Ask about this productRelated genes to: PDHA1 antibody
- Gene:
- PDHA1 NIH gene
- Name:
- pyruvate dehydrogenase E1 alpha 1 subunit
- Previous symbol:
- PDHA
- Synonyms:
- -
- Chromosome:
- Xp22.12
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2017-08-08
Related products to: PDHA1 antibody
Related articles to: PDHA1 antibody
- Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with limited effective targeted therapies. Metabolic reprogramming is a hallmark of cancer, and post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and malonylation, play critical roles in regulating metabolic pathways. However, their contribution to metabolic reprogramming in CRC remains unclear. - Source: PubMed
Li TianyuanDong JingjingZhang YujieHao ErjiaoDU JieFeng MinZhu FengQin JuanZhang WeiDai Yong - Lesion mimic mutants (LMMs) spontaneously develop defense-related cell death lesions, serving as ideal models for studying plant immunity. However, the metabolic mechanisms underlying light-dependent lesion formation remain poorly understood. - Source: PubMed
Publication date: 2026/04/10
Chen ZiqiangKong LanLiu HuaqingLi GangTian DagangWang YueLin YarongYan JingwanGuo XinruiHu ChangquanYang Shaohua - Alzheimer's disease (AD) is characterized by progressive neurodegeneration and impaired glucose metabolism. While most studies focus on heavily affected brain regions such as the hippocampus and prefrontal cortex, the visual cortex remains relatively preserved in early AD and provides an opportunity to examine metabolic alterations that precede widespread pathology. - Source: PubMed
Publication date: 2026/04/09
Mjaaseth Ulrik NHsu Ming-FoArballo JosephHaj Fawaz GPatel Viharkumar - Pyruvate dehydrogenase complex (PDHc) deficiency is a potentially treatable neurodegenerative genetic disorder. It represents a common cause of mitochondrial disease. Most published reports are limited to single cases, and population-based data are lacking. The objective of this study was to investigate the prevalence, incidence, and life expectancy and to explore genotype-phenotype correlations, clinical onset, and disease course. - Source: PubMed
Publication date: 2026/04/14
Savvidou AntriSofou KalliopiThunström SofiaYgberg SofiaEklund Erik ANaess KarinKollberg GittanDarin Niklas - This study evaluates the protective effects of kaempferol on right ventricular (RV) structure and function in a rat model of high-altitude pulmonary hypertension (HAPH) and explores the underlying mechanisms. Male Sprague-Dawley rats ( = 57) were exposed to a simulated high-altitude environment (5000 m) for 28 days to induce HAPH, followed by the administration of kaempferol (25, 50, 100 mg kg day) or sildenafil (30 mg kg day). Echocardiography, hemodynamic measurements, and histopathological analyses revealed that kaempferol significantly reduced the RV/(LV + S) index, mean pulmonary artery pressure (mPAP), mean right ventricular systolic pressure (mRVSP), and RV free wall thickness (RVFWT); increased the pulmonary artery acceleration time (PAAT), PAAT/pulmonary artery ejection time (PAET) ratio, tricuspid annular plane systolic excursion (TAPSE), and RV-pulmonary artery coupling indices (TAPSE/mPAP and TAPSE/pulmonary artery systolic pressure [PASP]); and attenuated RV remodeling (assessed by H&E staining, Masson's trichrome staining, and transmission electron microscopy). Phosphoproteomic screening identified AMPK signaling as a key pathway modulated by kaempferol. , kaempferol downregulated the hypertrophy marker (MYH7B), suppressed the AMPK/ACC/CPT1B axis (at 25/50 mg kg), and reduced the LDHA (at 50/100 mg kg) and p-PDHA1 levels (at 25/50 mg kg) in RV tissues. Using the CCK-8 assay, fluorescence microscopy, and hypertrophy marker (BNP/MYH7B) detection, the optimal concentrations of Ang II (1 × 10 M) and kaempferol (40 μM) were selected. The effects of kaempferol on AMPK-mediated glucose and fatty acid oxidation were partially reversed by AICAR co-treatment, confirming the involvement of the AMPK pathway. Collectively, these findings demonstrate that kaempferol protects the RV structure and function and attenuates RV remodeling in HAPH rats, potentially through the modulation of the AMPK/ACC/CPT1B axis and the AMPK-mediated LDHA/PDHA1 pathway. - Source: PubMed
Publication date: 2026/04/14
Zhao QiongqiongSu ShanshanChen JuHuayu MeiduoNan XingmeiLi XiaopingLi ZhanqiangLu Dianxiang