Ask about this productRelated genes to: NDUFA7 antibody
- Gene:
- NDUFA7 NIH gene
- Name:
- NADH:ubiquinone oxidoreductase subunit A7
- Previous symbol:
- -
- Synonyms:
- B14.5a
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-15
- Date modifiied:
- 2015-11-20
Related products to: NDUFA7 antibody
Related articles to: NDUFA7 antibody
- Rhesus macaques (Macaca mulatta) are the most common non-human primates living in captivity. The use of rhesus macaques as model objects is determined, first of all, by their phylogenetic and physiological closeness to humans, and, as a consequence, the possibility of extrapolating the obtained results to humans. Currently, it is known that a number of biochemical changes occur under various physiological conditions, including at the transcriptomic level. The real-time polymerase chain reaction is a widely used universal method for gene expression analysis. Carrying out such studies always requires a preliminary selection of "housekeeping genes" (HKGs) - genes necessary for the implementation of basic functions in the cell and stably expressed in different cell types and under different conditions. At present, there are only two systematic studies on the search for HKGs in the rhesus macaque brain, and therefore in this work a search and systematization of HKGs for this species were carried out. As a result, two panels of promising HKGs for M. mulatta were formed: an extended panel, consisting of 56 genes, and a small panel, consisting of 8 genes: ARHGDIA, CYB5R1, NDUFA7, RRAGA, TTC1, UBA6, VPS72, and YWHAH. Both panels of potential HKGs do not have pseudogenes in macaques or humans, are characterized by stable and sufficient expression in the brain of rhesus macaques and can be used to analyze expression not only in the brain but also in peripheral blood. However, it should be noted that the data have not been experimentally verified and require verification in laboratory conditions. - Source: PubMed
Shulskaya M VAlieva A KhKumakov I RShadrina M ISlominsky P A - The rising incidence of clear cell renal cell carcinoma (ccRCC) with current treatments offering limited survival benefits and a poor prognosis. Mitochondrial abnormalities impact tumor immunity, progression, and metastasis, and the role of mitochondrial energy metabolism-related genes (MMRGs) in ccRCC remains largely unexplored. This study analyzed TCGA-KIRC, GSE159115, and GSE29609 datasets to identify differentially expressed (DE) MMRGs and their functions. It used LASSO and Cox models to select prognostic MMRGs for model building, created a nomogram (based on independent factors) in TCGA-KIRC (evaluated via calibration and ROC curves), and conducted GSEA, immune cell correlation analyses, TF-miRNA-mRNA network studies, qRT-PCR (ccRCC vs. controls), and WB (RIPA) for biomarker validation. A study of 103 DE-MMRGs highlighted their link to fatty acid metabolism and peroxisome proliferator-activated receptor (PPAR) signaling. Machine learning assessed the prognostic potential of these DE-MMRGs, which yielded a risk model based on six key biomarkers. The constructed prognostic model exhibited outstanding performance in both training and validation sets. This study also explored immune cell relevance and regulatory networks and elucidated complex mitochondrial-tumor interactions. The validation of predictive biomarker expression in clinical samples underscored their role in refining prognostic assessment and therapeutic strategies for ccRCC. In this study, six mitochondrial energy metabolism-related prognosis biomarkers (COX7B, PPARGC1B, NDUFA11, PFKFB4, NDUFV2, and NDUFA7) were screened. A risk model was developed to provide a new reference for the prognosis of ccRCC patients. - Source: PubMed
Publication date: 2025/12/09
Peng YinqiZhang DahaoWang ShuangyuHuang FuHuang Haipeng - Alzheimer's disease (AD) is a common neurodegenerative condition involving a complex blend of disturbances in synaptic development and maintenance, neurovascular cross-talk, ionic and nutrient transport, and mitochondrial metabolism. The precise molecular profile of AD onset with insight for major pathological contributors remains unclear with corresponding impedances in therapeutic development. The current study sought two objectives, as (i) to resolve the molecular pathogenesis from cognitive impairment to the onset of AD-like neuropathology and (ii) whether the novel agent cannabidiol (CBD), noted for its neuroprotective effects, influences the molecular transition associated with AD onset. - Source: PubMed
Publication date: 2025/09/05
Bishara Mary AChum Phoebe PMiot Fritz E LHooda AnkitaHartman Richard EBehringer Erik J - Accurate, non-invasive assessment of liver fibrosis (LF) remains a clinical challenge. This study aimed to develop a MRI-based radiomic risk score (Radscore) for staging LF and to explore the biological relevance of radiomic features using transcriptomic analysis. - Source: PubMed
Publication date: 2025/06/26
Li FangyanLiang YaoXia XingWen YongTang MaowenHuang ZhaoshuHu NaLuo PengLei Pinggui - The hepatopancreas of plays a crucial role in metabolism and immune response, encompassing vital physiological functions. In our study, we established a hepatopancreatic injury model using thioacetamide (TAA) and evaluated the therapeutic potential of a commercial astaxanthin-based product (AST-product) on hepatopancreatic health. The experimental framework included a control group (Con), an injury model group (M), and a treatment group (T), enabling a comprehensive analysis of the effects of treatments on hepatopancreatic biochemical markers, tissue architecture, gene expression, and metabolic pathways. The biochemical results indicated significant oxidative damage and fibrosis in the M group post-TAA treatment, evidenced by increased malondialdehyde (MDA) levels, decreased superoxide dismutase (SOD) activity, and the disruption of tubular structures. Conversely, treatment with the AST-product significantly reduced MDA levels and ameliorated oxidative stress. Histological evaluations using hematoxylin and eosin (HE) and Sirius Red staining confirmed that the AST-product preserved tubular integrity and inhibited fibrosis progression. Metabolomic profiling revealed that the AST-product modulated key metabolic pathways, including arginine and proline metabolism, porphyrin metabolism, and nucleotide metabolism, which are critical for maintaining energy supply and antioxidative capabilities. This modulation mitigated the TAA-induced oxidative damage. Moreover, qPCR analysis demonstrated that the AST-product downregulated the pro-apoptotic gene CASP2, upregulated the energy metabolism-related gene NDUFA7, and enhanced the expression of the immune-related gene lysozyme, thereby boosting pathogen resistance. These findings elucidate the robust protective effects of the AST-product on hepatopancreatic health in , highlighting its potential to reduce oxidative stress, inhibit fibrosis, and enhance immune responses. This study provides a novel strategy for improving health in aquaculture and contributes valuable insights into hepatopancreatic protection and disease prevention in shrimp farming. - Source: PubMed
Publication date: 2025/05/24
He JiawenJu JianJiang QingliangZhao HaiyongZhang YingyingYang Hui