Ask about this productRelated genes to: MAPK1 antibody
- Gene:
- MAPK1 NIH gene
- Name:
- mitogen-activated protein kinase 1
- Previous symbol:
- PRKM2, PRKM1
- Synonyms:
- ERK, ERK2, p41mapk, MAPK2
- Chromosome:
- 22q11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-05
- Date modifiied:
- 2019-04-23
Related products to: MAPK1 antibody
Related articles to: MAPK1 antibody
- Adverse outcome pathways (AOPs) describe stressor non-specific sequences of events between a first molecular trigger (molecular initiating event, MIE), causally linked key events (KEs), and an adverse outcome (AO). AOPs are intended to aid in chemical toxicity testing as a new approach methodology. However, commonly used AOP development methods depend on manual curation, which is labor intensive. As a result, there are still relatively few AOPs and a huge number of toxicity mechanisms and possible adverse outcomes remain undescribed. Therefore, systematic and high-throughput approaches to predict new AOPs are needed. Here, we developed and implemented a data integration-based framework to generate new candidate AOPs using insecticides and Parkinson Disease as a proof of concept. We integrated and statistically linked disconnected databases (e.g., Comparative Toxicogenomics Database, Human Protein Atlas, and Gene Ontology) to form MIE - KE (cell level) - KE (tissue level) - AO candidate AOPs. Through this systematic process, we generated 562,117 candidate AOPs, which we then scored using a weight of evidence (WoE) approach and prioritized 12,756 AOPs with a WoE >0.5. The prioritized AOPs describe varied mechanisms of toxicity related to e.g., MAPK, PTEN, and FGFR signaling pathways, with "increases phosphorylation of MAPK1" as the most frequent MIE. Through analysis of 100 random prioritized AOPs, we found 70% had external literature supporting their biological plausibility, and only 15% represented identifiably implausible associations. Our AOP generating approach yields consistently structured AOPs and can complement existing and emerging development methods to expand AOP coverage across different stressors and outcomes. - Source: PubMed
Publication date: 2026/09/10
Rollin DorianShen ChenyuGroh KseniaKosnik Marissa B - Insulin resistance is a common metabolic feature of metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes (T2D), but its cross-sectional association with the coexistence of these conditions remains incompletely characterized. - Source: PubMed
Publication date: 2026/09/08
Heng Xian-PeiYang Liu-QingChen Qi-WeiJin Lin-XiLi Yu-WanRuan YiHan ZhuangYao Shu-HongHong Xin-MiaoWang Zhi-TaLi LiangHe Wei-Dong - Ochratoxin A (OTA) is a persistent foodborne environmental contaminant with recognized systemic toxicity, but the molecular basis of its reproductive effects remains incompletely defined. We integrated network toxicology, molecular docking, molecular dynamics simulation and public single-cell RNA sequencing to generate candidate mechanisms, and then evaluated selected predictions using cell-viability and transcript-level assays. Intersections between OTA-related and reproductive-injury targets yielded 318 testicular and 426 ovarian candidate targets. AKT1, MAPK1, PIK3CA, SRC and TP53 were shared network hubs, while enrichment analysis prioritized PI3K-Akt signaling, apoptosis, p53, FoxO and MAPK pathways. Docking predicted favorable OTA poses for the five hub proteins, and 100-ns simulations of the selected AKT1-OTA and PIK3CA-OTA complexes showed persistence of the predicted poses within the modeled systems; these computational findings do not establish biological binding or direct target engagement. Public single-cell data localized the candidate genes to germ, somatic and steroidogenic cell populations. In vitro, OTA reduced 24-h viability with IC50 values of 9.25 micromolar in GC-1 cells and 27.94 micromolar in KGN cells and altered hub-gene transcripts. Taken together, the results suggest that OTA-associated reproductive cell stress may involve PI3K-Akt-related survival signaling and apoptosis-linked responses, but protein-level and functional validation is required. - Source: PubMed
Publication date: 2026/09/09
Xu YingkunHua RuiZhang PeizhiYu HanpuQiu Jiechuan - Ionizing radiation (IR) generates reactive oxygen species (ROS), resulting in oxidative imbalance and tissue injury. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway regulates antioxidant gene expression; however, effective radiomodulatory agents remain limited. Resveratrol (RES), a natural antioxidant with anti-inflammatory and ROS-scavenging properties, has been proposed as a potential radioprotective compound. - Source: PubMed
Publication date: 2026/09/09
Fekry Hader OAbdelrahman Ibrahim YSoliman Saeed MAbdelkader Nour MEl-Sayed Wael M - The escalating prevalence of obesity has made it a critical public health concern. There is an urgent need to identify naturally derived compounds with anti-obesity potential. Britanin (BRI), a bioactive sesquiterpene lactone derived from Inula species, has shown promise in metabolic disorder management, but its anti-obesity mechanisms remain uncharacterized. - Source: PubMed
Zhang YiQingWu ZhiKangLi XianJiang HeZiZhou XinYuShen JinShengWang XiangyuZhang GuoXingZhou Yafeng