Ask about this productRelated genes to: METTL21A antibody
- Gene:
- METTL21A NIH gene
- Name:
- methyltransferase like 21A
- Previous symbol:
- FAM119A
- Synonyms:
- LOC151194, HCA557b, HSPA-KMT
- Chromosome:
- 2q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-05-15
- Date modifiied:
- 2015-11-09
Related products to: METTL21A antibody
Related articles to: METTL21A antibody
- Methyltransferases (MTases) play central roles in numerous biological processes and have emerged as attractive therapeutic targets in a wide range of diseases. METTL21A is a protein lysine MTase responsible for the trimethylation of HSP70 family members. Moreover, METTL21A is overexpressed in hepatocellular carcinoma (HCC), where overexpression correlates with poor clinical outcome. Despite its biological and clinical relevance, small-molecule inhibitors of METTL21A remain largely unexplored. Here, we report the identification of 6d as a METTL21A inhibitor and the subsequent structure-activity relationship (SAR) study of analogues decorated with various fluorinated substituents, leading to metabolically stable 6n (HK262) with an IC 1.10 μM. We solved a crystal structure of METTL21A in complex with 6m (HK474), providing structural insight into ligand recognition and supporting further structure-guided optimization. These findings establish a biochemically and structurally validated starting point for probing METTL21A function and a foundation for the development of cellularly active METTL21A-targeted chemical tools. - Source: PubMed
Publication date: 2026/08/11
Kocek HugoVaško MichalDejmek MilanProcházková EliškaŠála MichalJanovská AnnaMatoušová MarikaDvořáková AlexandraBoura EvzenNencka Radim - Protein methyltransferases regulate diverse physiological and pathological processes through histone and non-histone substrate methylation. While the role of histone methyltransferases in tumorigenesis is well-established, the contribution of non-histone methyltransferases, particularly Methyltransferase 21A (METTL21A), to hepatocellular carcinoma (HCC) progression remains poorly characterized. Here, we report that METTL21A is significantly upregulated in HCC tissues and associated with poor clinical prognosis. Transcriptional activation by CCCTC-binding factor (CTCF) was identified as a key driver of METTL21A overexpression. Functional studies demonstrated that METTL21A promotes HCC growth and metastasis in both in vitro and in vivo models. Mechanistically, METTL21A mediates methylation of Bcl-2-associated athanogene-3 (BAG3), thereby inhibiting its ubiquitination and subsequent degradation. We further identified Tripartite motif containing 21 (TRIM21) as the E3 ligase responsible for BAG3 ubiquitination and found that METTL21A disrupts the TRIM21-BAG3 interaction. Notably, we discovered that the natural compound sophoricoside (Sop) acts as a METTL21A inhibitor and exhibits potent anti-HCC activity. Our study not only elucidates the oncogenic role and molecular mechanism of METTL21A in HCC progression but also highlights its therapeutic potential as a novel drug target for HCC treatment. - Source: PubMed
Publication date: 2025/07/10
Zhan PingCheng YizheWu YingcanLu JingWen JingChi XiaoqinLuo ChanghongPeng YiweiChen XijunWang FuqiangYin ZhenyuXie Chengrong - Varicose veins (VV) are one of the common human diseases, but the role of genetics in its development is not fully understood. - Source: PubMed
Publication date: 2024/07/09
Zhang Dan-DanHe Xiao-YuYang LiuWu Bang-ShengFu YanLiu Wei-ShiGuo YuFei Chen-JieKang Ju-JiaoFeng Jian-FengCheng WeiTan LanYu Jin-Tai - Intracranial aneurysms (IAs) represent protrusions in the vascular wall, with their growth and wall thinning influenced by various factors. These processes can culminate in the rupture of the aneurysm, leading to subarachnoid hemorrhage (SAH). Unfortunately, over half of the patients prove unable to withstand SAH, succumbing to adverse outcomes despite intensive therapeutic interventions, even in premier medical facilities. This study seeks to discern the pivotal microRNAs (miRNAs) and genes associated with the formation and progression of IAs. - Source: PubMed
Publication date: 2024/01/09
Xu DongxiaoGareev IlgizBeylerli OzalPavlov ValentinLe HuangShi Huaizhang - Currently, 80%-90% of liver cancers are hepatocellular carcinomas (HCC). HCC patients develop insidiously and have an inferior prognosis. The methyltransferase-like (METTL) family principal members are strongly associated with epigenetic and tumor progression. The present study mainly analyzed the value of METTLs (METTL1/13/18/21A/23/25/2A/2B/5/6/9) and associated mRNA risk signature for HCC. METTLs expression is upregulated in HCC and is a poor prognostic factor in HCC. METTLs were upregulated in patients older than 60 and associated with grade. Except for METTL25, the remaining 10 genes were associated with the HCC stage, invasion depth (). In addition, METTLs showed an overall alteration rate of 50%. Except for METTL13/2A/25/9, the expression of the other seven genes was significantly associated with overall survival, disease-specific survival, and progression-free survival. Multivariate studies have shown that METTL21A/6 can be an independent prognostic marker in HCC. A total of 664 mRNAs were selected based on Pearson correlation coefficient ( > 0.5), unsupervised consensus clustering, weighted coexpression network analysis, and univariate Cox analysis. These mRNAs were significantly associated with METTLs and were poor prognostic factors in HCC patients. The least absolute shrinkage and selection operator (lasso) was used to construct the best METTLs associated with mRNA risk signature. The mRNA risk signature was significantly associated with age, stage, and grade. The mRNA high-risk group had higher TP53 and RB1 mutations. This study constructed a nomogram with the mRNA risk profile and clinicopathological features, which could better predict the OS of individuals with HCC. We also analyzed associations between METTLs and mRNA risk signatures in epithelial-mesenchymal transition, immune checkpoints, immune cell infiltration, tumor mutational burden, microsatellite instability, cancer stem cells, tumor pathways, and drug sensitivity. In addition, this study constructed a protein interaction network network including METTLs and mRNA risk signature genes related to tumor microenvironment remodeling based on single-cell sequencing. In conclusion, this study provides a theoretical basis for the mechanism, biomarker screening, and treatment of HCC. - Source: PubMed
Publication date: 2023/10/12
Wang HaoyuHu ShangshangNie JunjieQin XiaodanZhang XuWang QianLi John Zhong