Ask about this productRelated genes to: NSMCE2 antibody
- Gene:
- NSMCE2 NIH gene
- Name:
- NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
- Previous symbol:
- C8orf36
- Synonyms:
- FLJ32440, MMS21, NSE2, ZMIZ7
- Chromosome:
- 8q24.13
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-27
- Date modifiied:
- 2018-08-15
Related products to: NSMCE2 antibody
Related articles to: NSMCE2 antibody
- NSMCE2, a SUMO E3 ligase subunit of the SMC5/6 complex, is essential for maintaining genomic integrity during mitosis, yet its meiotic function remains poorly understood. Here, we investigated the physiological role of NSMCE2 in male germ cells using a conditional knockout mouse model. Despite its high and stage-specific expression in testes, germline deletion of resulted in no apparent impairment of spermatogenesis or fertility. Comprehensive analyses revealed normal testicular architecture, unaltered meiotic progression, intact DNA double-strand break repair, and stable transcriptomic profiles in -deficient testes. Mechanistically, we observed a specific upregulation of the SUMO E3 ligase PIAS1, which suggests a potential role in maintaining global SUMOylation homeostasis in the deficiency of NSMCE2. These findings demonstrate that NSMCE2 is dispensable for male fertility under physiological conditions. Such dispensability suggests that the meiotic DNA repair network possesses substantial functional redundancy and robust compensatory capacity, ensuring the maintenance of spermatogenic integrity even in the absence of a key repair factor. Collectively, our study highlights the resilient and fail-safe design of the mammalian meiotic system, which safeguards fertility through intrinsic robustness and molecular redundancy. - Source: PubMed
Publication date: 2026/03/03
Qin ZihanXiong QiaohuaWang MeiFang YuchenFan QigangMa BinyuGao YingCheng MuyangCao YumingZhang Yuanzhen - BACKGROUND: Reproductive efficiency is an important component of profitability and sustainability in beef cattle production, particularly in tropical environments where animals are routinely exposed to environmental stressors. This study aimed to identify environmentally sensitive SNPs associated with sexual precocity traits in Nellore cattle and characterize candidate genes and biological pathways regulating sexual precocity under variable environmental conditions. For this purpose, three sexual precocity indicators were analyzed; one in heifers (heifer early calving probability at 30 months, HC30), and two in young males (scrotal circumference at 365 days, SC365; age at puberty, APM). Reaction norm models were integrated with genome-wide association studies (GWASs) to identify genomic regions associated with both genetic potential (intercept) and environmental sensitivity (slope). RESULTS: A total of 46 significant SNPs were identified across the three traits, with SC365 showing the highest genetic complexity (36 SNPs), followed by HC30 (7 SNPs), and APM (3 SNPs). The analyses revealed distinct genetic architectures among the traits. For HC30, candidate genes showed clear functional partitioning between those associated with baseline fertility (e.g., ERBB4, SNAI2) and those associated with environmental sensitivity (e.g., TRIB1, NSMCE2), with no overlap between intercept and slope components. In contrast, SC365 exhibited substantial genetic overlap, with five genes (i.e., GRB14, SLC9A8, SPATA2, MGRN1, SEPTIN12) significantly associated with both intercept and slope, indicating a robust trait with shared genetic control of baseline potential and environmental responsiveness. For APM, genetic associations were predominantly related to baseline potential, with genes involved in DNA repair (CHEK2), endoplasmic reticulum stress response (XBP1), and immune regulation (TNIP3). Functional enrichment analyses revealed trait-specific biological pathways, whereas QTL enrichment demonstrated biologically coherent overlaps with reproductive and metabolic traits. CONCLUSION: These findings demonstrate that sexual precocity traits exhibit distinct genetic architectures reflecting their underlying biological mechanisms and environmental responsiveness, providing valuable insights for developing climate-resilient breeding strategies in tropical beef cattle production systems. - Source: PubMed
Publication date: 2026/01/21
da Silva Oliveira EduardaRojas de Oliveira HinayahMacedo Mota Lucio FlavioMulim Henrique AlbertoFerreira Campos Milena AparecidaBarbosa da Silva Neto JoãoBaldi Fernando - - Source: PubMed
Publication date: 2025/06/16
Watanabe Ryuta - N6-methyladenosine (mA) modification is a key mechanism to regulate the tumorigenesis of prostate cancer (PC). However, the function of Vir Like M6A Methyltransferase Associated (VIRMA), an mA writer, in PC remains further explored. Therefore, the objective of this study is to verify the function and mechanism of VIRMA in PC via non-SMC Element 2 (NSMCE2) and reactive oxygen species (ROS). - Source: PubMed
Publication date: 2025/06/03
Ma JinhuaQu Xi - Primary liver cancer is a malignant tumor of the digestive system and ranks as the sixth most commonly diagnosed cancer globally. It has also risen to become the third leading cause of cancer-related deaths globally, following lung and colorectal cancers. Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancer, approximately 75 to 85 %. Several studies suggest that NSMCE2 contributes to cancer through its SUMO E3 ligase activity, yet its specific role in HCC remains poorly understood. - Source: PubMed
Publication date: 2025/05/02
Chen YukaiZou ShishiXu LeChen JiayuWang LingShen YangXu YangtaoWei YuxinXu Ximing