Ask about this productRelated genes to: MTMR14 antibody
- Gene:
- MTMR14 NIH gene
- Name:
- myotubularin related protein 14
- Previous symbol:
- C3orf29
- Synonyms:
- FLJ22405, FLJ90311, hJumpy, hEDTP
- Chromosome:
- 3p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-22
- Date modifiied:
- 2016-10-05
Related products to: MTMR14 antibody
Related articles to: MTMR14 antibody
- Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells which is critical for the elimination of cellular damage. Its capacity progressively declines with age, and this change can lead to the development of various neurodegenerative pathologies including Spinocerebellar ataxia type 1 (SCA1). SCA1 is mainly caused by mutations in the polyglutamine region of Ataxin 1 protein. In patients affected by the disease, Purkinje neurons of the cerebellum frequently undergo demise and eventually become lost. Here we tested whether two well-characterized autophagy-enhancing small molecules, AUTEN-67 and -99, which antagonize the autophagy complex Vps34 through blocking the myotubularin-related lipid phosphatase MTMR14/EDTP, have the capacity to ameliorate SCA1 symptoms. We found that in a model of SCA1, only AUTEN-67 exerts positive effects including improvement in climbing ability and extending life span. Based on these results, we hypothesized that the two compounds influence autophagy in the brain in a neuron-specific manner. Indeed, according to data we obtained, AUTEN-67 and -99 exhibit shared and unique functional domains in the brain. AUTENs enhance autophagy in GABAergic and dopaminergic neurons. In addition, AUTEN-67 also affect autophagy in cholinergic neurons, while AUTEN-99 trigger the process in glutaminergic neurons and motoneurons. We also observed varying efficiencies between the two AUTENs among different subtypes of cultured hippocampal neurons of mice. These data suggest that the two compounds display neuron-specific differences in exerting autophagy-enhancing effects, and may lead to a better understanding of which types of neurons autophagy could potentially be activated to treat SCA1 in human patients. - Source: PubMed
Publication date: 2025/10/27
Burján TímeaAslam MaryamKeresztes FanniSigmond TímeaBilles Viktor ABencsik NorbertSchlett KatalinVellai TiborKovács Tibor - Chronic obstructive pulmonary disease (COPD) is typically characterized by chronic airway inflammation and emphysema. Macrophage polarization plays an important role in COPD, while the precise molecules and mechanisms underpinning it have yet to be fully elucidated. Pulmonary decrease of myotubularin-related protein 14 (MTMR14) expression conduces to the progression of COPD in our prior publication, while the further analysis reveals the differential expression of MTMR14 in alveolar macrophages, whose function and related mechanisms are worth further research. Our study aims to investigate the role and mechanism of MTMR14 in macrophages of COPD. - Source: PubMed
Publication date: 2025/07/10
Zhang JiahengZhan YuanDeng ZhesongChen ShanshanYang RuonanZhang YatingFu HaoHuang QianWu JixingGu YiyaXie Jungang - Existing observational studies examining the effect of body fat on the risk of Parkinson disease (PD) have yielded inconsistent results. We aimed to investigate this causal relationship at the genetic level. - Source: PubMed
Zhao QianLiu DongmingBaranova AnchaCao HongbaoZhang Fuquan - The meat production traits of pigs are influenced by the expression regulation of multiple gene types, including mRNAs, miRNAs, and lncRNAs. To study the differences in meat production traits at the transcriptional level among individuals with different growth rates, the samples from eight Duroc × Bama Xiang F2 crossbred pigs with a fast growth rate (high gTroup) or a slow growth rate (low group) were selected to perform whole transcriptome sequencing and ceRNA regulatory network construction. This study first analyzed the differences in physiological and biochemical indicators, muscle histological characteristics, and muscle fiber types. A total of 248 mRNAs, 25 miRNAs, and 432 lncRNAs were identified as differentially expressed by whole transcriptome sequencing. Key genes that may influence meat production traits include , , , , , and . The ceRNA regulatory network map showed that ENSSSCG00000042061-ssc-mir-208b-, ENSSSCG00000042223-ssc-mir-146a-, ENSSSCG00000045539-ssc-mir-9-3-, and ENSSSCG00000047852-ssc-mir-103-1- may be the key factors affecting meat production traits through their regulatory relationships. This study provides valuable insights into the molecular mechanisms underlying porcine muscle development and can aid in improving meat production traits. - Source: PubMed
Publication date: 2024/08/14
Xu YupeiWang HuiCheng FengChen KuirongLei GuofengDeng ZhongrongWu XiaoxiaoLiu CongSi JingleiLiang Jing - Cervical cancer (CC) is the most common gynecological malignant tumor and the fourth leading cause of cancer-related death in women. The progression of CC is significantly affected by autophagy. Our objective was to use bioinformatics analysis to explore the expression, prognostic significance, and immune infiltration of autophagy-related genes in CC. - Source: PubMed
Li ShuzhenGao KunYao Desheng