Ask about this productRelated genes to: NUBPL antibody
- Gene:
- NUBPL NIH gene
- Name:
- nucleotide binding protein like
- Previous symbol:
- C14orf127
- Synonyms:
- FLJ12660, IND1, huInd1
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-17
- Date modifiied:
- 2017-02-07
Related products to: NUBPL antibody
Related articles to: NUBPL antibody
- Epilepsy is a severe neurological disorder with complex pathogenesis. Mitochondrial dysfunction (MitD) is increasingly recognized as a key driver of epileptogenesis and seizure generation, contributing to neuronal hyperexcitability and network instability. However, the potential mechanisms linking MitD to epilepsy remain incompletely understood. This study aimed to identify MitD-related biomarkers in epilepsy and investigate their associations with alterations in the immune cell infiltration landscape during epileptogenesis. On the basis of the GSE47752 dataset, differential expression analysis was performed to identify differentially expressed genes (DEGs) between the control group and epilepsy groups in the early phase after status epilepticus (SE). The intersection of DEGs across time points yielded core DEGs, which were further intersected with MitD-related genes (MDRGs) to obtain MitD-related differentially expressed genes (MDR-DEGs). Multiple machine learning algorithms (LASSO, Boruta, XGBoost, and SVM-RFE) were applied to identify robust candidate biomarkers through consensus feature selection strategies, prioritizing genes with high stability across different algorithms. Importantly, immune infiltration was analyzed via the single-sample gene set enrichment analysis (ssGSEA) algorithm to characterize the immunological microenvironment in epilepsy. Finally, the expression of candidate biomarkers was validated via RT-qPCR in hippocampal tissues from a lithium-pilocarpine (Li-Pilo) rat model. Machine learning consensus pinpointed three candidate biomarkers: Idi1, Nubpl, and Tspo. Single-gene gene set enrichment analysis (GSEA) revealed that Nubpl and Tspo were significantly enriched in the complement and coagulation cascades pathway. Immune infiltration analysis revealed a substantial increase in the abundance of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). The expression of Nubpl and Tspo was strongly positively correlated with that of most of these differentially infiltrated immune cell subsets. RT-qPCR confirmed that Nubpl and Tspo mRNA levels were significantly elevated in the early phase post-SE compared with those in controls, whereas the change in Idi1 expression was not statistically significant. Nubpl and Tspo were identified as key candidate biomarkers associated with MitD in epilepsy. The candidate biomarkers may contribute to epileptogenesis not only through direct mitochondrial pathways but also through crosstalk between complement and coagulation cascades and immune cell dynamics. These findings offer novel insights into the integrative molecular and immunological mechanisms linking MitD to epilepsy, highlighting potential therapeutic targets. - Source: PubMed
Publication date: 2026/05/14
Wu ZhenghanPei HonglongHuang RongzhuHuang WenqiangXiong AnboDong ZhuoqiLi ShipengChen YuyunWang WeiYu HualinQi RenliLi Jinghui - Ewing's sarcoma (ES) is a malignant osseous neoplasm characterized by a dismal prognosis, particularly in its metastatic variant. The significance of disulfidptosis-a newly identified cell death mechanism induced by cystine metabolic imbalance and mitochondrial dysfunction-has yet to be investigated in ES. Thus, the aim of this study was to assess the prognostic significance of disulfidptosis-related genes (DRGs) in this disease. - Source: PubMed
Publication date: 2026/04/15
Wang ZhenyangChen YongqinYang YuxuanQi LeiXu BitengLi KeWang LiangJiao Xiejia - Serum antibody levels against microbial biomarkers of periodontitis, and , are associated especially with the presence of these species in the oral cavity. We investigated the genetic basis of host antibody responses against these species through a genome-wide association study (GWAS) to identify the genetic determinants of this immune reactivity. Serum immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody levels against and were determined using multiserotype enzyme-linked immunosorbent assay in 3,719 participants from 4 Finnish cohort studies: FinnTwin, Parogene, FINRISK97, and Health-2000. The associations of genetic polymorphisms and imputed human leukocyte antigen (HLA) alleles with antibody levels were investigated. All antibody levels presented significant increasing trends with periodontitis stage and grade. IgG displayed association with single nucleotide polymorphisms (SNPs) in chromosome 6 with lead SNP rs574581129 (near , = 3.6 × 10) and IgG in chromosome 14 with lead SNP rs146761521 (near , 5.5 × 10). In addition, all antibody levels presented suggestive associations with several loci. Detailed HLA analyses revealed that IgG was associated with DQA1*01:01, DQB1*05:01, and DRB1*01:01 and IgG with HLA-A*02:01 alleles. Both IgA and IgG antibody levels against microbial biomarker species of periodontitis increase with periodontitis stage and grade, but genetic variation is also a significant predictor. Specific alleles within the HLA region may influence antibody responses to and , highlighting potential genetic contributions to the immunological mechanisms underlying periodontitis. - Source: PubMed
Publication date: 2025/11/30
Abdelkader HSalminen ALeskelä JPalviainen TSalasuo EPaju SMäntylä PSuominen LKaprio JSalomaa VSinisalo JPussinen P J - Alzheimer's disease (AD) represents the most prevalent neurodegenerative disorder, with mitochondrial dysfunction being observed in both AD patients and mouse models. Nonetheless, further investigation is required to elucidate the pathogenic genes associated with AD and to develop early diagnostic methodologies centered on mitochondrial function. - Source: PubMed
Publication date: 2025/11/27
Zhu XuchaoZhang LingQin Chuan - Glioma, a common primary brain tumor arising from glial cells, presents significant therapeutic challenges due to its diverse and complex biological behavior. While disulfidptosis has recently emerged as a novel form of cell death, the role of disulfidptosis-related genes (DRGs) in glioma and their relationship with the tumor immune microenvironment remains poorly understood. - Source: PubMed
Publication date: 2025/09/26
Zhu JinchaoKe YaoFan YijuanLin QingyuanZhu WeiyaoGuo WenhuanNie Shengdong