Ask about this productRelated genes to: PDSS2 antibody
- Gene:
- PDSS2 NIH gene
- Name:
- decaprenyl diphosphate synthase subunit 2
- Previous symbol:
- C6orf210
- Synonyms:
- bA59I9.3, COQ1B
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2019-03-13
Related products to: PDSS2 antibody
Related articles to: PDSS2 antibody
- Early detection of Parkinson's disease (PD) benefits from innovative approaches such as large-scale online surveys on different risk factors in the general population. Effective dissemination is essential, yet little is known about the relative reach and recruitment patterns of different strategies. - Source: PubMed
Publication date: 2026/08/05
Pilco-Janeta Daniel FMahlknecht PhilippDe la Cruz-Puebla MyriamHorlings CorinneGarrido AliciaMarques Taina MSoare RuxandraTheyer ChristophLeiter SimonGhosh SoumyabrataRege KavitaEgner IrisGales Jón PolSchade SebastianGranolles AndrésFarfan FernandaSatagopam Venkata PTrenkwalder ClaudiaMollenhauer BritKrüger RejkoPoewe WernerTolosa EduardoMartí María-José - Pain significantly impairs quality of life in Parkinson's disease (PD). While the PD Pain Classification System (PD-PCS) categorizes PD-related pain into nociceptive, neuropathic, and nociplastic pain, the clinical and structural correlates of these subtypes, particularly nociplastic pain, remain poorly characterized. The objective of this study was to elucidate the distinct features of each PD-related pain subtype. - Source: PubMed
Publication date: 2026/07/27
Tezuka ToshikiNukariya TomonoriOkusa ShoheiUeda RyoSaegusa HirokiOkochi RyotaroSakai YutoNihei YoshihiroNakahara JinSeki Morinobu - The purpose of this study is to ascertain the incidence of fatigue and to determine the cross-sectional associate and related variables of fatigue in patients with Parkinson's disease (PD). - Source: PubMed
Publication date: 2026/07/15
Ning HaiboChen LeiWang MinLv NingChen Lihua - Sleep disturbances are highly prevalent among elderly patients with Parkinson disease (PD), substantially impairing their quality of life. This study aimed to identify associated risk factors and to develop and validate a nomogram risk prediction model based on multidimensional data, providing a practical tool for early clinical identification and intervention. A retrospective case-control study was conducted on 340 elderly PD patients admitted to a tertiary hospital between June 2023 and June 2025. Multidimensional data were collected through self-designed questionnaires, standardized clinical scales, and electronic medical records. Patients were classified into a sleep disorder group and a non-sleep disorder group using the second version of the Parkinson Disease Sleep Scale (PDSS-2) with a cutoff score of ≥18. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors, which were subsequently incorporated into the nomogram model. Model discrimination was assessed by the receiver operating characteristic (ROC) curve, while calibration was evaluated using bootstrap resampling and calibration plots. The prevalence of sleep disturbances in elderly hospitalized PD patients was 61.2%. Multivariate analysis identified advanced Hoehn-Yahr stage, higher UPDRS-II score, severe nocturnal pain, increased nocturia frequency, and elevated HADS-depression scores as independent predictors of sleep disturbances. The developed nomogram demonstrated good discriminative ability, with an area under the ROC curve (AUC) of 0.867, sensitivity of 0.884, and specificity of 0.765. The Hosmer-Lemeshow test indicated satisfactory model calibration. Sleep disturbances are common in elderly hospitalized PD patients and are influenced by multiple clinical factors. The proposed nomogram model exhibits favorable predictive performance and calibration, offering an effective clinical tool for risk stratification and facilitating early intervention. - Source: PubMed
Wu LinlinZhang LiWu Yanyan - Primary coenzyme Q10 (CoQ10) deficiency (PCOQ10D) is an autosomal recessive mitochondrial disorder caused by pathogenic variants in genes involved in the CoQ10 biosynthetic pathway, including PDSS2, COQ2, COQ6, and COQ8B/ADCK4. Among these, pathogenic variants in the COQ2 gene impair oxidative phosphorylation and mitochondrial biogenesis in podocytes, often leading to encephalopathy and nephropathy. - Source: PubMed
Yue YuqiZhao FeiChen Qiuxia