Ask about this productRelated genes to: MAP2K4 antibody
- Gene:
- MAP2K4 NIH gene
- Name:
- mitogen-activated protein kinase kinase 4
- Previous symbol:
- SERK1
- Synonyms:
- MEK4, JNKK1, PRKMK4, MKK4
- Chromosome:
- 17p12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-11
- Date modifiied:
- 2015-02-03
Related products to: MAP2K4 antibody
Related articles to: MAP2K4 antibody
- Colorectal adenoma (CRA) is a precancerous lesion that can progress to colorectal carcinoma (CRC); however, its malignant potential varies considerably. The present study aimed to characterize the putatively pathogenic variants (PPVs) of CRA and to assess their potential clinical relevance in identifying lesions with an increased risk of progression at precancerous stages. PPVs in a panel of 176 cancer-associated genes were analyzed in 67 CRA samples and matched adjacent normal mucosa using next-generation sequencing. The panel included genes involved in DNA repair pathways, cell cycle regulation and the genes directly associated with CRC development. PPVs in CRA tissue were identified in 44 patients. The most frequently mutated genes were found to be and , with mutations being the most prevalent. A higher frequency of PPVs was observed in CRA with high-grade dysplasia and tubulo-villous features. Notably, among the entire sample set, there were 10 hyperplastic polyps, which are generally considered low risk; however, three carried PPVs, specifically one polyp carried and mutations, another polyp carried and mutation, and a third carried a mutation. These findings suggested that mutational profiling may provide additional molecular information beyond histopathological assessment and could support improved risk stratification of colorectal lesions in early, precancerous stages. Such molecular characterization may be of value for identifying subsets of patients who could benefit from closer clinical surveillance. - Source: PubMed
Publication date: 2026/05/04
Valickova AnnaUrbanova MarketaHorak JosefJungwirth JiriKral JanHucl TomasMakajevova VeronikaSummerova SandraKohout PavelMatej RadoslavVodicka PavelVymetalkova Veronika - MicroRNA-7 (miR-7) suppresses pituitary gonadotropins, while icariin, an active compound from Epimedium brevicornu Maxim., exhibits estrogen-like properties. However, whether icariin regulates gonadotropins via miR-7 remains unclear. - Source: PubMed
Publication date: 2026/04/28
He JingChen AimingCai BingyanHuang KaiJi Zengjun - High-grade serous ovarian carcinoma (HGSC) is the sixth leading cause of cancer-related death among women. Most tumors arise from the Fallopian tubal epithelium (TE), exhibit numerous mutations, and present heterogenous pathological features. However, the contribution of specific mutation combinations to cellular transformation, pathological phenotype and chemotherapeutic responses remains unclear. We used a mouse TE organoid platform for combinatorial CRISPR mutagenesis of 20 candidate HGSC driver genes. Besides Trp53, mutations in Nf1, Cdkn2a and Map2k4 were the most prevalent in phenotypically transformed organoids. Map2k4 mutant organoids transplanted into mice predominantly yielded papillary-glandular carcinomas, whereas those with Nf1 mutations were more mesenchymal-like. Map2k4 mutant cells were particularly sensitive to paclitaxel, and Rho kinase inhibitor (ROCKi) increased trametinib sensitivity in both Map2k4- and Nf1-mutant organoids. This organoid mutagenesis strategy is powerful for unraveling the genetic and phenotypic complexity of HGSC, and identified Map2k4 as a potential therapeutic target in select HGSC cases. - Source: PubMed
Publication date: 2026/04/15
Phuong Daryl JRalston Coulter QEzzat Tony MAshe Christopher SArmstrong Amanda PFlesken-Nikitin AndreaYamulla Robert JNikitin Alexander YuSchimenti John C - Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) that contribute to tumor progression and therapeutic resistance in non-small cell lung cancer (NSCLC). However, effective strategies targeting CAF regulation remain limited. Here, we investigated the effects of the plant-derived compound 20(S)-Ginsenoside Rg3 on CAFs using an integrated network pharmacology and experimental validation approach. Network pharmacology analysis identified 107 overlapping targets between Rg3 and NSCLC. PPI network analysis highlighted EGFR, JUN, TP53, and STAT3 as key hub genes. KEGG enrichment analysis indicated that these targets were significantly enriched in the IL-17 and MAPK signaling pathways. These genes and pathways have been associated with fibroblast activation and tumor stromal remodeling, suggesting a potential role of Rg3 in regulating CAF-related processes within the tumor microenvironment. Functional experiments demonstrated that Rg3 inhibited CAF proliferation, colony formation and migration, while inducing apoptosis and mitochondrial dysfunction. Mechanistically, Rg3 upregulated IL-17RD and suppressed FGFR1-MAP2K4-JNK-c-Jun signaling. Furthermore, co-culture experiments revealed that Rg3-treated CAFs exhibited reduced pro-tumorigenic effects on NSCLC cells, indicating impaired tumor-stroma communication. Collectively, these findings demonstrate that 20(S)-Ginsenoside Rg3 suppresses CAF activation and function associated with the IL-17RD-FGF-MAP2K4-JNK-c-Jun signaling pathway, highlighting its potential as a tumor microenvironment-targeted therapeutic agent in NSCLC. - Source: PubMed
Publication date: 2026/04/06
Zhang XinyuXia LeiCheng FengZhuang JihongRao RuiyingMeng JiaqiXu JinheZhang WentingYu Zongyang - To evaluate targeted therapy for Langerhans cell histiocytosis (LCH) with maxillofacial manifestations, we conducted a retrospective study of 20 children admitted from January 2016 to June 2021. - Source: PubMed
Publication date: 2026/03/26
Jiang YangLi ZhigangYang YingZhang RuiWang TianyouYu Guoxia