Ask about this productRelated genes to: MAPK1 antibody
- Gene:
- MAPK1 NIH gene
- Name:
- mitogen-activated protein kinase 1
- Previous symbol:
- PRKM2, PRKM1
- Synonyms:
- ERK, ERK2, p41mapk, MAPK2
- Chromosome:
- 22q11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-05
- Date modifiied:
- 2019-04-23
Related products to: MAPK1 antibody
Related articles to: MAPK1 antibody
- Although the molecular mechanism by which wortmannin exerts its anticancer properties in solid tumors is not fully understood, particularly in the context of oral cancer where research is scarce, this study seeks to explore how wortmannin disrupts the PI3K pathway, consequently affecting the proliferation and apoptosis of human oral cancer cells. - Source: PubMed
Kumbhar GauriSuryawanshi PoonamLadke Vaibhav - This study integrated network pharmacology and experimental validation to elucidate the mechanism of Longdan Xiegan Pills (LDXG) in treating chronic stress-induced hypertension. Active components of LDXG were retrieved from the TCMSP database and screened based on oral bioavailability (OB) and drug-likeness (DL). Potential targets were predicted using SwissTargetPrediction. Disease targets related to hypertension were collected from OMIM and GeneCards. A compound-target network was constructed using Cytoscape, and protein-protein interaction (PPI) analysis was performed via the STRING database. Functional enrichment analysis (GO and KEGG) was conducted using DAVID. Molecular docking was performed with LeDock. In vivo, systolic and diastolic blood pressures were measured non-invasively, myocardial histopathology was evaluated by HE staining, the content of target protein in pvn and adrenal gland was measured by western blot, and serum inflammatory markers were quantified via ELISA. A total of 178 active components of LDXG were screened, Gentiana scabra Bunge (Gentian), Gardenia jasminoides Ellis (Gardeniae fructus), Scutellaria baicalensis Georgi (Huangcen), Bupleurum chinense DC (Bupleurum), and Glycyrrhiza uralensis Fisch (Licorice) were identified as the core components.The core targets included SRC, MAPK3, MAPK1, PIK3R1, RELA and STAT3. GO functional enrichment and KEGG pathway enrichment analyses indicated that LDXG primarily modulated protein kinase activity, ATP binding, protein serine/threonine kinase activity and protein kinase binding.These processes involved the PI3K-Akt, HIF-1, VEGF, ErbB and FoXO. Animal experiments demonstrated LDXG can significantly lowered blood pressure level in chronic stress-induced hypertension rats,reduced the contents of src and STAT3 in the PVN and MAPK1 in the adrenal gland and reduced serum levels of angiotensin II (Ang II), cortisol and adrenocorticotropic hormone(ACTH). LDXG can attenuate chronic stress hypertension by regulating JAK/STAT, Src/MAPK and other signaling pathways and reducing the expression of Ang II through a variety of active compounds. - Source: PubMed
Publication date: 2026/04/17
Jia HuizhuoLv MingyaoYang YingWang ZheZhang YanzhaoZhou JinxuXia LongfeiZhang JingWan HaifuLi Na - Coxsackievirus infection can cause various diseases such as myocarditis and encephalitis, posing a serious threat to human health. However, there are currently no specific therapeutic drugs or effective vaccines for Coxsackievirus infection, so exploring new anti-Coxsackievirus agents is of great significance. Geniposide, an iridoid glycoside component from traditional Chinese medicine Gardenia jasminoides, has shown multiple pharmacological activities, but its antiviral effect against Coxsackievirus and related mechanisms remain unclear. - Source: PubMed
Publication date: 2026/04/02
Xia JianboShi ZuliangShen Mengxin - Pathological cardiac hypertrophy remains a major contributor to heart failure, with impaired glucose metabolism playing a central role. Although exercise is known to enhance myocardial glucose utilization, the long-term metabolic reprogramming effects of exercise and their role in preventing pathological hypertrophy are poorly understood. This study elucidates the mechanisms underlying the sustained metabolic memory induced by exercise-induced hypertrophic preconditioning (EHP) and its cardioprotective effects, with a focus on RNA methylation and arachidonic acid metabolism. - Source: PubMed
Publication date: 2026/04/20
Zheng CankunHuang XiaoxiaWei XinnanLiang ChangzhuChen LuLi MingjueZhang RuiHe MingyuanLi ZhihongLin RongzhanShen MengjiaLiu JichenWang QianchengHuang JianhuaLiao WangjunBin JianpingLin HairuoLiao Yulin - Zhideke granules (ZDKG) are a widely used Traditional Chinese Medicine Formula (TCMF) in clinical practice for treating various diseases caused by wind-heat invading the lung. However, identifying quality markers (Q-markers) and elucidating their compatible regularity are challenging due to the complex composition of ZDKG, which involves multiple active ingredients acting on diverse targets. This study aimed to understand the compatible regularity of ZDKG and identify quality markers among its volatile components. - Source: PubMed
Publication date: 2026/04/14
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