Ask about this productRelated genes to: PDSS2 antibody
- Gene:
- PDSS2 NIH gene
- Name:
- decaprenyl diphosphate synthase subunit 2
- Previous symbol:
- C6orf210
- Synonyms:
- bA59I9.3, COQ1B
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2019-03-13
Related products to: PDSS2 antibody
Related articles to: PDSS2 antibody
- The purpose of this study is to ascertain the incidence of fatigue and to determine the cross-sectional associate and related variables of fatigue in patients with Parkinson's disease (PD). - Source: PubMed
Publication date: 2026/07/15
Ning HaiboChen LeiWang MinLv NingChen Lihua - Sleep disturbances are highly prevalent among elderly patients with Parkinson disease (PD), substantially impairing their quality of life. This study aimed to identify associated risk factors and to develop and validate a nomogram risk prediction model based on multidimensional data, providing a practical tool for early clinical identification and intervention. A retrospective case-control study was conducted on 340 elderly PD patients admitted to a tertiary hospital between June 2023 and June 2025. Multidimensional data were collected through self-designed questionnaires, standardized clinical scales, and electronic medical records. Patients were classified into a sleep disorder group and a non-sleep disorder group using the second version of the Parkinson Disease Sleep Scale (PDSS-2) with a cutoff score of ≥18. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors, which were subsequently incorporated into the nomogram model. Model discrimination was assessed by the receiver operating characteristic (ROC) curve, while calibration was evaluated using bootstrap resampling and calibration plots. The prevalence of sleep disturbances in elderly hospitalized PD patients was 61.2%. Multivariate analysis identified advanced Hoehn-Yahr stage, higher UPDRS-II score, severe nocturnal pain, increased nocturia frequency, and elevated HADS-depression scores as independent predictors of sleep disturbances. The developed nomogram demonstrated good discriminative ability, with an area under the ROC curve (AUC) of 0.867, sensitivity of 0.884, and specificity of 0.765. The Hosmer-Lemeshow test indicated satisfactory model calibration. Sleep disturbances are common in elderly hospitalized PD patients and are influenced by multiple clinical factors. The proposed nomogram model exhibits favorable predictive performance and calibration, offering an effective clinical tool for risk stratification and facilitating early intervention. - Source: PubMed
Wu LinlinZhang LiWu Yanyan - Primary coenzyme Q10 (CoQ10) deficiency (PCOQ10D) is an autosomal recessive mitochondrial disorder caused by pathogenic variants in genes involved in the CoQ10 biosynthetic pathway, including PDSS2, COQ2, COQ6, and COQ8B/ADCK4. Among these, pathogenic variants in the COQ2 gene impair oxidative phosphorylation and mitochondrial biogenesis in podocytes, often leading to encephalopathy and nephropathy. - Source: PubMed
Yue YuqiZhao FeiChen Qiuxia - Medical cannabis (MC) has emerged as a potential therapy for Parkinson's disease (PD), targeting motor and nonmotor symptoms (NMS), such as pain, sleep disturbance, and urinary dysfunction. Cannabinoid receptors in central and peripheral systems, including the bladder, provide a mechanistic basis for symptom modulation. This study evaluated the feasibility, safety, and preliminary clinical effects of MC on NMS in PD within a real-world, regulated framework. - Source: PubMed
Publication date: 2026/06/16
Anis OmerLassman SimonGoldberg TomerSaar AdiMeiri DavidShapira AnnaFay-Karmon TsviaEphraty LilachHassin-Baer SharonAnis Saar - Subcutaneous foslevodopa/foscarbidopa (LDp/CDp) infusion is approved for treating motor fluctuations and dyskinesias in patients with advanced Parkinson's disease (aPD). However, efficacy data on non-motor symptoms (NMS) are limited. - Source: PubMed
Publication date: 2026/06/08
Jander AlinaBergner SarahSchönwald BeatePötter-Nerger MonikaBuhmann CarstenHidding Ute