Ask about this productRelated genes to: PDE10A antibody
- Gene:
- PDE10A NIH gene
- Name:
- phosphodiesterase 10A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6q27
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-30
- Date modifiied:
- 2016-10-05
Related products to: PDE10A antibody
Related articles to: PDE10A antibody
- Medial artery calcification is highly prevalent in patients with CKD and peripheral artery disease. It is strongly associated with higher cardiovascular morbidity and mortality. The second messengers cyclic nucleotides cAMP and cGMP play important regulatory roles in a variety of human diseases, which are controlled by distinct phosphodiesterase (PDE) isozymes. PDEs have proven to be highly effective drug targets for the treatment of various conditions. Their function and regulation in medial artery calcification, however, remain unknown. - Source: PubMed
Publication date: 2026/06/18
Jin YingXie YangzhouyunDavis SeanFlores Alyssa MWang Xue-LinGuzman Raul JCai Yujun - Schizophrenia is a complex neuropsychiatric disorder characterized by impairments in cognition, perception, and social behavior. Current antipsychotic medications primarily target dopaminergic signaling but often exhibit limited efficacy in treating negative and cognitive symptoms. Moreover, long-term antipsychotic therapy is frequently associated with clinically relevant adverse effects, including metabolic syndrome and extrapyramidal symptoms (EPS). Phosphodiesterase 10A (PDE10A) has emerged as a promising non-dopaminergic therapeutic target involved in regulating cyclic nucleotide signaling in the striatum. However, several synthetic PDE10A inhibitors have shown safety and tolerability limitations. This study therefore investigated the antipsychotic-like potential of the ethanol extract of Dracocephalum moldavica (EEDM) and its major flavone glycoside, tilianin, in an MK-801-induced schizophrenia-like mouse model and explored the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/06/06
Cho Ye EunPark Hyeon-BaeChelliah RamachandranKim So-YeonCho So-YoungLee Su-JungLee Ye-WonLee Seon-WooLee Na-HyunLiu Xiang-QianSon Seung HwanLee SanghyunRyu Jong HoonOh Deog HwanBae Ho JungPark Se Jin - Long-term outcome data for stiff person spectrum disorder (SPSD) remain limited and sustained response to treatment varies. - Source: PubMed
Mangioris GeorgiosMcKeon AndrewBower James HVorasoot NisaDubey DivyanshuFlanagan Eoin PPittock Sean JZekeridou Anastasia - Neural autoantibody testing is standard for patients with suspected autoimmune neurologic disorders. The number of neural antibodies has increased dramatically in the past 40 years, with over 50 disease-specific neural antibodies defined to date. The advent of immune-profiling assays such as protein array and phage immunoprecipitation sequencing (PhIP-Seq) has further expedited the rate of antibody discovery, with many recent targets identified using these methods. In this review, we discuss traditional and novel methods of antibody discovery, with an emphasis on the incorporation of protein array and PhIP-Seq into our antibody discovery approach. Advantages, limitations, and potential future uses of these platforms within the field of autoimmune neurology are also considered. - Source: PubMed
Publication date: 2026/05/18
Gilligan MichaelMcKeon Andrew - Psychiatric comorbidities are increasingly recognised in demyelinating diseases, yet their frequency and timing in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are not well defined. We aimed to characterise the spectrum and temporal pattern of psychiatric illness in MOGAD and compare to multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) with aquaporin-4 antibody (AQP4-IgG). - Source: PubMed
Publication date: 2026/04/09
Niederschweiberer MoritzBakir CicekVorasoot NisaCacciaguerra LauraTillema Jan-MendeltVilaseca AndreuThakolwiboon SmathornAboseif AlbertSyc-Mazurek Stephanie BRees William ABasso Michael RLopez-Chiriboga A SebastianWingerchuk Dean MTobin W OliverCroarkin Paul ESagen JessicaPittock Sean JChen John JFlanagan Eoin P