced the expression of inflammatory signaling genes (, , ); furthermore, certain inflammatory pathways were activated, while the expressions of immune regulatory genes (, ) were significantly decreased. In summary, these results indicated that manganese exposure could impair immune function, disrupt metabolism, and induce oxidative stress in . - Source: PubMed
Publication date: 2026/03/20
Shen XiaoluWang YongliRen MingchunHuang DongyuGu JiazeZhang LeiminLiang HualiangChen Xiaoru - The heterogeneous etiology and limited therapeutic options of pediatric restrictive cardiomyopathy (RCM)underscore the urgent need to elucidate its molecular mechanisms and identify potential treatment targets. - Source: PubMed
Publication date: 2026/03/24
Fu XihangLiu JieGuo QingWang LinWu JingWu ZuboXing YanlinZhu PengDong NianguoShi JiaweiPeng Hua - The cryopreservation of semen from the Inner Mongolia cashmere goat, a valuable dual-purpose breed in China, results in a sharp decline in sperm motility, hindering genetic improvement and germplasm propagation. This study aimed to investigate the protective effects and underlying mechanisms of skim milk as a supplement in a cryopreservation extender. - Source: PubMed
Publication date: 2026/01/14
Xue Shan-HuiXu Bing-BingLi Wen-ZeZhang Jia-XinSu Rui - With intensifying global climate change and human activities, and with regional topography interactions, soil and water salinization has intensified, posing major ecological and environmental challenges worldwide. Here, we integrated histology, transmission electron microscopy, RNA sequencing (RNA-seq) and data-independent acquisition (DIA)-based proteomics to profile hepatopancreas responses of during acute sulfate stress (≤48 h). Sulfate exposure disrupted tubular architecture and organelle integrity, consistent with early cellular injury. Multi-omics analyses revealed metabolic reprogramming marked by suppressed glycolysis (e.g., HK2, ENO) and enhanced oxidative phosphorylation (e.g., ATP5F1B), together with activation of calcium signaling (e.g., SLC8A1, ADCY9) and reinforcement of antioxidant/one-carbon and glucose-branch pathways (e.g., SHMT2, PGAM2). These coordinated transcript-protein changes indicate a shift from rapid cytosolic ATP supply to mitochondrial ATP production while buffering Ca overload and reactive oxygen species. Collectively, our results delineate the physiological and molecular adjustments that enable to cope with sulfate conditions and provide mechanistic targets for selective breeding and water-quality management in saline-alkaline aquaculture. - Source: PubMed
Publication date: 2026/01/21
Wang RuixuanGu ChenLi HuiWang LibaoSun RuijianFu KuipengShi WenjunWan Xihe - The silver pomfret (Pampus argenteus), a vital aquaculture species, is highly susceptible to Vibrio parahaemolyticus infections, yet the molecular mechanisms underlying its immune response remain poorly understood. This study investigated gill responses to V. parahaemolyticus infection via intraperitoneal injection, analyzing histopathological, transcriptomic, and enzymatic changes at 3, 6, 12, 24 and 48 h post-infection (hpi). Histological analysis revealed progressive gill damage, with significant architectural disruption from 6 hpi and severe lesions by 48 hpi. Transcriptome profiling of 18 cDNA libraries generated 40-67 million clean reads, yielding 4492-5231 differentially expressed genes (DEGs) across time points, with 1094-2174 unique DEGs per time point. Inflammatory cytokines (tnf-α, il-1β, il-8, il-12) showed robust upregulation, peaking at 6-24 hpi, indicative of an active immune response. Gene Ontology (GO) and KEGG analyses identified enriched pathways, including "oxidative phosphorylation" (3-48 hpi) and "tight junction" (24 hpi), with "oxidoreductase activity" and "aerobic respiration" as the dominant functional categories. Oxidative stress markers (MDA, SOD, CAT, POD) exhibited time-dependent increases, reflecting enhanced antioxidant defenses. Weighted Gene Co-expression Network Analysis (WGCNA) revealed the turquoise module as being strongly correlated with infection, identifying hub genes (gapdh, gapdhs, pgam2, g6pd, taldo1, pgam1a) critical to immune regulation. This study is the first to systematically investigate the temporal crosstalk between inflammatory responses, oxidative stress, and metabolic reprogramming in silver pomfret gills during V. parahaemolyticus infection, providing novel molecular targets for the control of vibriosis. - Source: PubMed
Publication date: 2026/01/12
Zhou DianyangHan PingXue YadongSun ZhennanWang LongdiLiu XiumeiChen JianmingWang YajunZhou SumingSun XueDu XinxinWang Xubo