Ask about this productRelated genes to: NOTCH1 antibody
- Gene:
- NOTCH1 NIH gene
- Name:
- notch receptor 1
- Previous symbol:
- TAN1
- Synonyms:
- -
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2019-04-23
Related products to: NOTCH1 antibody
Related articles to: NOTCH1 antibody
- Huan Le Ning Decoction is a traditional Chinese medicinal formula empirically used to alleviate perimenopausal emotional disturbances. Despite its clinical application, the neurobiological mechanisms remain unclear. - Source: PubMed
Publication date: 2026/09/04
Ma XianXu YujieBi YuYang LuLi YixuanSun YilinZhao LinShao YanfeiZhang Qin - T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive non-Hodgkin lymphoma derived from precursor T cells, characterized by rapid clinical progression and a high relapse rate, with a particularly unfavorable prognosis in adult patients. Accumulating evidence indicates that the NOTCH signaling pathway plays a central oncogenic role in the initiation and progression of T-LBL. Its sustained aberrant activation is driven by multiple layers of mechanisms, including NOTCH1 gene mutations or fusions, synergistic amplification through multiple oncogenic signaling cascades, and dysregulated epigenetic control. Aberrantly activated NOTCH signaling promotes tumor cell proliferation, suppresses apoptosis, and contributes to chemotherapy resistance and disease relapse. This review focuses on the mechanisms underlying aberrant NOTCH activation in T-LBL and summarizes the principal therapeutic strategies targeting this pathway, along with their limitations, aiming to provide a framework for deeper under-standing of the molecular pathogenesis of T-LBL and for the development of more precise targeted therapies. - Source: PubMed
Publication date: 2026/08/31
Li ZhexinZheng Guzhengyue - Areca nut chewing is a major risk factor for oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC), yet the molecular mechanisms underlying its carcinogenic effects remain incompletely integrated. This systematic review aimed to synthesize in vitro evidence on the molecular effects of areca nut extract and areca nut-derived alkaloids in human oral cancer cells. - Source: PubMed
Publication date: 2026/08/17
Ayna Visilmi Kaffah PutriTampubolon Irene AnastasiaWidowati KharinnaSarasati AndariAyuningtyas Nurina FebriyantiSurboyo Meircurius Dwi Condro - Gastric cancer (GC) remains a leading cause of cancer-related mortality, with progression driven largely by the tumor microenvironment (TME). Tumor-associated macrophages (TAMs), the most abundant immune cells in the GC stroma, drive immune evasion, angiogenesis, metastasis, and chemoresistance through polarization toward an M2-like phenotype. - Source: PubMed
Publication date: 2026/08/20
Zhuang XiaodongYang QiangHuang LiangjiuLiu RishengMa TingGuan LiwenZheng Yana - Particulate matter with an aerodynamic diameter ≤10 μm (PM10) is a major environmental pollutant implicated in chronic airway injury and remodeling. This study investigated the effects of chronic PM10 exposure on epithelial barrier integrity, cellular differentiation, surfactant expression, and inflammatory signaling in a human small airway epithelial air-liquid interface (ALI) model. - Source: PubMed
Publication date: 2026/09/04
Heo Mi HyeonSon Eun SukPark So YoungKo Ui WonPark Jeong-WoongJeong Sung HwanKyung Sun Young