Ask about this productRelated genes to: MOBKL2B antibody
- Gene:
- MOB3B NIH gene
- Name:
- MOB kinase activator 3B
- Previous symbol:
- MOBKL2B, C9orf35
- Synonyms:
- MOB1D, FLJ13204
- Chromosome:
- 9p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-11
- Date modifiied:
- 2016-10-05
Related products to: MOBKL2B antibody
Related articles to: MOBKL2B antibody
- Breast cancer is the most prevalent malignant tumor in women globally, with its prognosis linked to immune responses, especially CD8 + and CD4 + T cell infiltration. T cell exhaustion, an immune dysfunction seen in chronic infections and cancers, is not well understood in breast cancer. This study seeks to investigate the role and prognostic significance of genes related to T cell exhaustion in breast cancer through bioinformatics, offering insights into the mechanisms of T cell exhaustion in this disease. - Source: PubMed
Publication date: 2026/06/29
Guo LianheChen XiangjinZhou Fan - The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. - Source: PubMed
Publication date: 2026/06/16
D'Mellow MatthewWang HuanweiPalmer Jane MHemminki KariCebulla Colleen MBeasley Aaron BBechrakis Nikolaos EPritchard Antonia LWadt Karin WJohansson Peter AMobuchon LenhaBarlow SamanthaBrooks KellyBeckman TimothyOlsen Catherine MWarrier Sunil KByrne LindseyKalirai HelenMustard ColetteIngold NathanFörsti AstaIsaacs TimothyJayasinghe G J M Shanika RGlasson William JWilliamson GayleMcGrath Lindsay ALe Ngoc-QuynhChadha VikasGray Elin SBrown Kevin MCauchi PaulThomsen HaukeConnolly JulieMacGregor StuartWhiteman David CKiilgaard Jens FStern Marc-HenriCoupland Sarah EAbdel-Rahman Mohamed HZeschnigk MichaelHayward NickLaw Matthew H - Type I interferons (IFNs) play essential roles in antiviral immune responses. The extensive diversification of type I IFNs into various subtypes and duplicated gene copies has posed significant challenges for evolutionary reconstruction. To address this, we developed the type I IFN sequence composition and structure (IFN-SCOPE) model and gene-network graph degree centrality (GENE-GRADE) algorithm, which transform the discovery of type I IFN evolutionary trajectories into computing the node centrality in its gene networks. Through synteny-guided analysis, we verified that three previously reported evolutionarily conserved type I IFN loci (HACD4, MOB3B, and UBAP2) have maintained chromosomal colocalization across all major amniote lineages. While the MOB3B locus maintained a single IFN-κ ortholog, the HACD4 (IFN-HA) and UBAP2 (IFN-UB) loci showed lineage-specific expansion patterns: IFN-HA proliferated in mammals/reptiles but remained single-copy in birds, whereas IFN-UB expanded in birds but not in other lineages. A phylogenetic analysis revealed that these independently evolved multicopy genes nevertheless clustered into two conserved subgroups (IFN-HA2/HA1 and IFN-UB2/UB1), suggesting convergent functional specialization. Within the IFN-HA and IFN-UB clusters, the single-copy IFN-HA2 and IFN-UB2 genes, positioned at the ancestral ends of their respective genomic arrays, likely represent the progenitor sequences of each locus, where the poorly characterized IFN-ν (rather than IFN-β) is the ancestral form of mammalian IFN-HA subtypes. Furthermore, wet lab evidence revealed type I IFN genes at noncanonical loci resulting from interchromosomal duplication events in tortoises and diving ducks and provided clear evidence that interchromosomal duplications contributed to type I IFN gene diversity. These discoveries advance our understanding of the evolutionary mechanisms that shape type I IFN genes in amniotes and are potentially beneficial for the development of novel type I IFN-based antiviral treatments through comparative immunological approaches. - Source: PubMed
Publication date: 2026/05/14
Zhang LeMa FuboLiu JinpengYu YangchaoMa JunxiaoZhang LeiLi BingLi ChaofanLi KangLiu PengZhang Liguo - To map the disease locus for familial ocular melanosis (OM) in the Cairn Terrier. - Source: PubMed
Publication date: 2024/10/24
Winkler Paige ADawson-Baglien Ethan MCoffey Madeline CVenta Patrick JEkenstedt Kari JPetersen-Jones Simon M - Monopolar spindle-binding protein 3B (MOB3B) functions as a signal transducer and altered MOB3B expression is associated with the development of human cancers. - Source: PubMed
Sun JuanZhang Jin-XiuLi Meng-ShiQin Meng-BinCheng Ruo-XiWu Qing-RuChen Qiu-LingYang DanLiao CunLiu Shi-QuanHuang Jie-An