Ask about this productRelated genes to: MIOX antibody
- Gene:
- MIOX NIH gene
- Name:
- myo-inositol oxygenase
- Previous symbol:
- ALDRL6
- Synonyms:
- -
- Chromosome:
- 22q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-06
- Date modifiied:
- 2018-03-06
Related products to: MIOX antibody
Related articles to: MIOX antibody
- The disinfectant action of the mixed oxidants (MIOXs) was compared with that of sodium and calcium hypochlorite (NaClO and Ca(ClO)) in the post-treatment of anaerobic effluent. The following responses were evaluated: microbiological reduction (total coliforms and Escherichia coli); disinfection byproducts formation (total trihalomethanes-THM, i.e., the sum of chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM); and changes in physicochemical parameters: pH, temperature, redox potential, conductivity, chemical oxygen demand, ammonia nitrogen (N-NH) and ions: sodium, calcium, magnesium, potassium, chloride, chlorate, chlorite, nitrite, nitrate, sulfate, and phosphate. The experiment was conducted using a jar test system for 20 min at 100 rpm with a dosage of 2 mg of Cl·L. Microbiological results indicated greater efficiency in the removal of total coliforms for MIOX, with results showing a log reduction from 6.23 log MPN per 100 mL to 1.68 ± 0.13, 1.94 ± 0.08, and 2.53 ± 0.39 log MPN per 100 mL for Ca(ClO), NaClO, and MIOX, respectively. THM formation was predominantly TCM, with levels below the limit of detection for DBCM, BDCM, or TBM. The increases in electrical conductivity stood out among the physicochemical parameters, being more pronounced for MIOX. This result suggested that MIOX may have promoted greater ionic transport in the aqueous matrix, thereby enhancing disinfection. MIOX also demonstrated greater efficiency in oxidizing nitrogen compounds. This study suggests that mixed oxidants can exert a combined effect on the removal of nitrogen compounds, thereby improving the treatment of anaerobic wastewater containing N-NH. - Source: PubMed
Publication date: 2026/08/03
Abreu Neto Alfredo QuirinoMarinho TalitaKato Mario TakayukiFlorencio Lourdinha - D-Glucaric acid (GA) is an important platform chemical with wide applications in material, food, and pharmaceutical industries. GA production by separation and purification from plants is not applicable at large scale. Instead, there are three ways to produce GA: chemical, enzymatic, and microbial synthesis. This chapter introduces the research progresses in chemical, enzymatic, and microbial synthesis of GA, especially the latter two featuring the concept of green biomanufacturing. The key rate-limiting factors, both for enzymatic and microbial production of GA from sugars, are the supply of myo-inositol and the catalytical performance of myo-inositol oxygenase (MIOX). These are pivotal engineering targets to improve the production titers, rates, and yields of GA. In the broader context of global warming and carbon neutrality, cheaper renewables such as lignocellulose and even CO could be used as abundant carbon sources to produce GA in a more environmentally friendly manner. At last, we envision that the future of GA biomanufacturing and its industrial applications is bright, encouraged by the entrepreneurial successes exemplified by Kalion, Inc. - Source: PubMed
Publication date: 2026/07/30
Fang HaoZeng Anping - NR5A2 is a key regulator of zygotic genome activation (ZGA), which primarily takes place at the 4-8-cell stage in porcine embryos; however, its associated metabolic programs remain largely uncharacterized. In this study, single-blastomere RNA sequencing was performed using Smart-seq2 in 8-cell-stage porcine embryos derived from in vitro fertilization (IVF) or somatic cell nuclear transfer (SCNT). Based on the bimodal expression pattern of NR5A2, individual blastomeres were categorized into NR5A2-active and NR5A2-inactive groups. Differential expression analysis identified 46 differentially expressed genes (DEGs) in IVF embryos, which were mainly enriched in steroid hormone and lipid metabolism. In SCNT embryos, the top-ranked DEGs were functionally associated with mitochondrial respiration and ribosome biogenesis. A total of 14 NR5A2-associated DEGs were consistently identified in both embryo types and clustered into three core metabolic modules: glycolysis and energy metabolism (represented by HK2), lipid and steroid metabolism (including STAR, LIPG, PLCD1 and DLC1), and inositol metabolism (represented by MIOX). Single-blastomere qRT-PCR in parthenogenetic embryos further validated the bimodal expression of NR5A2, HK2, STAR and MIOX. Collectively, this study reveals an NR5A2-associated metabolic transcriptional signature in blastomeres of both IVF and SCNT embryos. These findings identify candidate metabolic genes that may inform future optimization of in vitro culture media to enhance the developmental competence of porcine embryos and warrant subsequent functional validation. - Source: PubMed
Publication date: 2026/07/23
Li ZihanXie FuhengHe YuqingMa LiLiang ShuangLiu Qiang - Qilian sheep are an important indigenous Tibetan sheep breed adapted to cold and hypoxic environments. To explore hepatic nutrient metabolism in Qilian sheep, this study compared liver transcriptomic profiles between Qilian sheep and Oula sheep raised under similar natural grazing and management conditions. Six 10-month-old ewes from each breed were selected, and three high-quality liver RNA samples from each group were used for transcriptome sequencing. A total of 1640 differentially expressed genes were identified using the thresholds of |log2FoldChange| > 1 and false discovery rate < 0.05, including 922 upregulated and 718 downregulated genes in Qilian sheep compared with Oula sheep. KEGG enrichment analysis showed that these genes were mainly associated with lipid metabolism, amino acid metabolism, the PPAR signaling pathway, fatty acid biosynthesis, and fatty acid β-oxidation. qRT-PCR validation confirmed the differential expression of 11 candidate genes, including , , , , , , , , , , and . These results suggest that Qilian sheep and Oula sheep differ in hepatic gene expression patterns related to lipid utilization, amino acid metabolism, and energy regulation, providing candidate genes and pathways for understanding breed-associated hepatic metabolic characteristics. - Source: PubMed
Publication date: 2026/05/15
Ren YaxiongAn Qi-TalaDu XiaohuaLiu XiaGao FanhongLi YuanXu YingYao LiangweiLi Wenhao - Melon (.) is a widely cultivated fruit globally, valued for its high nutritional content and diverse culinary uses. However, the molecular mechanisms underlying flavor enhancement mediated by grafting remain poorly understood. - Source: PubMed
Publication date: 2026/05/01
Zhang HaoMuhammad Mohsin KaleemLiang QiganDu YinkeMaerhaba PaerhatiTian BanlvZhang HaojieZhang WenweiHuang YuanWang MinZhu JingrongFu Xiaofa