Ask about this productRelated genes to: FOXA1 antibody
- Gene:
- FOXA1 NIH gene
- Name:
- forkhead box A1
- Previous symbol:
- HNF3A
- Synonyms:
- -
- Chromosome:
- 14q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-11
- Date modifiied:
- 2015-02-02
Related products to: FOXA1 antibody
Related articles to: FOXA1 antibody
- The greatest cause of death from breast cancer is metastasis, yet little is known about the molecular mechanisms behind this phenomenon. Using four publically accessible datasets, we conducted a thorough transcriptome analysis of 187 samples from seven breast cancer metastatic sites: the brain, bone, lung, liver, lymph nodes, skin, and local-regional skin (skinlr). Of the 12,005 genes that were found to be shared by all samples in this investigation, 604-885 differentially expressed genes (DEGs) were unique to each metastatic location. Pathways including PI3K-Akt signaling, prolactin signaling, complement, and coagulation cascades were identified by functional enrichment analysis as important metastasis drivers with unique functions in different locales. The results of regulatory analysis revealed 77 upstream factors, including 14 kinases (like EPHB3, PAK3) and 63 transcription factors (like ESR1, FOXA1, and GATA3), some of which were discovered for the first time in breast cancer metastases (like TCF4, HOXA10). It was shown that hub genes including MMP9, SPP1, and PDGFRB are essential for the survival and development of metastases, offering new information on site-specific biology. Crucially, by identifying site-specific molecular markers, these discoveries pave the way for personalized medicine techniques and allow tumor-specific therapy tactics, such as targeting Central Carbon Metabolism in lung and skin metastases. This work provides actionable options for tumor-specific treatment and tailored interventions by highlighting new molecular candidates and signaling pathways for metastatic breast cancer. - Source: PubMed
Publication date: 2026/05/12
Salari AliMikaeili Namini ArshamAlipour AramFarahani FatemehSalehi FarnazShafiei Tehrani Zahra SadatBagherpour GhasemYosefy FatemehJafari DelaramShahbazi AliMirzaei Chegeni MasoumehKhodadad Hossyni Mohammad AminSafari Kharkheshi MahboubehBakhshi Manjili Monire - Cellular plasticity is a hallmark of cancer, enabling tumor cells to alter identity and evade therapeutic pressure. In invasive mucinous adenocarcinoma of the lung (IMA), NK2 homeobox 1 (NKX2-1) loss triggers a pulmonary to gastric switch marked by aberrant activation of hepatocyte nuclear factor 4 alpha (HNF4α), a master regulator of gastrointestinal/hepatic differentiation. We show that HNF4α promotes IMA growth and activates a gastric pit cell-like program. Loss of HNF4α enables forkhead box A1/A2 (FoxA1/2) transcription factors to bind de novo sites and activate alternative, non-gastric identities in IMA. HNF4α also establishes a mucinous program associated with tolerance to KRAS blockade, and loss of HNF4α enhances response to KRASG12D inhibition. Mechanistically, HNF4α blocks cell cycle exit in drug-tolerant persister cells and promotes activity of the antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NRF2). NRF2 activation partially rescues effects of Hnf4a deletion on KRASG12D inhibition, whereas NRF2 inhibition enhances sensitivity to KRASG12D blockade. Thus, HNF4α is a key regulator of growth, identity, and primary response to KRASG12D inhibition in IMA. - Source: PubMed
Publication date: 2026/05/12
Essel Dadzie HeadtloveGreen Yangsook SongCamolotto SoledadArnold Henry UGumbleton MatthewGuo MinzheMino-Kenudson MariMaeda YutakaSpike Benjamin TSnyder Eric L - This study investigates the impact of daily intake of (poly)phenol-rich foods (PP-rich foods) on gene expression in postmenopausal women. Due to the fall in estrogen during menopause, women experience significant physiological and metabolic changes, increasing the risk of chronic diseases. Previous studies suggest that (poly)phenols may help mitigate these changes by modulating gene expression. However, the effect of consuming various (poly)phenol classes simultaneously had not been well explored. In this study, blood samples were collected before and after daily PP-rich foods consumption for 2 months (dark chocolate, green tea, and mix-fruit juice: pomegranate, berries and orange) by postmenopausal women to evaluate the nutrigenomic effect. Global gene expression was analyzed, and bioinformatics tools were used to assess differentially expressed genes (DEGs) and their functional roles. The results revealed significant changes in gene expression, including protein-coding genes (mRNA) as well as non-coding RNA types like microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs). These DEGs were involved in regulating key processes such as endocrine function, inflammation, metabolism, cell signaling, and adhesion. In silico docking analyses suggested that gut microbiota metabolites (valerolactones and urolithins) and phase II-derived metabolites (glucuronides of cocoa flavan-3ols and orange flavanones), presented higher potential binding capacity for FOXA1, PURA, RUNX3 and RXRA than the low molecular weight phenolic acid catabolites. Gene expression profiles after PP-rich foods consumption were also inversely correlated with the expression profiles of patients with cardiometabolic disorders. These findings suggest that the PP-rich foods selected may improve cardiometabolic health by modulating gene expression, resulting in a promising dietary approach to reduce adverse effects during menopause. - Source: PubMed
Publication date: 2026/04/16
Sánchez-Martínez LorenaMilenkovic DraganPeriago Mª JesúsGonzález-Barrio Rocío - - Source: PubMed
Publication date: 2026/05/11
Qiu MeitingBao WeiWang JingyunYang TingtingHe XiaoyingLiao YunWan Xiaoping - Prostate cancer is one of the most common malignancies in men and a major cause of cancer-related mortality worldwide. While second-generation antiandrogens induce durable responses, they have also led to the emergence of aggressive, androgen-independent subtypes of prostate cancer, including small cell carcinoma of the prostate. The diagnosis of these subtypes remains challenging due to the frequent loss of traditional prostatic markers, and novel prostate-specific markers are needed in routine pathology practice. - Source: PubMed
Publication date: 2026/05/07
Zhao JianpingYao JunHosseini HosseinBaraban EzraLin RuiheGuo Charles CHuo LeiLu WeiKhan KhajaWang ShufangSoto Luisa Maren SolisDing Qingqing